Auflistung Nach Schlagwort "inhibition constant"

Anzeige der Dokumente 1-2 von 2

Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors

Chetter B.A., Kyriakis E., Barr D., Karra A.G., Katsidou E., Koulas S.M., Skamnaki V.T., Snape T.J., Psarra A.-M.G., Leonidas D.D., Hayes J.M. (2020)

Glycogen phosphorylase (GP) is an important target for the development of new anti-hyperglycaemic agents. Flavonoids are novel inhibitors of GP, but their mode of action is unspecific in terms of the GP binding sites ...
Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-D-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase

Kantsadi A.L., Bokor É., Kun S., Stravodimos G.A., Chatzileontiadou D.S.M., Leonidas D.D., Juhász-Tóth É., Szakács A., Batta G., Docsa T., Gergely P., Somsák L. (2016)

C-β-D-Glucopyranosyl pyrrole derivatives were prepared in the reactions of pyrrole, 2-, and 3-aryl-pyrroles with O-peracetylated β-D-glucopyranosyl trichloroacetimidate, while 2-(β-D-glucopyranosyl) indole was obtained by ...