Browsing by Subject "gamma interferon"

An Activating Janus kinase-3 mutation is associated with cytotoxic T lymphocyte antigen-4-dependent Immune dysregulation syndrome

Sic H., Speletas M., Cornacchione V., Seidl M., Beibel M., Linghu B., Yang F., Sevdali E., Germenis A.E., Oakeley E.J., Vangrevelinghe E., Sailer A.W., Traggiai E., Gram H., Eibel H. (2017)

Heterozygous mutations in the cytotoxic T lymphocyte antigen-4 (CTLA-4) are associated with lymphadenopathy, autoimmunity, immune dysregulation, and hypogammaglobulinemia in about 70% of the carriers. So far, the incomplete ...

Anti-cd20 agents for multiple sclerosis: Spotlight on ocrelizumab and ofatumumab

Florou D., Katsara M., Feehan J., Dardiotis E., Apostolopoulos V. (2020)

Until recently, in the pathogenesis of Multiple Sclerosis (MS), the contribution of B cells has been largely underestimated, and the disease was considered a T-cell-mediated disorder. However, newer evidence shows that B ...

Apremilast increases IL-10-producing regulatory B cells and decreases proinflammatory T cells and innate cells in psoriatic arthritis and psoriasis

Mavropoulos A., Zafiriou E., Simopoulou T., Brotis A.G., Liaskos C., Roussaki-Schulze A., Katsiari C.G., Bogdanos D.P., Sakkas L.I. (2019)

Objectives: Psoriatic arthritis (PsA) and psoriasis are immune-mediated inflammatory diseases sharing common immunological mechanisms. Regulatory B cells (Breg cells) producing IL-10 (B10 cells), a critical anti-inflammatory ...

Association of melatonin administration in pregnant ewes with growth, redox status and immunity of their offspring

Bouroutzika E., Ciliberti M.G., Caroprese M., Theodosiadou E., Papadopoulos S., Makri S., Skaperda Z.-V., Kotsadam G., Michailidis M.-L., Valiakos G., Chadio S., Kouretas D., Valasi I. (2021)

In this study, the effects of melatonin treatment on growth, redox status and immunity in prenatally stressed newborn lambs were evaluated. Thirty-seven newborn lambs were allocated into two groups (melatonin-MEL and ...

Blocking of interleukin-10 receptor - A novel approach to stimulate T-helper cell type 1 responses to hepatitis C virus

Rigopoulou, E. I.; Abbott, W. G. H.; Haigh, P.; Naoumov, N. V. (2005)

Chronic hepatitis C virus (HCV) infection is associated with weak CD4+ T-helper type 1 reactivity and enhanced interleukin-10 production to HCV antigens. Here we demonstrate in vitro that monoclonal antibody-induced blockade ...

CD8+ PD-1+ T-cells and PD-L1+ circulating tumor cells in chemotherapy-naïve non-small cell lung cancer: towards their clinical relevance?

Kotsakis A., Kallergi G., Aggouraki D., Lyristi Z., Koinis F., Lagoudaki E., Koutsopoulos A., Georgoulias V., Vetsika E.-K. (2019)

Background: Since tumor cells may escape from immune surveillance through the programmed cell death 1 (PD-1)/programmed death ligand (PD-L)1 axis, this study was designed in order to evaluate whether there is a correlation ...

Could IFN-γ predict the development of residual pleural thickening in tuberculous pleurisy?

Gerogianni, I.; Papala, M.; Tsopa, P.; Zigoulis, P.; Dimoulis, A.; Kostikas, K.; Kiropoulos, T.; Gourgoulianis, K. I. (2008)

Could IFN-γ predict the development of residual pleural thickening tuberculous pleurisy? I. Gerogianni, M. Papala, P. Tsopa, P. Zigoulis, A. Dimoulis, K. Kostikas, T. Kiropoulos, KI Gourgoulianis. Background. The aim of ...

COVID-19 immunopathology and the central nervous system: Implication for multiple sclerosis and other autoimmune diseases with associated demyelination

Boziki M.K., Mentis A.-F.A., Shumilina M., Makshakov G., Evdoshenko E., Grigoriadis N. (2020)

In the frame of the coronavirus disease 2019 (COVID-19) pandemic, recent reports on SARS-CoV-2 potential neuroinvasion placed neurologists on increased alertness in order to assess early neurological manifestations and ...

Curcumin mediates attenuation of pro-inflammatory interferon γ and interleukin 17 cytokine responses in psoriatic disease, strengthening its role as a dietary immunosuppressant

Skyvalidas D.Ν., Mavropoulos A., Tsiogkas S., Dardiotis E., Liaskos C., Mamuris Z., Roussaki-Schulze A., Sakkas L.I., Zafiriou E., Bogdanos D.P. (2020)

Curcumin exhibits anti-inflammatory properties and has been used for centuries in traditional medicine and as dietary supplement. Data from clinical trials has strengthened the notion that curcumin may exert an anti-inflammatory ...

Current and future aspects of TIM-3 as biomarker or as potential targeted in non-small cell lung cancer scope: Is there a role in clinical practice?

de Mello R.A., Zhu J.-H., Iavelberg J., Potim A.H., Simonetti D., Júnior J.A.S., Castelo-Branco P., Pozza D.H., Tajima C.C., Tolia M., Antoniou G. (2020)

[No abstract available]

Delphinidin diminishes in vitro interferon-γ and interleukin-17 producing cells in patients with psoriatic disease

Tsiogkas S.G., Mavropoulos Α., Skyvalidas D.N., Patrikiou E., Ntavari N., Daponte A.I., Grammatikopoulou M.G., Dardiotis E., Roussaki-Schulze A.-V., Sakkas L.I., Zafiriou E., Bogdanos D.P. (2022)

The anthocyanidin delphinidin reduces psoriasiform lesions and inflammatory mediators in human cell culture systems. Its role in psoriatic disease has not yet been investigated. We assessed delphinidin’s in vitro ...

Differential effects of the two amino acid sensing systems, the GCN2 kinase and the mTOR complex 1, on primary human alloreactive CD4+ T-cells

Eleftheriadis T., Pissas G., Antoniadi G., Liakopoulos V., Tsogka K., Sounidaki M., Stefanidis I. (2016)

Amino acid deprivation activates general control nonderepressible 2 (GCN2) kinase and inhibits mammalian target of rapamycin (mTOR), affecting the immune response. In this study, the effects of GCN2 kinase activation or ...

Discrimination of exudative pleural effusions based on multiple biological parameters

Daniil, Z. D.; Zintzaras, E.; Kiropoulos, T.; Papaioannou, A. I.; Koutsokera, A.; Kastanis, A.; Gourgoulianis, K. I. (2007)

Pleural effusion is a common complication of various diseases. Conventional methods are not always capable of establishing the cause of pleural effusion, so alternative tests are needed. The aim of this study was to explore ...

Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions

Dardiotis E., Siokas V., Garas A., Paraskevaidis E., Kyrgiou M., Xiromerisiou G., Deligeoroglou E., Galazios G., Kontomanolis E.N., Spandidos D.A., Tsatsakis A., Daponte A. (2018)

Human papillomavirus (HPV) infection alone is not sufficient to explain the development of cervical cancer. Genetic variants have been linked to the development of precancerous lesions and cervical cancer. In this study, ...

Hepatitis D virus-specific cytokine responses in patients with chronic hepatitis delta before and during interferon alfa-treatment

Grabowski, J.; Yurdaydìn, C.; Zachou, K.; Buggisch, P.; Hofmann, W. P.; Jaroszewicz, J.; Schlaphoff, V.; Manns, M. P.; Cornberg, M.; Wedemeyer, H. (2011)

Background: Hepatitis delta is caused by infection with the hepatitis D virus (HDV) and is considered the most severe form of viral hepatitis. Treatment options for hepatitis delta are limited, with only 25% of patients ...

IFNs-signaling effects on lung cancer: an up-to-date pathways-specific review

Galani V., Kastamoulas M., Varouktsi A., Lampri E., Mitselou A., Arvanitis D.L. (2017)

IFNs have found important applications in clinical medicine, including the treatment of lung malignancies. The biological effect of the IFN-receptor signaling is regulated essentially by three factors: the expression profile ...

IL-10 producing Bregs are impaired in psoriatic arthritis and psoriasis and inversely correlate with IL-17- and IFNγ-producing T cells

Mavropoulos A., Varna A., Zafiriou E., Liaskos C., Alexiou I., Roussaki-Schulze A., Vlychou M., Katsiari C., Bogdanos D.P., Sakkas L.I. (2017)

Our aim was to study CD19(+)CD27(+)CD24(high) memory and CD19(+)CD24(high)CD38(high) transitional and IL-10 + Breg cells, known to inhibit Th1 and Th17 cells in experimental arthritis, in psoriatic arthritis (PsA) and ...

IL-10-producing regulatory B cells (B10 cells), IL-17 + T cells and autoantibodies in systemic sclerosis

Mavropoulos A., Liaskos C., Simopoulou T., Bogdanos D.P., Sakkas L.I. (2017)

We aimed to analyze IL-10 + Breg (B10) cells, found to be reduced in systemic sclerosis (SSc), in relation to SSc-specific autoAbs and IL-17 + and IFNγ + T cells in SSc. Peripheral blood B10 cells from 26 patients with SSc ...

In Mixed Lymphocyte Reaction, the Hypoxia-Inducible Factor Prolyl-Hydroxylase Inhibitor Roxadustat Suppresses Cellular and Humoral Alloimmunity

Eleftheriadis T., Pissas G., Mavropoulos A., Nikolaou E., Filippidis G., Liakopoulos V., Stefanidis I. (2020)

Hypoxia-inducible factor (HIF) prolyl-hydroxylase inhibitors are currently used for the treatment of renal anemia. Since HIF affects immune cells, we evaluated the effect of such a drug, the roxadustat, on adaptive immunity. ...

Interactome of obesity: Obesidome: Genetic obesity, stress induced obesity, pathogenic obesity interaction

Geronikolou S.A., Pavlopoulou A., Cokkinos D., Chrousos G. (2017)

Obesity is a chronic disease of increasing prevalence reaching epidemic proportions. Genetic defects as well as epigenetic effects contribute to the obesity phenotype. Investigating gene (e.g. MC4R defects)-environment ...