Listar por tema "cell aging"

Age-specific and lifetime behavior patterns in Drosophila melanogaster and the Mediterranean fruit fly, Ceratitis capitata

Carey, J. R.; Papadopoulos, N.; Kouloussis, N.; Katsoyannos, B.; Müller, H. G.; Wang, J. L.; Tseng, Y. K. (2006)

Patterns of behavior were recorded every 10 min during a 2-h period each day from eclosion to death for individual Drosophila melanogaster (both sexes) and Ceratitis capitata (males-only) including walking, preening, ...

Dapagliflozin Prevents High-Glucose-Induced Cellular Senescence in Renal Tubular Epithelial Cells

Eleftheriadis T., Pissas G., Filippidis G., Efthymiadi M., Liakopoulos V., Stefanidis I. (2022)

Gliflozins are a new class of antidiabetic drugs with renoprotective properties. In cultures of primary human renal tubular epithelial cells (RPTECs) subjected to high-glucose conditions in the presence or absence of ...

Dysregulation of caveolin-1 phosphorylation and nuclear translocation is associated with senescence onset

Goutas A., Outskouni Z., Papathanasiou I., Satra M., Koliakos G., Trachana V. (2021)

We recently reported that the inability of osteoarthritic (OA) chondrocytes to repair oxidative stress (OS) induced DNA damage is linked to Cav-1 overexpression/improper localization. We speculated that the senescent status ...

Fasting-mediated metabolic and toxicity reprogramming impacts circulating microRNA levels in humans

Ravanidis S., Grundler F., de Toledo F.W., Dimitriou E., Tekos F., Skaperda Z., Kouretas D., Doxakis E. (2021)

It is well-established that long-term fasting improves metabolic health, enhances the total antioxidant capacity and increases well-being. MicroRNAs oversee energy homeostasis and metabolic processes and are widely used ...

Human mesenchymal stem cells with enhanced telomerase activity acquire resistance against oxidative stress-induced genomic damage

Trachana V., Petrakis S., Fotiadis Z., Siska E.K., Balis V., Gonos E.S., Kaloyianni M., Koliakos G. (2017)

Background Human mesenchymal stem cells (MSC) are important tools for several cell-based therapies. However, their use in such therapies requires in vitro expansion during which MSCs quickly reach replicative senescence. ...

Pathogenesis of chronic heart failure: cardiovascular aging, risk factors, comorbidities, and disease modifiers

Triposkiadis F., Xanthopoulos A., Parissis J., Butler J., Farmakis D. (2022)

Chronic heart failure (HF) is rare in the young and common in the elderly in the Western world. HF in the young is usually due to specific causes, predominantly or exclusively affecting the heart (adult congenital heart ...

Reporting on the Role of miRNAs and Affected Pathways on the Molecular Backbone of Ovarian Insufficiency: A Systematic Review and Critical Analysis Mapping of Future Research

Rapani A., Nikiforaki D., Karagkouni D., Sfakianoudis K., Tsioulou P., Grigoriadis S., Maziotis E., Pantou A., Voutsina A., Pantou A., Koutsilieris M., Hatzigeorgiou A., Pantos K., Simopoulou M. (2021)

Ovarian insufficiency is identified as a perplexing entity in the long list of pathologies impairing fertility dynamics. The three distinct classifications of ovarian insufficiency are poor ovarian response, premature ...

The role of indoleamine 2,3-dioxygenase in renal tubular epithelial cells senescence under anoxia or reoxygenation

Eleftheriadis T., Pissas G., Filippidis G., Liakopoulos V., Stefanidis I. (2021)

Ischemia-reperfusion injury is the commonest form of acute kidney injury (AKI). Tubular epithelial cell senescence contributes to incomplete recovery from AKI and predisposes to subsequent chronic kidney disease. In cultures ...

Understanding the role of chondrocytes in osteoarthritis: utilizing proteomics

Trachana V., Mourmoura E., Papathanasiou I., Tsezou A. (2019)

Introduction: Proteomic analyses have been acknowledged to carry a significant prospective in elucidating the pathogenesis of several diseases, including osteoarthritis (OA). But it has not been an easy road: major technical ...