Browsing by Subject "cancer radiotherapy"

Accelerated hypofractionated radiotherapy schedules in breast cancer: A review of the current literature

Kalogeridi, M. A.; Kelekis, N.; Kouvaris, J.; Platoni, K.; Kyrias, G.; Pectasides, D.; Kouloulias, V. (2009)

Lumpectomy followed by breast irradiation is an alternative to mastectomy for patients with early-stage breast cancer. The purpose of radiation treatment following lumpectomy is to minimize the risk of recurrent cancer in ...

Addressing the post-irradiation hypothalamic-pituitary endocrine abnormalities of brain tumors in pediatric patients

Velentza L., Tolia M., Christakou C., Nikolaou M., Zerdes I.-N., Tsoukalas N., Hajiioannou J., Tsanadis K., Rigas G., Mitsis M., Theodorou K., Pistevou-Gombaki K., Tsekeris P., Kyrgias G. (2017)

Purpose: Hypothalamic-pituitary axis is susceptible to radiotherapy, causing endocrine disorders to childhood cancer survivors. We conducted a systematic review in order to assess the radiation-induced toxicity that leads ...

Benign intracranial lesions-radiotherapy: An overview of treatment options, indications and therapeutic results

Tzikoulis V., Gkantaifi A., Alongi F., Tsoukalas N., Saraireh H.H., Charalampakis N., Tzikoulis G., Andreou E., Tsapakidis K., Kardamakis D., Tsanadis K., Kyrgias G., Tolia M. (2020)

Background: Radiation Therapy (RT) is an established treatment option for benign intracranial lesions. The aim of this study is to display an update on the role of RT concerning the most frequent benign brain lesions and ...

Breast radiotherapy and early adverse cardiac effects. The role of serum biomarkers and strain echocardiography

Gkantaifi A., Papadopoulos C., Spyropoulou D., Toumpourleka M., Iliadis G., Kardamakis D., Nikolaou M., Tsoukalas N., Kyrgias G., Tolia M. (2019)

Breast cancer radiotherapy has a clear benefit for both long-term survival and local recurrence rate. However, there is still much concern about the early radiation-induced heart toxicity. This article aimed to clarify the ...

Brentuximab vedotin in relapsed/refractory Hodgkin lymphoma. The Hellenic experience

Angelopoulou M.K., Vassilakopoulos T.P., Batsis I., Sakellari I., Gkirkas K., Pappa V., Giannoulia P., Apostolidis I., Apostolopoulos C., Roussou P., Panayiotidis P., Dimou M., Kyrtsonis M.-C., Palassopoulou M., Vassilopoulos G., Moschogiannis M., Kalpadakis C., Margaritis D., Spyridonidis A., Michalis E., Anargyrou K., Repousis P., Hatzimichael E., Bousiou Z., Poulakidas E., Grentzelias D., Harhalakis N., Pangalis G.A., Anagnostopoulos A., Tsirigotis P. (2018)

This retrospective study aimed to describe the Hellenic experience on the use of brentuximab vedotin (BV) in relapsed/refractory (R/R) Hodgkin lymphoma (HL) given within its indication. From June 2011 to April 2015, ...

Can bioelectrical impedance analysis and BMI be a prognostic tool in head and neck cancer patients? A review of the evidence

Mantzorou M., Tolia M., Poultsidi A., Pavlidou E., Papadopoulou S.K., Papandreou D., Giaginis C. (2020)

Background: Malnutrition can significantly affect disease progression and patient survival. The efficiency of weight loss and bioimpedance analysis (BIA)-derived measures in the evaluation of malnutrition, and disease ...

Cancer-associated stroke: Pathophysiology, detection and management (Review)

Dardiotis E., Aloizou A.-M., Markoula S., Siokas V., Tsarouhas K., Tzanakakis G., Libra M., Kyritsis A.P., Brotis A.G., Aschner M., Gozes I., Bogdanos D.P., Spandidos D.A., Mitsias P.D., Tsatsakis A. (2019)

Numerous types of cancer have been shown to be associated with either ischemic or hemorrhagic stroke. In this review, the epidemiology and pathophysiology of stroke in cancer patients is discussed, while providing vital ...

Clinical validation of the LKB model and parameter sets for predicting radiation-induced pneumonitis from breast cancer radiotherapy

Tsougos, I.; Mavroidis, P.; Theodorou, K.; Rajala, J.; Pitkänen, M. A.; Holli, K.; Ojala, A. T.; Hyödynmaa, S.; Järvenpää, R.; Lind, B. K.; Kappas, C. (2006)

The choice of the appropriate model and parameter set in determining the relation between the incidence of radiation pneumonitis and dose distribution in the lung is of great importance, especially in the case of breast ...

Clinical value of significance of hypoxia inducible factor-1α, glucose transporter-1 and carbonic anhydrase IX in rectal cancer after preoperative chemoradiotherapy

Vitoratou D.-I., Tolia M., Liakos P., Tsoukalas N., Giaginis C., Nikolaou M., Nikolaou G., Rigas G., Psarianos K., Lioupis A., Kyrgias G. (2019)

Purpose: The standard treatment of rectal cancer is surgery along with preoperative radiotherapy, administered alone or in combination with chemotherapy. Preoperative chemoradiotherapy (preCRT) is widely used as it allows ...

Competing mortality in patients with neuroendocrine tumors

Low S.K., Giannis D., Bahaie N.S., Trong B.L.H., Moris D., Huy N.T. (2019)

Objectives: Patients with neuroendocrine tumors (NETs) are at increased risk of mortality from competing causes in light of the improvement in overall survival over recent decades. The purpose of this study was to explore ...

Current and future aspects of TIM-3 as biomarker or as potential targeted in non-small cell lung cancer scope: Is there a role in clinical practice?

de Mello R.A., Zhu J.-H., Iavelberg J., Potim A.H., Simonetti D., Júnior J.A.S., Castelo-Branco P., Pozza D.H., Tajima C.C., Tolia M., Antoniou G. (2020)

[No abstract available]

The current role of surgery in the treatment of cardiac metastases from malignant melanoma: An educational presentation

Spiliopoulos K., Engels P., Kimpouri K., Floudas I., Salemis N.S., Schmid F.-X. (2021)

A 71 year-old male with a history of multiple excisions of an initial Clark’s level V melanoma of the breast followed by combined radiation and interferon treatment, as well as a recurrence, 3 years later, of a BRAF-positive ...

Depression in choroidal melanoma patients treated with proton beam radiotherapy

Moschos M.M., Moustafa G.A., Lavaris A., Damaskos C., Laios K., Karathanou E., Ladas D.S., Asproudis I., Garmpis N., Kalogeropoulos C. (2018)

Aim: To determine depression in patients with choroidal melanoma (CM) treated with proton beam radiotherapy. Patients and Methods: This was a cross-sectional study including 50 patients with CM (50% males, mean age=49.88±6.34 ...

Dosimetric and radiobiological evaluation of four radiation techniques in preoperative rectal cancer radiotherapy

Softa V., Kiouvrekis Y., Makridou A., Kappas C., Kyrgias G., Theodorou K. (2021)

Purpose: To compare tumour dose distribution, conformality, homogeneity, normal tissue avoidance, tumour control probability (TCP) and normal tissue complication probability (NTCP) using 3D conformal radiation therapy ...

Emerging molecular networks common in ionizing radiation, immune and inflammatory responses by employing bioinformatics approaches

Georgakilas, A. G.; Pavlopoulou, A.; Louka, M.; Nikitaki, Z.; Vorgias, C. E.; Bagos, P. G.; Michalopoulos, I. (2015)

Efficient radiation therapy is characterized by enhanced tumor cell killing involving the activation of the immune system (tumor immunogenicity) but at the same time minimizing chronic inflammation and radiation adverse ...

The epidemiology, staging and outcomes of sarcomatoid hepatocellular carcinoma: A SEER population analysis

Giannis D., Morsy S., Geropoulos G., Esagian S.M., Sioutas G.S., Moris D. (2021)

Background: Hepatocellular carcinoma (HCC) subtypes differ in terms of histopathology and prognosis. Sarcomatoid HCC is rare and literature concerning the survival of patients with sarcomatoid HCC is scarce. Materials and ...

Ewing's sarcoma of the clavicle: A case report

Igoumenou V.G., Economopoulou P., Agrogiannis G., Dailiana Z., Mavrogenis A.F. (2018)

There is a paucity of literature on the management of patients with Ewing's sarcoma of the clavicle, with few existing published papers. To enhance the literature, this article presents an adolescent with Ewing's sarcoma ...

An exploratory study of radiation dermatitis in breast cancer patients

Alexopoulou E., Katsila T., Tolia M., Tsoukalas N., Leontsinidis M., Kyrgias G., Kouloulias V., Patrinos G.P., Spyropoulou D., Kardamakis D. (2018)

Background/Aim: Radiation dermatitis is observed in 95% of breast cancer patients receiving radiotherapy. The aim of this study was to explore the correlation between protein expression in tumor cells and the risk of ...

The fate of BRCA1-related germline mutations in triple-negative breast tumors

Kotoula V., Fostira F., Papadopoulou K., Apostolou P., Tsolaki E., Lazaridis G., Manoussou K., Zagouri F., Pectasides D., Vlachos I., Tikas I., Lakis S., Konstantopoulou I., Pentheroudakis G., Gogas H., Papakostas P., Christodoulou C., Bafaloukos D., Razis E., Karavasilis V., Bamias C., Yannoukakos D., Fountzilas G. (2017)

The preservation of pathogenic BRCA1/2 germline mutations in tumor tissues is usually not questioned, while it remains unknown whether these interact with somatic genotypes for patient outcome. Herein we compared germline ...

Focus on the use of resveratrol as an adjuvant in glioblastoma therapy

Dionigi L., Ragonese F., Monarca L., Covino S., de Luca A., Iannitti R.G., Bastioli F., Moulas A.N., Allegretti M., Fioretti B. (2020)

Glioblastoma (GB) represents the most common and malignant form of glioma cancer. The Gold Standard in Glioblastoma is neurosurgical tumor removal and radiotherapy treatment in concomitant with temo-zolomide (TMZ). ...