Auflistung Nach Schlagwort "antidiabetic agent"

Adherence to oral anticoagulation in ischemic stroke patients with atrial fibrillation

Tiili P., Leventis I., Kinnunen J., Svedjebäck I., Lehto M., Karagkiozi E., Sagris D., Ntaios G., Putaala J. (2021)

Background: Non-vitamin K antagonist oral anticoagulants (NOAC) have superior safety and comparable efficacy profile compared to vitamin-K antagonists (VKAs), with more convenient dosing schemes. However, issues with ...

Affinity crystallography reveals the bioactive compounds of industrial juicing byproducts of Punica granatum for glycogen phosphorylase

Stravodimos G.A., Kantsadi A.L., Apostolou A., Kyriakis E., Kafaski-Kanelli V.-N., Solovou T., Gatzona P., Liggri P.G.V., Theofanous S., Gorgogietas V.A., Kissa A., Psachoula C., Lemonakis A., Chatzileontiadou D.S.M., Psarra A.-M.G., Skamnaki V.T., Haroutounian S.A., Leonidas D.E. (2018)

Background: Glycogen phosphorylase (GP) is a pharmaceutical target for the discovery of new antihyperglycaemic agents. Punica granatum is a well-known plant for its potent antioxidant and antimicrobial activities but so ...

Comparable or higher prevalence of comorbidities in antiphospholipid syndrome vs rheumatoid arthritis: A multicenter, case-control study

Panopoulos S., Thomas K., Georgiopoulos G., Boumpas D., Katsiari C., Bertsias G., Drosos A.A., Boki K., Dimitroulas T., Garyfallos A., Papagoras C., Katsimbri P., Tziortziotis A., Adamichou C., Kaltsonoudis E., Argyriou E., Vosvotekas G., Sfikakis P.P., Vassilopoulos D., Tektonidou M.G. (2021)

Objectives: Evidence on comorbidity prevalence in antiphospholipid syndrome (APS) and its difference from high comorbidity burden rheumatic diseases is limited. Herein, we compare multiple comorbidities between APS and RA. ...

Comparison of Risk Scores for the Prediction of the Overall Cardiovascular Risk in Patients with Ischemic Stroke: The Athens Stroke Registry

Georgiopoulos G., Ntaios G., Stamatelopoulos K., Manios E., Korompoki E., Vemmou E., Milionis H., Masi S., Lip G.Y.H., Vemmos K. (2019)

Background: Stratification of overall vascular risk in patients with ischemic stroke is important as it may guide management decisions. Currently available schemes have only modest prognostic accuracy. The TRA2°P score ...

Cost Effectiveness of Exenatide Once Weekly Versus Insulin Glargine and Liraglutide for the Treatment of Type 2 Diabetes Mellitus in Greece

Tzanetakos C., Bargiota A., Kourlaba G., Gourzoulidis G., Maniadakis N. (2018)

Objective: The objective of this study was to evaluate the long-term cost effectiveness of exenatide once weekly (ExQW) versus insulin glargine (IG) or liraglutide 1.2 mg (Lira1.2mg) for the treatment of adult patients ...

Do the Kinetics of Antibody Responses Predict Clinical Outcome in Hospitalized Patients With Moderate-to-Severe COVID-19?

Pavlidis G., Kampolis C.F., Perlepe G., Pagonis A., Maniotis C., Koullias E., Kranidioti H., Kyritsis A., Pavlou E., Sinis S., Pirounaki M., Vassilopoulos D., Gourgoulianis K., Pantazopoulos I. (2022)

Background/Aim: The relationship between the kinetics of antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the severity of Coronavirus Disease 2019 (COVID-19) is poorly understood. The ...

Drug-induced endocrinopathies and diabetes: A combo-endocrinology overview

Diamanti-Kandarakis E., Duntas L., Kanakis G.A., Kandaraki E., Karavitaki N., Kassi E., Livadas S., Mastorakos G., Migdalis I., Miras A.D., Nader S., Papalou O., Poladian R., Popovic V., Rachoń D., Tigas S., Tsigos C., Tsilchorozidou T., Tzotzas T., Bargiota A., Pfeifer M., on behalf of COMBO ENDO TEAM: 2018 (2019)

In the currently overwhelming era of polypharmacy, the balance of the dynamic and delicate endocrine system can easily be disturbed by interfering pharmaceutical agents like medications. Drugs can cause endocrine abnormalities ...

Effect of fully automated closed-loop insulin delivery using faster aspart versus standard aspart on gluco-regulatory hormones in type 2 diabetes

Herzig D., Studer D., Nakas C.T., Kuenzli C., Stauffer T.P., Hovorka R., Bally L. (2021)

We retrospectively assessed gluco-regulatory hormones over 10 h (including two meals) of fully automated closed-loop insulin delivery using faster (FA) versus standard insulin aspart (IAsp) in adults with type 2 diabetes ...

The Effect of Metformin on the Endometrium of Women with Polycystic Ovary Syndrome

Dragamestianos C., Messini C.I., Antonakis P.T., Zacharouli K., Kostopoulou E., Makrigiannakis A., Georgoulias P., Anifandis G., Dafopoulos K., Garas A., Daponte A., Messinis I.E. (2019)

Objectives: To investigate the effect of metformin on endometrial receptivity in women with polycystic ovary syndrome (PCOS). Methods: Twenty volunteer women with polycystic ovaries and oligomenorrhea were prospectively ...

Evidence for Cardiorenal Protection with SGLT-2 Inhibitors and GLP-1 Receptor Agonists in Patients with Diabetic Kidney Disease

Georgianos P.I., Vaios V., Roumeliotis S., Leivaditis K., Eleftheriadis T., Liakopoulos V. (2022)

For almost two decades, the management of patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) was based on the optimal glycemic and blood pressure control as well as on the adequate blockade of ...

Glycogenic hepatopathy as a cause of severe deranged liver enzymes in a young patient with type 1 diabetes mellitus

Azariadis K., Gatselis N.K., Koukoulis G.K., Dalekos G.N. (2019)

Glycogenic hepatopathy (GH) is a rare complication of poorly controlled type 1 diabetes mellitus (T1DM). We present a 19-year-old woman with T1DM and autoimmune thyroiditis who admitted to our department because of abrupt ...

Insulin resistance intervention after stroke trial of pioglitazone: Is this perhaps the end of the beginning?

Ntaios G., Kent T.A. (2016)

[No abstract available]

Mechanisms for cardiorenal protection of sglt-2 inhibitors

Georgianos P.I., Vaios V., Dounousi E., Salmas M., Eleftheriadis T., Liakopoulos V. (2021)

Despite optimal treatment of diabetic kidney disease (DKD) with adequate blood pressure control and agents blocking the renin-angiotensin-system (RAS), the residual cardiorenal risk of these patients remains substantially ...

Meta-analysis Evaluating the Effect of Sodium-Glucose Co-Transporter-2 Inhibitors on the Risk for New-Onset Obstructive Sleep Apnea in Patients With Type 2 Diabetes Mellitus Regardless of Cardiovascular Disease at Baseline

Patoulias D., Dimosiari A., Michailidis T., Roditis P., Lampropoulos S. (2022)

[No abstract available]

Non-insulin agents for the management of gestational diabetes: lack of evidence versus lack of action

Koufakis T., Garas A., Zebekakis P., Kotsa K. (2021)

[No abstract available]

Perioperative Fully Closed-Loop Insulin Delivery in Patients Undergoing Elective Surgery: An Open-Label, Randomized Controlled Trial

Herzig D., Suhner S., Roos J., Schurch D., Cecchini L., Nakas C.T., Weiss S., Kadner A., Kocher G.J., Guensch D.P., Wilinska M.E., Raabe A., Siebenrock K.A., Beldi G., Gloor B., Hovorka R., Vogt A.P., Bally L. (2022)

OBJECTIVE Perioperative management of glucose levels remains challenging. We aimed to assess whether fully closed-loop subcutaneous insulin delivery would improve glycemic control compared with standard insulin therapy in ...

Pharmacokinetics of Faster and Standard Insulin Aspart during Fully Closed-Loop Insulin Delivery in Type 2 Diabetes

Herzig D., Dehais J., Prost J.-C., Nakas C.T., Stettler C., Bally L., Hovorka R. (2020)

Background: Faster insulin aspart is a novel formulation of insulin aspart aiming to accelerate its subcutaneous absorption. The aim of this study was to compare pharmacokinetics of faster insulin aspart versus standard ...

Phytogenic polyphenols as glycogen phosphorylase inhibitors: The potential of triterpenes and flavonoids for glycaemic control in type 2 diabetes

Stravodimos G.A., Chetter B.A., Kyriakis E., Kantsadi A.L., Chatzileontiadou D.S.M., Skamnaki V.T., Kato A., Hayes J.M., Leonidas D.D. (2017)

Glycogen phosphorylase (GP) is a validated pharmaceutical target for the development of antihyperglycaemic agents. Phytogenic polyphenols, mainly flavonoids and pentacyclic triterpenes, have been found to be potent inhibitors ...

Quality of life in subjects with type 2 diabetes mellitus with diabetic retinopathy: A case–control study

Ligda G., Ploubidis D., Foteli S., Kontou P.I., Nikolaou C., Tentolouris N. (2019)

Aims: Diabetic retinopathy (DR) as a common complication of Type 2 Diabetes Mellitus (T2DM) affecting negatively quality of life (QoL). Assessing of QoL in patients with DR is a prerequisite for the evaluation of their ...

Real-World Adequacy of Glycaemic Control in Treatment-Naïve Greek Patients with Type 2 Diabetes Mellitus Initiating Treatment with Metformin Monotherapy at the Maximum Tolerated Dose: The Reload Study

Tsimihodimos V., Bargiota A., Pagkalos E.M., Manes C., Papas A., Karamousouli E., Voss B., Elisaf M.S. (2020)

Background Metformin, in the absence of contraindications or intolerance, is recommended as first-line treatment for patients with type 2 diabetes mellitus (T2DM). This observational, retrospective study assessed the ...