Browsing by Subject "UNSATURATED KETONUCLEOSIDES"

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Dideoxy fluoro-ketopyranosyl nucleosides as potent antiviral agents: Synthesis and biological evaluation of 2,3-and 3,4-dideoxy-3-fluoro-4-and-2-keto-beta-D-glucopyranosyl derivatives of N-4-benzoyl cytosine

Manta, S.; Tsoukala, E.; Tzioumaki, N.; Goropevsek, A.; Pamulapati, R. T.; Cencic, A.; Balzarini, J.; Komiotis, D. (2009)

The synthesis of the dideoxy fluoro ketopyramonucleoside analogues, 1-(2,3-dideoxy-3-fluoro-6-O-trityl-beta-D-glycero-hexopyranosyl-4-ulose)-N-4-benzoyl cytosine (7a), 1-(3,4-dideoxy-3-fluoro-6-O-trityl-beta-D-glycero-he ...
Exomethylene pyranonucleosides: Efficient synthesis and biological evaluation of 1-(2,3,4-trideoxy-2-methylene-beta-D-glycero-hex-3-enopyranosyl)thymine

Agelis, G.; Tzioumaki, N.; Boti, T.; Cencic, A. A.; Komiotis, D. (2007)

A new series of unsaturated pyranonucleosides with an exocyclic methylene group and thymine as heterocyclic base have been designed and synthesized. D-Galactose (1) was readily transformed in three steps into the corresponding ...
Keto and Exomethylene Pyranonucleosides as Antitumor Agents

Tsoukala, E.; Manta, S.; Kiritsis, C.; Komiotis, D. (2012)

Nucleosides and their analogues take an important place in medicinal chemistry as the structural basis for the development of therapeutic agents. Recently, there has been a renewed interest in the synthesis of keto and ...