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Parcourir par sujet "Systemic sclerosis"

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    • Autoantibodies in patients with systemic sclerosis and cancer: A case-control study 

      Derk, C. T.; Sakkas, L. I.; Rasheed, M.; Artlett, C.; Jimenez, S. A. (2003)
      Objective. To determine the prevalence of specific autoantibodies in a cohort of patients with systemic sclerosis (SSc) and a diagnosis of cancer, and to compare it to that in a group of patients with SSc who were never ...

    • Incident Atrial Fibrillation in Systemic Sclerosis: The Predictive Role of B-Type Natriuretic Peptide 

      Giallafos, I.; Triposkiadis, F.; Oikonomou, E.; Giamouzis, G.; Aggeli, K.; Konstantopoulou, P.; Kouranos, V.; Mavrikakis, M.; Giallafos, J.; Stefanadis, C.; Sfikakis, P. P. (2014)
      Introduction: Atrial fibrillation (AF) is common in patients with systemic sclerosis (SSc) and is associated with significant morbidity, mortality, and healthcare expenditures. The aim of this study was to prospectively ...

    • Intravenous immunoglobulins (IVIG) in systemic sclerosis: a challenging yet promising future 

      Cantarini, L.; Rigante, D.; Vitale, A.; Napodano, S.; Sakkas, L. I.; Bogdanos, D. P.; Shoenfeld, Y. (2015)
      The etiology and pathogenesis of systemic sclerosis are still largely unknown, but a variety of humoral and cellular autoimmune phenomena have been documented. In addition, the rarity of the disease, the broad spectrum of ...

    • Mycophenolate mofetil in systemic sclerosis-associated interstitial lung disease 

      Koutroumpas, A.; Ziogas, A.; Alexiou, I.; Barouta, G.; Sakkas, L. I. (2010)
      This study aimed to assess the effect of mofetil mycophenolate (MMF), an inhibitor of lymphocyte proliferation, on lung function and skin in patients with systemic sclerosis (SSc)-associated interstitial lung disease ...

    • Systemic sclerosis: From pathogenesis towards targeted immunotherapies 

      Sakkas, L. I.; Chikanza, I. C.; Platsoucas, C. D. (2012)
      Systemic sclerosis (SSc), a chronic disease with widespread collagen deposition, has three pathogenetic facets: immune activation, microvasculopathy and fibroblast activation. Immune activation and microvasculopathy occur ...

    • T-cells and B-cells in systemic sclerosis 

      Sakkas, L. I.; Platsoucas, C. D. (2010)
      Systemic sclerosis (SSc) is characterized by activation of fibroblasts with extensive deposition of collagen, by small vessel vasculopathy with fibrointimal proliferation, and activation of the immune system, with hyper-γ- ...