Browsing by Subject "MUTATION"
Now showing items 1-18 of 18
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Association of KLOTHO Gene Polymorphisms with Knee Osteoarthritis in Greek Population
(2008)Based on the fact that klotho-deficient mice exhibit multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints and on the recent observation that KLOTHO gene plays an important role in calcium/phosphate ... -
A classification system based on a new wrapper feature selection algorithm for the diagnosis of primary and secondary polycythemia
(2013)Primary and Secondary Polycythemia are diseases of the bone marrow that affect the blood's composition and prohibit patients from becoming blood donors. Since these diseases may become fatal, their early diagnosis is ... -
DNA methylation regulates sclerostin (SOST) expression in osteoarthritic chondrocytes by bone morphogenetic protein 2 (BMP-2) induced changes in Smads binding affinity to the CpG region of SOST promoter
(2015)Introduction: Sclerostin (SOST), a soluble antagonist of Wnt signaling, is expressed in chondrocytes and contributes to chondrocytes' hypertrophic differentiation; however its role in osteoarthritis (OA) pathogenesis is ... -
Evaluation of toxicity and genotoxic effects of spinosad and deltamethrin in Drosophila melanogaster and Bactrocera oleae
(2011)BACKGROUND: The insecticides spinosad and deltamethrin are being increasingly used in pest management programmes. In order to assess further their toxic effects to target and non-target insect species, an evaluation was ... -
Genetic analysis of C5a receptors in neutrophils from patients with familial Mediterranean fever
(2012)Familial Mediterranean fever (FMF) is an autoinflammatory disease, characterized by MEFV gene mutations and self-limited recurrent episodes of fever and localized serositis. Complement system is a key regulator of the ... -
Genetic evidence for introgression between domestic pigs and wild boars (Sus scrofa) in Belgium and Luxembourg: a comparative approach with multiple marker systems
(2013)Hybridization between wild species and their domestic relatives can be an important conservation and management problem. Genetic purity of the wild species is desirable per se and the phenomenon can have unpredictable ... -
Glutathione S-transferase polymorphisms and onset age in alpha-synuclein A53T mutant Parkinson's disease
(2007)Monogenic forms of Parkinson's disease (PD) provide an opportunity to examine mechanisms underlying phenotypic variation. Glutathione S-transferase (GST) has detoxification and antioxidative functions. To screen genetic ... -
How genetics research in Parkinson's disease is enhancing understanding of the common idiopathic forms of the disease
(2005)Purpose of review Rapid progress in genetics has meant that there are now five genes identified for 'Parkinson's disease'. The detailed phenotypes vary, but generally the dominant genes cause a Lewy body disease spectrum ... -
Insecticide resistance status of Myzus persicae (Hemiptera : Aphididae) populations from peach and tobacco in mainland Greece
(2007)The susceptibility of 88 and 38 field samples of Myzus persicae (Sulzer) to imidacloprid and deltamethrin respectively was examined using the FAO dip test bioassay. The field samples were collected from tobacco and peach ... -
Maternal gene polymorphisms involved in folate metabolism and risk of Down syndrome offspring: a meta-analysis
(2007)Studies investigating the association between gene polymorphisms involved in homocysteine/folate metabolism and Down syndrome (DS) have reported contradictory or inconclusive results. A meta-analysis of 11 case-control ... -
Mitochondrial tRNA mutations - Clinical and functional perturbations
(2007)During the last decade, there has been a progressive accumulation of reports that connect the identification of specific mitochondrial tRNA gene mutations to severe disorders in human. As a result, mitochondrial tRNA genes ... -
Phylogeography of the rock partridge (Alectoris graeca)
(2003)We used mitochondrial DNA control-region and microsatellite data to infer the evolutionary history and past demographic changes in 332 rock partridges (Alectoris graeca ) sampled from throughout the species' distribution ... -
Shikimate leaf disc assay for early detection of glyphosate resistance in Conyza canadensis and relative transcript levels of EPSPS and ABC transporter genes
(2012)Nol N, Tsikou D, Eid M, Livieratos IC & Giannopolitis CN (2012). Shikimate leaf disc assay for early detection of glyphosate resistance in Conyza canadensis and relative transcript levels of EPSPS and ABC transporter genes. ... -
TACI Expression and Signaling in Chronic Lymphocytic Leukemia
(2015)TACI is a membrane receptor of BAFF and APRIL, contributing to the differentiation and survival of normal B cells. Although malignant B cells are also subjected on TACI signaling, there is a remarkable intradisease and ... -
Testing association between LRRK2 and Parkinson's disease and investigating linkage disequilibrium
(2006)Background: We and others recently identified the gene underlying PARK8 linked Parkinson's disease (PD). This gene, LRRK2, contains mutations that cause an autosomal dominant PD, including a mutation, G2019S, which is the ... -
The use of comet assay in measuring DNA damage and repair efficiency in child, adult, and old age populations
(2009)In the present study, we used the Comet assay to estimate basal DNA damage in three distinct populations aged 5-10, 40-50, and 60-70 years old. The DNA damage induced by hydrogen peroxide and gamma-irradiation in the ... -
Wide dissemination of linezolid-resistant Staphylococcus epidermidis in Greece is associated with a linezolid-dependent ST22 clone
(2015)Objectives: Dependence on linezolid was recently described as significant growth acceleration of linezolid-resistant Staphylococcus epidermidis (LRSE) isolates upon linezolid exposure. We investigated the possible contribution ...