Listar por tema "LYMPHOCYTES"
Mostrando ítems 1-10 de 10
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The HIV-1 gp120/V3 modifies the response of uninfected CD4 T cells to antigen presentation: mapping of the specific transcriptional signature
(2011)Background: The asymptomatic phase of HIV-1 infection is characterized by a progressive depletion of uninfected peripheral effector/memory CD4+ T cells that subsequently leads to immune dysfunction and AIDS symptoms. We ... -
HIV-1 gp120/V3-derived epitopes promote activation-induced cell death to superantigen-stimulated CD4(+)/CD45RO(+) T cells
(2007)The third hypervirable (V3) domain of the HIV-1 envelope glycoprotein gp120 has been implicated in HIV pathogenesis via co-receptor usage of chemokine receptors CCR5 and CXCR4. As the protagonist cell populations in the ... -
Perforin down-regulation and adhesion molecules activation in pulmonary sarcoidosis - An induced sputum and BAL study
(2006)Background. Sarcoidosis is drought to be a T-helper type 1 cytokine-mediated disorder. Sputum induction has been proposed as a useful noninvasive method mainly for the assessment of airway diseases. However, it is unknown ... -
Presence of sub-epithelial lymphoid tissues in the teat of ewe-lambs and adult ewes
(2007)In the first part of the study, 24 clinically healthy teats from non-lactating ewe-lambs were examined bacteriologically and histologically. No bacteria were isolated from any of these teats; lymphocytes were observed in ... -
Primary CD30-positive cutaneous T-cell lymphomas and lymphomatoid papulosis frequently express cytotoxic proteins
(2000)Alms: To analyse the relationship between expression of cytotoxic proteins. histopathology and the CD30 status in primary cutaneous T-cell disorders, we investigated the expression of TIA-1, granzyme B and perforin in CD30 ... -
A study of zearalenone cytotoxicity on human peripheral blood mononuclear cells
(2006)The mycotoxin zearalenone (ZEA) is a common contaminant of all major cereal grains worldwide with estrogenic and anabolic activity. We investigated the in vitro cytopathic effects of ZEA on freshly isolated human peripheral ... -
Telomere Length in Peripheral Blood Mononuclear Cells of Patients on Chronic Hemodialysis Is Related With Telomerase Activity and Treatment Duration
(2015)Telomere shortening to a critical limit is associated with replicative senescence. This process is prevented by the enzyme telomerase. Oxidative stress and chronic inflammation are factors accelerating telomere loss. Chronic ... -
Urate crystals induce NLRP3 inflammasome-dependent IL-1 beta secretion and proliferation in isolated primary human T-cells
(2015)Background: Urate through NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome-dependent caspase-1 activation stimulates macrophages to secrete inteleukin-1 beta (IL-1 beta). Urate also enhances adaptive ...