Parcourir par sujet "FACTOR-1-ALPHA"
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Casein kinase 1 regulates human hypoxia-inducible factor HIF-1
(2010)Hypoxia-inducible factor 1 (HIF-1), a transcriptional activator that mediates cellular response to hypoxia and a promising target of anticancer therapy, is essential for adaptation to low oxygen conditions, embryogenesis ... -
Differential expression of hypoxia-inducible factor 1 alpha in non-small cell lung cancer and small cell lung cancer
(2012)OBJECTIVES: The aim of this study was to compare the expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor in small cell lung cancer and subtypes of non-small cell lung cancer and examine ... -
Exposure of differentiated airway smooth muscle cells to serum stimulates both induction of hypoxia-inducible factor-1 alpha and airway responsiveness to ACh
(2007)Airway smooth muscle (ASM) cells are characterized by phenotypic plasticity and can switch between differentiated and proliferative phenotypes. In rabbit tracheal ASM cells that had been differentiated in vitro by serum ... -
TNF alpha induces expression of HIF-1 mRNA and protein but inhibits hypoxic stimulation of HIF-1 alpha transcriptional activity in airway smooth muscle cells
(2013)Airway smooth muscle cells (ASMCs) participate in tissue remodeling characteristic of airway inflammatory diseases like asthma. Inflammation and hypoxia pathways are often interconnected and the regulatory subunit of the ...