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    • Dual IRE1 RNase functions dictate glioblastoma development 

      Lhomond S., Avril T., Dejeans N., Voutetakis K., Doultsinos D., McMahon M., Pineau R., Obacz J., Papadodima O., Jouan F., Bourien H., Logotheti M., Jégou G., Pallares-Lupon N., Schmit K., Le Reste P.-J., Etcheverry A., Mosser J., Barroso K., Vauléon E., Maurel M., Samali A., Patterson J.B., Pluquet O., Hetz C., Quillien V., Chatziioannou A., Chevet E. (2018)
      Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical ...

    • Editorial: Role of Ribonucleases in Immune Response Regulation During Infection and Cancer 

      Boix E., Acquati F., Leonidas D., Pulido D. (2020)
      [No abstract available]

    • Kinetics of inhibition of ribonuclease P activity by peptidyltransferase inhibitors: Effect of antibiotics on RNase P 

      Kalavrizioti, D.; Vourekas, A.; Tekos, A.; Tsagla, A.; Stathopoulos, C.; Drainas, D. (2003)
      A cell-free system derived from Dictyostelium discoideum has been used to study the kinetics of inhibition of RNase P by puromycin, amicetin and blasticidin S. Detailed kinetic analysis showed that the type of inhibition ...

    • Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance 

      Rubio-Patiño C., Bossowski J.P., De Donatis G.M., Mondragón L., Villa E., Aira L.E., Chiche J., Mhaidly R., Lebeaupin C., Marchetti S., Voutetakis K., Chatziioannou A., Castelli F.A., Lamourette P., Chu-Van E., Fenaille F., Avril T., Passeron T., Patterson J.B., Verhoeyen E., Bailly-Maitre B., Chevet E., Ricci J.-E. (2018)
      Dietary restriction (DR) was shown to impact on tumor growth with very variable effects depending on the cancer type. However, how DR limits cancer progression remains largely unknown. Here, we demonstrate that feeding ...

    • Transcription of the NKG2D ligand MICA is suppressed by the IRE1/XBP1 pathway of the unfolded protein response through the regulation of E2F1 

      Obiedat A., Seidel E., Mahameed M., Bernani O., Tsukerman P., Voutetakis K., Chatziioannou A., Mcmahon M., Avril T., Chevet E., Mandelboim O., Tirosh B. (2019)
      The unfolded protein response (UPR) is an adaptive signaling pathway activated in response to endoplasmic reticulum (ER) stress. The effectors of the UPR are potent transcription activators; however, some genes are suppressed ...