Listar por tema "DNA topoisomerase"

A bioinformatics analysis reveals novel pathogens as molecular mimicry triggers of systemic sclerosis

Gkoutzourelas A., Barmakoudi M., Bogdanos D.P. (2020)

A recent bioinformatic analysis revealing dominant B cell epitopes of systemic sclerosis-specific autoantibodies, including anti-centromere B, anti-topoisomerase I and anti-fibrillarin, has demonstrated the existence of ...

Disease-related autoantibody profile in patients with systemic sclerosis

Liaskos C., Marou E., Simopoulou T., Barmakoudi M., Efthymiou G., Scheper T., Meyer W., Bogdanos D.P., Sakkas L.I. (2017)

Background: Autoantibodies (autoAbs) help in diagnosis and predicting clinical phenotypes in systemic sclerosis (SSc). Aim of the study: To determine the clinical utility of 13 SSc-related autoAbs in SSc patients. Material ...

Effect of Leguminosae family plant extracts and polyphenolic fractions on topoisomerase I-induced nicking of DNA

Spanou, C.; Aligiannis, N.; Skaltsounis, A. L.; Kouretas, D. (2008)

Topoisomerase I constitutes one of the enzymes playing crucial role in replication, transcription, recombination, chromosome condensation and maintenance of genome stability. Because it is an essential enzyme for vital ...

Effects of plant phenolics and grape extracts from Greek varieties of Vitis vinifera on Mitomycin C and topoisomerase I-induced nicking of DNA

Stagos, D.; Kazantzoglou, G.; Magiatis, P.; Mitaku, S.; Anagnostopoulos, K.; Kouretas, D. (2005)

In recent years, a number of reports have shown the anticancer activity of grape extracts and wine against various types of cancer such as breast, lung and gastric cancer. This property is mainly attributed to the plant ...

IL-10-producing regulatory B cells (B10 cells), IL-17 + T cells and autoantibodies in systemic sclerosis

Mavropoulos A., Liaskos C., Simopoulou T., Bogdanos D.P., Sakkas L.I. (2017)

We aimed to analyze IL-10 + Breg (B10) cells, found to be reduced in systemic sclerosis (SSc), in relation to SSc-specific autoAbs and IL-17 + and IFNγ + T cells in SSc. Peripheral blood B10 cells from 26 patients with SSc ...

Multiparametric autoantibody profiling of patients with systemic sclerosis in Greece

Liaskos C., Marou E., Simopoulou T., Gkoutzourelas A., Barmakoudi M., Efthymiou G., Scheper T., Meyer W., Katsiari C.G., Bogdanos D.P., Sakkas L.I. (2018)

Background: Systemic sclerosis (SSc) is an autoimmune rheumatic disease characterized by a wide range of disease-specific and disease-related autoantibodies (autoAbs). Profile assays have been developed and are currently ...