Sfoglia per Autore "Kotsakis, S. D."
Items 1-3 di 3
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Characterization of Metallo-beta-Lactamase VIM-27, an A57S Mutant of VIM-1 Associated with Klebsiella pneumoniae ST147
Papagiannitsis, C. C.; Kotsakis, S. D.; Petinaki, E.; Vatopoulos, A. C.; Tzelepi, E.; Miriagou, V.; Tzouvelekis, L. S. (2011)VIM-27 metallo-beta-lactamase, an Ala(57) -> Ser variant of VIM-1, was identified in three Klebsiella pneumoniae isolates belonging to sequence type 147. bla(VIM-27) was part of a class 1 integron carried by non-self-transferable ... -
Effects of the Val211Gly substitution on molecular dynamics of the CMY-2 cephalosporinase: Implications on hydrolysis of expanded-spectrum cephalosporins
Kotsakis, S. D.; Tzouvelekis, L. S.; Petinaki, E.; Tzelepi, E.; Miriagou, V. (2011)CMY-30, a naturally occurring class C beta-lactamase differing from the Citrobacter freundii-derived CMY-2 by a Val211Gly substitution in the X-loop, exhibits increased hydrolytic efficiency against ceftazidime and cefotaxime. ... -
Interactions of Oximino-Substituted Boronic Acids and beta-Lactams with the CMY-2-Derived Extended-Spectrum Cephalosporinases CMY-30 and CMY-42
Kotsakis, S. D.; Caselli, E.; Tzouvelekis, L. S.; Petinaki, E.; Prati, F.; Miriagou, V. (2013)CMY-30 and CMY-42 are extended-spectrum (ES) derivatives of CMY-2. ES characteristics are due to substitutions of Gly (CMY-30) and Ser (CMY-42) for Val211 in the Omega-loop. To characterize the effects of 211 substitutions, ...