• Adrenomedullin optimises mortality prediction in COPD patients 

      Brusse-Keizer, M.; Zuur-Telgen, M.; van der Palen, J.; VanderValk, P.; Kerstjens, H.; Boersma, W.; Blasi, F.; Kostikas, K.; Milenkovic, B.; Tamm, M.; Stolz, D. (2015)
      Background: Current multicomponent scores that predict mortality in COPD patients might underestimate the systemic component of COPD. Therefore, we evaluated the accuracy of circulating levels of proadrenomedullin (MR-proADM) ...
    • Adrenomedullin refines mortality prediction by the BODE index in COPD: the "BODE-A" index 

      Stolz, D.; Kostikas, K.; Blasi, F.; Boersma, W.; Milenkovic, B.; Lacoma, A.; Louis, R.; Aerts, J. G.; Welte, T.; Torres, A.; Rohde, G. G. U.; Boeck, L.; Rakic, J.; Scherr, A.; Hertel, S.; Giersdorf, S.; Tamm, M. (2014)
      The BODE (body mass index, airflow obstruction, dyspnoea, exercise capacity) index is well-validated for mortality prediction in chronic obstructive pulmonary disease (COPD). Concentrations of plasma pro-adrenomedullin, a ...
    • Exertional Hypoxemia in Stable COPD Is Common and Predicted by Circulating Proadrenomedullin 

      Stolz, D.; Boersma, W.; Blasi, F.; Louis, R.; Milenkovic, B.; Kostikas, K.; Aerts, J. G.; Rohde, G.; Lacoma, A.; Rakic, J.; Boeck, L.; Castellotti, P.; Scherr, A.; Marin, A.; Hertel, S.; Giersdorf, S.; Torres, A.; Welte, T.; Tamm, M. (2014)
      BACKGROUND: The prevalence of exertional hypoxemia in unselected patients with COPD is unknown. Intermittent hypoxia leads to adrenomedullin (ADM) upregulation through the hypoxia-inducible factor-1 pathway. We aimed to ...