Πλοήγηση ανά Θέμα "animal cell"

Evidence of functional deficits at the single muscle fiber level in experimentally-induced renal insufficiency

Mitrou G.I., Sakkas G.K., Poulianiti K.P., Karioti A., Tepetes K., Christodoulidis G., Giakas G., Stefanidis I., Geeves M.A., Koutedakis Y., Karatzaferi C. (2019)

Chronic kidney disease patients present with metabolic and functional muscle abnormalities, called uremic myopathy, whose mechanisms have not yet been fully elucidated. We investigated whether chronic renal insufficiency ...

Excitement-induced cutaneous bleeding (Haematidrosis-like) in a dog

Sofou E.I., Gavra A., Saridomichelakis M.N. (2021)

A 15-month-old intact female Pitbull was referred because of recurrent, episodic, self-limiting, excitement-induced bleeding from nontraumatised skin. No abnormalities were detected upon physical examination. Subsequently, ...

Experimental study for evaluation of the efficacy of a biofilm-embedded bacteria-based vaccine against Staphylococcus chromogenes-associated mastitis in sheep

Vasileiou N.G.C., Cripps P.J., Ioannidi K.S., Katsafadou A.I., Chatzopoulos D.C., Barbagianni M.S., Tsioli V., Dermisiadou E., Karavanis E., Papadopoulos N., Lianou D.T., Mavrogianni V.S., Petinaki E., Fthenakis G.C. (2019)

Although coagulase-negative staphylococci are the primary aetiological agents of subclinical mastitis in ewes, there is little information regarding vaccination against that infection. The objective of this study was to ...

Experimental study of the potential role of salmonella enterica subsp. Diarizonae in the diarrhoeic syndrome of lambs

Chatzopoulos D.C., Vasileiou N.G.C., Ioannidi K.S., Katsafadou A.I., Mavrogianni V.S., Michael C.K., Katsarou E.I., Karavanis E., Papadopoulos N., Sbiraki A., Athanasiou L.V., Billinis C., Fthenakis G.C. (2021)

The objectives of this experimental work were the evaluation of the potential role of Salmonella enterica subsp. diarizonae in diarrhoeic syndrome in lambs and the investigation of facets of the pathogenesis of the infection. ...

Exploring the potential of mucin 13 (MUC13) as a biomarker for carcinomas and other diseases

Filippou P.S., Ren A.H., Korbakis D., Dimitrakopoulos L., Soosaipillai A., Barak V., Frenkel S., Pe'Er J., Lotem M., Merims S., Molina R., Blasutig I., Bogdanos D.P., Diamandis E.P. (2018)

Mucin 13 (MUC13) is a cell surface glycoprotein aberrantly expressed in a variety of epithelial carcinomas. Thus far, the role of MUC13 in various diseases remains elusive. To the best of our knowledge, this is the first ...

Functional characterization of the hGRαT556I causing Chrousos syndrome

Nicolaides N.C., Skyrla E., Vlachakis D., Psarra A.-M.G., Moutsatsou P., Sertedaki A., Kossida S., Charmandari E. (2016)

Background: Chrousos syndrome is a rare pathologic condition characterized by generalized, partial resistance of target tissues to glucocorticoids and caused by inactivating mutations of the human glucocorticoid receptor ...

Functional expression of mammalian opioid receptors in insect cells and high-throughput screening platforms for receptor ligand mimetics

Swevers, L.; Morou, E.; Balatsos, N.; Iatrou, K.; Georgoussi, Z. (2005)

Lepidopteran cell lines have been engineered to constitutively express high levels of mouse δ opioid receptors either alone or in combination with human Gα16 protein. Biochemical and pharmacological studies demonstrate ...

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis

Müller T., Alberts R., De Vries E.M.G., Goode E.C., Jiang X., Sampaziotis F., Rombouts K., Böttcher K., Folseraas T., Weismüller T.J., Mason A.L., Wang W., Alexander G., Alvaro D., Bergquist A., Björkström N.K., Beuers U., Björnsson E., Boberg K.M., Bowlus C.L., Bragazzi M.C., Carbone M., Chazouillères O., Cheung A., Dalekos G., Eaton J., Eksteen B., Ellinghaus D., Färkkilä M., Festen E.A.M., Floreani A., Franceschet I., Gotthardt D.N., Hirschfield G.M., Hoek B.V., Holm K., Hohenester S., Hov J.R., Imhann F., Invernizzi P., Juran B.D., Lenzen H., Lieb W., Liu J.Z., Marschall H.-U., Marzioni M., Melum E., Milkiewicz P., Pares A., Rupp C., Rust C., Sandford R.N., Schramm C., Schreiber S., Schrumpf E., Silverberg M.S., Srivastava B., Sterneck M., Teufel A., Vallier L., Verheij J., Vila A.V., De Vries B., Zachou K., Chapman R.W., Manns M.P., Pinzani M., Rushbrook S.M., Lazaridis K.N., Franke A., Anderson C.A., Karlsen T.H., Ponsioen C.Y., Weersma R.K. (2018)

Objective Primary sclerosing cholangitis (PSC) is a genetically complex, inflammatory bile duct disease of largely unknown aetiology often leading to liver transplantation or death. Little is known about the genetic ...

Genetic polymorphism of canine cytochrome P450 2D25 gene

Pappas, I. S.; Katsiabas, D. S. (2004)

Human CYP2D6 is involved in the metabolism of a number of drugs including neuroleptics, tricyclic antidepressants, β-adrenoreceptors antagonists and antiarrhythmic drugs. The corresponding canine CYP2D15 have shown similar ...

A gravity-based three-dimensional compass in the mouse brain

Angelaki D.E., Ng J., Abrego A.M., Cham H.X., Asprodini E.K., Dickman J.D., Laurens J. (2020)

Gravity sensing provides a robust verticality signal for three-dimensional navigation. Head direction cells in the mammalian limbic system implement an allocentric neuronal compass. Here we show that head-direction cells ...

Haematology reference values for Dicentrarchus labrax and Sparus aurata: A systematic review and meta-analysis

Michail G., Berillis P., Nakas C., Henry M., Mente E. (2022)

Haematological parameters are frequently used as physiological indicators in aquaculture studies. These parameters also have extended applications in clinical evaluation, diagnosis and prognosis in fish health status. ...

Healthspan improvement and anti-aggregation effects induced by a marine-derived structural proteasome activator

Vasilopoulou M.A., Gioran A., Theodoropoulou M., Koutsaviti A., Roussis V., Ioannou E., Chondrogianni N. (2022)

Proteasome activation has been shown to promote cellular and organismal healthspan and to protect against aggregation-related conditions, such as Alzheimer's disease (AD). Various natural compounds have been described for ...

Humoral response in experimental autoimmune encephalomyelitis targets neural precursor cells in the central nervous system of naive rodents

Kesidou E., Touloumi O., Lagoudaki R., Nousiopoulou E., Theotokis P., Poulatsidou K.-N., Boziki M., Kofidou E., Delivanoglou N., Minti F., Hadjigeorgiou G., Grigoriadis N., Simeonidou C. (2017)

Background: Neural precursor cells (NPCs) located in the subventricular zone (SVZ), a well-defined NPC niche, play a crucial role in central nervous system (CNS) homeostasis. Moreover, NPCs are involved in the endogenous ...

Immunohistochemical Expression of Keratins in Normal Ovine Skin and in Chronic Dermatitis due to Sarcoptes scabiei

Doukas D., Liakou Z., Koukoulis G.K., Tontis D. (2021)

Hyperproliferation of epidermal keratinocytes is a major histopathological feature of chronic Sarcoptes scabiei dermatitis. We investigated the immunohistochemical expression of several keratins in scabietic dermatitis in ...

In vivo base editing by a single i.v. vector injection for treatment of hemoglobinopathies

Li C., Georgakopoulou A., Newby G.A., Everette K.A., Nizamis E., Paschoudi K., Vlachaki E., Gil S., Anderson A.K., Koob T., Huang L., Wang H., Kiem H.-P., Liu D.R., Yannaki E., Lieber A. (2022)

Individuals with β-thalassemia or sickle cell disease and hereditary persistence of fetal hemoglobin (HPFH) possessing 30% fetal hemoglobin (HbF) appear to be symptom free. Here, we used a nonintegrating HDAd5/35++ vector ...

Induced Collagen Cross-Links Enhance Cartilage Integration

Athens, A. A.; Makris, E. A.; Hu, J. C. (2013)

Articular cartilage does not integrate due primarily to a scarcity of cross-links and viable cells at the interface. The objective of this study was to test the hypothesis that lysyl-oxidase, a metalloenzyme that forms ...

Insulin causes a transient induction of proliferation via activation of the PI3-kinase pathway in airway smooth muscle cells

Papagianni, M.; Hatziefthimiou, A.; Chachami, G.; Gourgoulianis, K.; Molyvdas, P. A.; Paraskeva, E. (2007)

Insulin regulates glucose metabolism and activates cell growth. As the respiratory system is an alternative route for insulin administration in patients with diabetes mellitus, we studied the effect of insulin on rabbit ...

Investigation of the chemical profile and cytotoxicity evaluation of organic components eluted from pit and fissure sealants

Koulaouzidou E.A., Roussou K., Sidiropoulos K., Nikolaidis A., Kolokuris I., Tsakalof A., Tsitsimpikou C., Kouretas D. (2018)

The aim of this study was to identify organic components eluted from five resin dental sealants using gas chromatography and mass spectrometry (GC/MS) after 1-day and 40-days storage and the effect of sealants on cell ...

Irisin regulates thermogenesis and lipolysis in 3T3-L1 adipocytes

Vliora M., Grillo E., Corsini M., Ravelli C., Nintou E., Karligiotou E., Flouris A.D., Mitola S. (2022)

Background: Adipose tissue plays a pivotal role in the development and progression of the metabolic syndrome which along with its complications is an epidemic of the 21st century. Irisin is an adipo-myokine secreted mainly ...

Isolation of oxamyl-degrading bacteria and identification of cehA as a novel oxamyl hydrolase gene

Rousidou K., Chanika E., Georgiadou D., Soueref E., Katsarou D., Kolovos P., Ntougias S., Tourna M., Tzortzakakis E.A., Karpouzas D.G. (2016)

Microbial degradation is the main process controlling the environmental dissipation of the nematicide oxamyl. Despite that, little is known regarding the microorganisms involved in its biotransformation. We report the ...