Πλοήγηση ανά Θέμα "Academic Press Inc."
Αποτελέσματα 41-60 από 61
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The novel dehydroepiandrosterone (DHEA) derivative BNN27 counteracts delay-dependent and scopolamine-induced recognition memory deficitsm in rats
(2017)Experimental evidence indicates that the neurosteroids dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) are involved in cognition. BNN27 is a novel 17C spiroepoxy-DHEA derivative, which devoid of ... -
Pesticide exposure and cognitive function: Results from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD)
(2019)Background: Results from studies to date, regarding the role of chronic pesticide exposure on cognitive function remain contradictory. Objective: To investigate the relationship between self-reported pesticide exposure and ... -
Pesticides and cardiotoxicity. Where do we stand?
(2018)Cardiovascular diseases are among the most significant causes of mortality in humans. Pesticides toxicity and risk for human health are controlled at a European level through a well-developed regulatory network, but ... -
Phytoestrogens, phytosteroids and saponins in vegetables: Biosynthesis, functions, health effects and practical applications
(2019)Phytoestrogens are non-steroidal secondary metabolites with similarities in structure and biological activities with human estrogens divided into various classes of compounds, including lignans, isoflavones, ellagitannins, ... -
Post-translational modifications of Medicago truncatula glutathione peroxidase 1 induced by nitric oxide
(2017)Plant glutathione peroxidases (Gpx) catalyse the reduction of various peroxides, such as hydrogen peroxide (H2O2), phospholipid hydroperoxides and peroxynitrite, but at the expense of thioredoxins rather than glutathione. ... -
Potentially irreversible olfactory and gustatory impairments in COVID-19: Indolent vs. fulminant SARS-CoV-2 neuroinfection
(2020)[No abstract available] -
The powerful Solanaceae: Food and nutraceutical applications in a sustainable world
(2022)The Solanaceae family is considered one of the most important families among plant species because, on one hand encompasses many staple food crops of the human diet while, on the other hand, it includes species rich in ... -
Probing the β-pocket of the active site of human liver glycogen phosphorylase with 3-(C-β-D-glucopyranosyl)-5-(4-substituted-phenyl)-1, 2, 4-triazole inhibitors
(2018)Human liver glycogen phosphorylase (hlGP), a key enzyme in glycogen metabolism, is a valid pharmaceutical target for the development of new anti-hyperglycaemic agents for type 2 diabetes. Inhibitor discovery studies have ... -
Protein phosphatase PPP3CA (calcineurin A) down-regulates hypoxia-inducible factor transcriptional activity
(2019)Hypoxia-inducible factors (HIF) are master regulators of the response to hypoxia. Although several kinases are known to modify their oxygen sensitive HIF-α subunits or affect indirectly their function, little is known about ... -
Repeated but not acute exposure with a low dose range of the nitric oxide (NO) donor sodium nitroprusside (SNP) induces anxiolytic-like behaviour in a dose-independent manner in two different rat models of anxiety
(2020)Sodium nitroprusside (SNP) is a nitric oxide (NO) donor which actually is under assessment as a potential candidate for the treatment of schizophrenia. It is well documented that anxiety symptoms are a prominent future in ... -
The role of exhaled nitric oxide in patients with chronic obstructive pulmonary disease undergoing laparotomy surgery – The noxious study
(2016)Background Chronic Obstructive Pulmonary Disease (COPD) has been associated with major perioperative morbidities or mortalities, especially in surgical patients receiving general anesthesia. The severity of the COPD and ... -
The role of nitric oxide (NO) donors in anxiety. Lights and shadows
(2018)Anxiety-related disorders are a common public health issues. Current medication for this affective disorder involves the GABA-ergic or the serotonergic transmission. Different forms of anxiety, however, are resistant to ... -
Serum levels of organochlorine pesticides in the general population of Thessaly, Greece, determined by HS-SPME GC-MS method
(2016)In this study, exposure levels of organochlorine pesticides (OCs) were determined in general population residing in Larissa, central Greece. Serum samples from 103 volunteers were analyzed by optimized headspace solid-phase ... -
Sleep quality and duration in relation to memory in the elderly: Initial results from the Hellenic Longitudinal Investigation of Aging and Diet
(2017)Background Sleep is crucial for cognition, particularly for memory, given its complex association with neurodegenerative processes. The aim of the present study was to examine the association between sleep quality as well ... -
A statistical analysis for RF-EMF exposure levels in sensitive land use: A novel study in Greek primary and secondary education schools
(2020)Background: The increasing popularity of mobile phones and the expansion of network infrastructure in Greece have given rise to public concerns about potential adverse health effects on sensitive groups, such as children, ... -
Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors
(2020)Glycogen phosphorylase (GP) is an important target for the development of new anti-hyperglycaemic agents. Flavonoids are novel inhibitors of GP, but their mode of action is unspecific in terms of the GP binding sites ... -
Tile caching for scalable VR video streaming over 5G mobile networks
(2021)Currently, VR video delivery over 5G systems is still a very complicated endeavor. One of the major challenges for VR video streaming is the expectations for low latency that current mobile networks can hardly meet. Network ... -
Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin
(2015)Eosinophil derived neurotoxin (EDN) is an eosinophil secretion protein and a member of the Ribonuclease A (RNase A) superfamily involved in the immune response system and inflammatory disorders. The pathological actions ... -
Using a modified 3D-printer for mapping the magnetic field of RF coils designed for fetal and neonatal imaging
(2016)An experimental setup for characterizing the magnetic field of MRI RF coils was proposed and tested. The setup consisted of a specially configured 3D-printer, a network analyzer and a mid-performance desktop PC. The setup ... -
van der Waals interactions govern C-β-D-glucopyranosyl triazoles’ nM inhibitory potency in human liver glycogen phosphorylase
(2017)3-(C-Glucopyranosyl)-5aryl-1,2,4-triazoles with an aryl moiety larger than phenyl have been shown to have strong inhibitory potency (Ki values in the range of upper nM) for human liver glycogen phosphorylase (hlGP), a ...