Πλοήγηση ανά Θέμα "ASSOCIATION"
Αποτελέσματα 41-60 από 114
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Genetic factors influencing outcome from neurotrauma
(2012)Purpose of review Clinical outcome after neurotrauma is considerably variable and can only partly be explained by known prognostic factors. There is converging evidence from genetic research that a number of genetic variants ... -
Genetic polymorphisms in the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene and prostate cancer risk in Caucasian men
(2010)Background: Catechol-estrogen metabolites can induce carcinogenesis by acting as endogenous tumor initiators. Glucuronidation, mediated by the UDP-glucuronosyltransferase 1A1 (UGT1A1) enzyme, is a main metabolic pathway ... -
Genetic Polymorphisms in the UGT1A1 gene and breast cancer risk in Greek women
(2007)Uridine diphospho-glucuronosyltransferase 1 (UGT1A1) is involved in estradiol glucuronidation, which may play a central role in the etiology of breast cancer. A common insertion/ deletion polymorphism in the TATAA-box of ... -
Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis
(2008)Objective. Given the recent characterization of ADAMTS-5 as the main aggrecanase of cartilage destruction in mouse models, we explored whether genetic variation and, in particular, putative damaging polymorphisms in the ... -
Genetics of restless legs syndrome (RLS): State-of-the-art and future directions
(2007)Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no ... -
Glutathione S-Transferase M1 and T1 Genes and Susceptibility to Chronic Myeloid Leukemia: A Meta-Analysis
(2009)Variants of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) genes have been implicated as risk factors for chronic myeloid leukemia (CML). However, the genetic association studies that examined the relation between the ... -
A heterogeneity-based genome search meta-analysis for autism-spectrum disorders
(2006)Autism and autism-spectrum disorders exhibit high heritability, although specific susceptibility genes still remain largely elusive. We performed a heterogeneity-based genome search meta-analysis (HEGESMA) of nine genome ... -
Heterogeneity-based genome search meta-analysis for preeclampsia
(2006)Preeclampsia is a pregnancy-related disorder that causes maternal and fetal morbidity and mortality. Its exact inheritance pattern is still unknown, and genome searches for identifying susceptibility loci for preeclampsia ... -
Identification of chromosomal regions linked to premature myocardial infarction: a meta-analysis of whole-genome searches
(2006)Myocardial infarction (MI) is a complication of coronary artery disease and the leading cause of death in the Western world. MI is considered a distinct phenotype with an increased genetic component for its premature type. ... -
IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury
(2005)Objective: To investigate the association of (variable number tandem repeat) interleukin (IL) 1RN and (-511) IL-1B gene polymorphisms with brain hemorrhagic events after traumatic brain injury (TBI). Methods: Data from ... -
Impact of intraoperative hypotension on hospital stay in major abdominal surgery
(2011)Although the relationship between preoperative risk factors and outcomes has been extensively studied, the effect of intraoperative hemodynamic changes in a patient's postoperative course has been less well defined. We ... -
Impaired Expression of Genes Regulating Cholesterol Efflux in Human Osteoarthritic Chondrocytes
(2010)Altered lipid metabolism has been implicated as a critical player in osteoarthritis (OA). Our study aimed to investigate the expression of genes regulating cholesterol efflux in human chondrocytes and to study the effect ... -
Incident Atrial Fibrillation in Systemic Sclerosis: The Predictive Role of B-Type Natriuretic Peptide
(2014)Introduction: Atrial fibrillation (AF) is common in patients with systemic sclerosis (SSc) and is associated with significant morbidity, mortality, and healthcare expenditures. The aim of this study was to prospectively ... -
Increased levels of oxidative DNA damage in pesticide sprayers in Thessaly Region (Greece). Implications of pesticide exposure
(2014)The widespread use of pesticides substances nowadays largely guarantees the protection of crops and people from undesired pests. However, exposure to pesticides was related to a variety of human health effects. The present ... -
Inhibin alpha gene and susceptibility to premature ovarian failure: a data synthesis
(2009)Candidate-gene association studies that examined the association between polymorphisms of the inhibin alpha gene (G769A, C16T and A124G) and premature ovarian failure (POF) have reported contradictory results. Thus, a ... -
Interleukin-10G and interleukin-10R microsatellite polymorphisms and osteoarthritis of the knee
(2005)Objective To clarify and evaluate the possible role of interleukin-10G (IL-10G) and interleukin-10R (IL-10R) microsatellite polymorphisms of IL-10 gene in knee osteoarthritis (OA). Methods This was a case-control study. ... -
Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms in Greek multiple sclerosis (MS) patients with bout-onset MS
(2010)We investigated the association of specific polymorphisms of the interleukin IL-1b (AvaI -511 and TaqI +3,953) and IL-1 receptor antagonist (IL-1RN) (a variable number of tandem repeats; VNTR) genes with both the susceptibility ... -
The interplay between environmental and genetic factors in Parkinson's disease susceptibility: The evidence for pesticides
(2013)Parkinson's disease (PD) is a common neurodegenerative disorder characterized by dopaminergic neuron loss in the substantia nigra. Several genetic and environmental factors have been implicated in the pathogenesis of PD. ... -
Inverted BMI rather than BMI is a better proxy for percentage of body fat
(2011)Background: Percentage of body fat (BF%) is a known risk factor for a range of healthcare problems but is difficult to measure. An easy to measure proxy is the weight/height(2) ratio known as the Body Mass Index (BMI ...