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Πλοήγηση ανά Συγγραφέα "Hadjigeorgiou, G. M."

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    • The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations 

      Scholz, S. W.; Xiromerisiou, G.; Fung, H. C.; Eerola, J.; Hellstrom, O.; Papadimitriou, A.; Hadjigeorgiou, G. M.; Tienari, P. J.; Fernandez, H. H.; Mandel, R.; Okun, M. S.; Gwinn-Hardy, K.; Singleton, A. B. (2006)
      Coexistence of prion disease and idiopathic Parkinson's disease (TPD) has been previously described. It remains unclear whether this relationship may reflect the high incidence of IPD or whether both prion and IPD share ...

    • IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury 

      Hadjigeorgiou, G. M.; Paterakis, K.; Dardiotis, E.; Dardioti, M.; Aggelakis, K.; Tasiou, A.; Xiromerisiou, G.; Komnos, A.; Zintzaras, E.; Scarmeas, N.; Papadimitriou, A.; Karantanas, A. (2005)
      Objective: To investigate the association of (variable number tandem repeat) interleukin (IL) 1RN and (-511) IL-1B gene polymorphisms with brain hemorrhagic events after traumatic brain injury (TBI). Methods: Data from ...

    • Independent and joint effects of the MAPT and SNCA genes in Parkinson disease 

      Elbaz, A.; Ross, O. A.; Ioannidis, J. P. A.; Soto-Ortolaza, A. I.; Moisan, F.; Aasly, J.; Annesi, G.; Bozi, M.; Brighina, L.; Chartier-Harlin, M. C.; Destée, A.; Ferrarese, C.; Ferraris, A.; Gibson, J. M.; Gispert, S.; Hadjigeorgiou, G. M.; Jasinska-Myga, B.; Klein, C.; Krüger, R.; Lambert, J. C.; Lohmann, K.; Van De Loo, S.; Loriot, M. A.; Lynch, T.; Mellick, G. D.; Mutez, E.; Nilsson, C.; Opala, G.; Puschmann, A.; Quattrone, A.; Sharma, M.; Silburn, P. A.; Stefanis, L.; Uitti, R. J.; Valente, E. M.; Vilariño-Güell, C.; Wirdefeldt, K.; Wszolek, Z. K.; Xiromerisiou, G.; Maraganore, D. M.; Farrer, M. J. (2011)
      Objective: We studied the independent and joint effects of the genes encoding alpha-synuclein (SNCA) and microtubule-associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta-analysis of individual ...

    • Interleukin 1a (-889) gene polymorphism and primary intracerebral hemorrhage 

      Dardiotis, E.; Dardioti, M.; Komnos, A.; Paterakis, K.; Tasiou, A.; Aggelakis, K.; Xiromerisiou, G.; Gabranis, J.; Papadimitriou, A.; Hadjigeorgiou, G. M. (2007)

    • Interleukin 2 (-384) gene polymorphism and traumatic brain injury 

      Dardioti, M.; Dardiotis, E.; Aggelakis, K.; Komnos, A.; Tasiou, A.; Paterakis, K.; Noulas, G.; Papadimitriou, A.; Hadjigeorgiou, G. M. (2006)

    • The interplay between environmental and genetic factors in Parkinson's disease susceptibility: The evidence for pesticides 

      Dardiotis, E.; Xiromerisiou, G.; Hadjichristodoulou, C.; Tsatsakis, A. M.; Wilks, M. F.; Hadjigeorgiou, G. M. (2013)
      Parkinson's disease (PD) is a common neurodegenerative disorder characterized by dopaminergic neuron loss in the substantia nigra. Several genetic and environmental factors have been implicated in the pathogenesis of PD. ...

    • Intradialytic aerobic exercise training ameliorates symptoms of restless legs syndrome and improves functional capacity in patients on hemodialysis 

      Sakkas, G. K.; Hadjigeorgiou, G. M.; Karatzaferi, C.; Maridaki, M. D.; Giannaki, C. D.; Mertens, P. R.; Rountas, C.; Vlychou, M.; Liakopoulos, V.; Stefanidis, I. (2008)
      We present the first study on the influence of exercise training on restless legs syndrome (RILS) in patients on hemodialysis (HD). Restless legs syndrome has been treated pharmacologically with satisfactory results; ...

    • Investigation of Unmedicated Early Onset Restless Legs Syndrome by Voxel-Based Morphometry, T2 Relaxometry, and Functional MR Imaging during the Night-Time Hours 

      Margariti, P. N.; Astrakas, L. G.; Tsouli, S. G.; Hadjigeorgiou, G. M.; Konitsiotis, S.; Argyropoulou, M. I. (2012)
      BACKGROUND AND PURPOSE: The pathophysiology of eRLS has not yet been elucidated. The purpose of the study was to assess, in patients with eRLS, the volume, iron content, and activation of the brain during night-time episodes ...

    • Lack of Association of the UCHL-1 Gene with Parkinson's Disease in a Greek Cohort: A Haplotype-Tagging Approach 

      Xiromerisiou, G.; Kyratzi, E.; Dardiotis, E.; Bozi, M.; Tsimourtou, V.; Stamboulis, E.; Ralli, S.; Vassilatis, D.; Gourbali, V.; Kountra, P. M.; Fountas, K.; Papadimitriou, A.; Stefanis, L.; Hadjigeorgiou, G. M. (2011)

    • Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients 

      Clarimon, J.; Xiromerisiou, G.; Eerola, J.; Gourbali, V.; Hellstrom, O.; Dardiotis, E.; Peuralinna, T.; Papadimitriou, A.; Hadjigeorgiou, G. M.; Tienari, P. J.; Singleton, A. B. (2005)
      Background: Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic ...

    • Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study 

      Elbaz, A.; Nelson, L. M.; Payami, H.; Ioannidis, J. P.; Fiske, B. K.; Annesi, G.; Carmine Belin, A.; Factor, S. A.; Ferrarese, C.; Hadjigeorgiou, G. M.; Higgins, D. S.; Kawakami, H.; Krüger, R.; Marder, K. S.; Mayeux, R. P.; Mellick, G. D.; Nutt, J. G.; Ritz, B.; Samii, A.; Tanner, C. M.; Van Broeckhoven, C.; Van Den Eeden, S. K.; Wirdefeldt, K.; Zabetian, C. P.; Dehem, M.; Montimurro, J. S.; Southwick, A.; Myers, R. M.; Trikalinos, T. A. (2006)
      Background: A genome-wide association study identified 13 single-nucleotide polymorphisms (SNPs) significantly associated with Parkinson's disease. Small-scale replication studies were largely non-confirmatory, but a ...

    • A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease 

      Krüger, R.; Sharma, M.; Riess, O.; Gasser, T.; Van Broeckhoven, C.; Theuns, J.; Aasly, J.; Annesi, G.; Bentivoglio, A. R.; Brice, A.; Djarmati, A.; Elbaz, A.; Farrer, M.; Ferrarese, C.; Gibson, J. M.; Hadjigeorgiou, G. M.; Hattori, N.; Ioannidis, J. P. A.; Jasinska-Myga, B.; Klein, C.; Lambert, J. C.; Lesage, S.; Lin, J. J.; Lynch, T.; Mellick, G. D.; de Nigris, F.; Opala, G.; Prigione, A.; Quattrone, A.; Ross, O. A.; Satake, W.; Silburn, P. A.; Tan, E. K.; Toda, T.; Tomiyama, H.; Wirdefeldt, K.; Wszolek, Z.; Xiromerisiou, G.; Maraganore, D. M. (2011)
      High-profile studies have provided conflicting results regarding the involvement of the Omi/HtrA2 gene in Parkinson's disease (PD) susceptibility. Therefore, we performed a large-scale analysis of the association of common ...

    • Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease 

      Nalls, M. A.; Pankratz, N.; Lill, C. M.; Do, C. B.; Hernandez, D. G.; Saad, M.; DeStefano, A. L.; Kara, E.; Bras, J.; Sharma, M.; Schulte, C.; Keller, M. F.; Arepalli, S.; Letson, C.; Edsall, C.; Stefansson, H.; Liu, X.; Pliner, H.; Lee, J. H.; Cheng, R.; Ikram, M. A.; Ioannidis, J. P. A.; Hadjigeorgiou, G. M.; Bis, J. C.; Martinez, M.; Perlmutter, J. S.; Goate, A.; Marder, K.; Fiske, B.; Sutherland, M.; Xiromerisiou, G.; Myers, R. H.; Clark, L. N.; Stefansson, K.; Hardy, J. A.; Heutink, P.; Chen, H.; Wood, N. W.; Houlden, H.; Payami, H.; Brice, A.; Scott, W. K.; Gasser, T.; Bertram, L.; Eriksson, N.; Foroud, T.; Singleton, A. B.; Ipdg; Parkins, G. Parkinson's Study Grp PSG; AndMe; GenePd; Ngrc; Hihg; Ashkenazi Jewish Dataset, Investiga; Charge; Nabec; Ukbec; Greek Parkinson's Dis, Consortium; Alzheimer Genetic Analysis, Gr (2014)
      We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide ...

    • Large-scale replication and heterogeneity in Parkinson disease genetic loci 

      Sharma, M.; Ioannidis, J. P. A.; Aasly, J. O.; Annesi, G.; Brice, A.; Van Broeckhoven, C.; Bertram, L.; Bozi, M.; Crosiers, D.; Clarke, C.; Facheris, M.; Farrer, M.; Garraux, G.; Gispert, S.; Auburger, G.; Vilariño-Güell, C.; Hadjigeorgiou, G. M.; Hicks, A. A.; Hattori, N.; Jeon, B.; Lesage, S.; Lill, C. M.; Lin, J. J.; Lynch, T.; Lichtner, P.; Lang, A. E.; Mok, V.; Jasinska-Myga, B.; Mellick, G. D.; Morrison, K. E.; Opala, G.; Pramstaller, P. P.; Pichler, I.; Park, S. S.; Quattrone, A.; Rogaeva, E.; Ross, O. A.; Stefanis, L.; Stockton, J. D.; Satake, W.; Silburn, P. A.; Theuns, J.; Tan, E. K.; Toda, T.; Tomiyama, H.; Uitti, R. J.; Wirdefeldt, K.; Wszolek, Z.; Xiromerisiou, G.; Yueh, K. C.; Zhao, Y.; Gasser, T.; Maraganore, D.; Krüger, R. (2012)
      Objective: Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which ...

    • Low RLS prevalence and awareness in central Greece: an epidemiological survey 

      Hadjigeorgiou, G. M.; Stefanidis, I.; Dardiotis, E.; Aggellakis, K.; Sakkas, G. K.; Xiromerisiou, G.; Konitsiotis, S.; Paterakis, K.; Poultsidi, A.; Tsimourtou, V.; Ralli, S.; Gourgoulianis, K.; Zintzaras, E. (2007)
      Restless legs syndrome (RLS) is a sensorimotor disorder with a general population prevalence of 3-10%. A single, previous epidemiological study performed in southeast Europe reported the lowest prevalence rate amongst ...

    • MEIS1 and BTBD9: Genetic association with restless leg syndrome in end stage renal disease 

      Schormair, B.; Plag, J.; Kaffe, M.; Groß, N.; Czamara, D.; Samtleben, W.; Lichtner, P.; Ströhle, A.; Stefanidis, I.; Vainas, A.; Dardiotis, E.; Sakkas, G. K.; Gieger, C.; Müller-Myhsok, B.; Meitinger, T.; Heemann, U.; Hadjigeorgiou, G. M.; Oexle, K.; Winkelmann, J. (2011)
      Background: Restless legs syndrome (RLS) is a sleep related movement disorder that occurs both in an idiopathic form and in symptomatic varieties. RLS is a frequent and distressing comorbidity in end stage renal disease ...

    • Mitochondrial neurogastrointestinal encephalomyopathy: An autosomal recessive disorder due to thymidine phosphorylase mutations 

      Nishino, I.; Spinazzola, A.; Papadimitriou, A.; Hammans, S.; Steiner, I.; Hahn, C. D.; Connolly, A. M.; Verloes, A.; Guimaraes, J.; Maillard, I.; Hamano, H.; Donati, M. A.; Semrad, C. E.; Russell, J. A.; Andreu, A. L.; Hadjigeorgiou, G. M.; Vu, T. H.; Tadesse, S.; Nygaard, T. G.; Nonaka, I.; Hirano, I.; Bonilla, E.; Rowland, L. P.; DiMauro, S.; Hirano, M. (2000)
      Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder defined clinically by severe gastrointestinal dysmotility; cachexia; ptosis, ophthalmoparesis, or both; peripheral neuropathy; ...

    • Molecular genetic study of myophosphorylase deficiency (McArdle's disease) in two Yemenite-Jewish families 

      Hadjigeorgiou, G. M.; Sadeh, M.; Musumeci, O.; Dabby, R.; De Girolami, L.; Naini, A.; Papadimitriou, A.; Shanske, S.; DiMauro, S. (2002)
      Using direct sequencing and restriction fragment length polymorphism analysis, we identified two novel mutations in two unrelated Yemenite-Jewish families with typical symptoms of McArdle's disease. In one family, both ...

    • Motor signs during the course of Alzheimer disease 

      Scarmeas, N.; Hadjigeorgiou, G. M.; Papadimitriou, A.; Dubois, B.; Sarazin, M.; Brandt, J.; Albert, M.; Marder, K.; Bell, K.; Honig, L. S.; Wegesin, D.; Stern, Y. (2004)
      Background: Motor signs (MOSIs) are common in Alzheimer disease (AD) and may be associated with rates of cognitive decline, mortality, and cost of care. Objective: To describe the progression and identify predictors of ...

    • A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants 

      Sharma, M.; Ioannidis, J. P. A.; Aasly, J. O.; Annesi, G.; Brice, A.; Bertram, L.; Bozi, M.; Barcikowska, M.; Crosiers, D.; Clarke, C. E.; Facheris, M. F.; Farrer, M.; Garraux, G.; Gispert, S.; Auburger, G.; Vilarino-Guell, C.; Hadjigeorgiou, G. M.; Hicks, A. A.; Hattori, N.; Jeon, B. S.; Jamrozik, Z.; Krygowska-Wajs, A.; Lesage, S.; Lill, C. M.; Lin, J. J.; Lynch, T.; Lichtner, P.; Lang, A. E.; Libioulle, C.; Murata, M.; Mok, V.; Jasinska-Myga, B.; Mellick, G. D.; Morrison, K. E.; Meitnger, T.; Zimprich, A.; Opala, G.; Pramstaller, P. P.; Pichler, I.; Park, S. S.; Quattrone, A.; Rogaeva, E.; Ross, O. A.; Stefanis, L.; Stockton, J. D.; Satake, W.; Silburn, P. A.; Strom, T. M.; Theuns, J.; Tan, E. K.; Toda, T.; Tomiyama, H.; Uitti, R. J.; Van Broeckhoven, C.; Wirdefeldt, K.; Wszolek, Z.; Xiromerisiou, G.; Yomono, H. S.; Yueh, K. C.; Zhao, Y.; Gasser, T.; Maraganore, D.; Kruger, R.; Consortium, Geopd (2012)
      Background Two recent studies identified a mutation (p.Asp620Asn) in the vacuolar protein sorting 35 gene as a cause for an autosomal dominant form of Parkinson disease. Although additional missense variants were described, ...