• The effects of old, new and emerging medicines on metabolic aberrations in PCOS 

      Bargiota, A.; Diamanti-Kandarakis, E. (2012)
      Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age that is associated with significant adverse short- and long-term health consequences. Multiple metabolic aberrations, such as ...
    • Efficacy of Mannan-Oligosaccharides as Alternatives to Commonly Used Antibiotic Growth Promoters in Broilers 

      Kamran Z., Ali S., Ahmad S., Sohail M.U., Koutoulis K.C., Lashari M.H., Shahzad M.I., Chaudhry H.R. (2021)
      The present study was conducted to evaluate the efficacy of mannan oligosaccharides (MOS) as alternatives to antibiotic growth promoters (AGP) in broiler diets. Two hundred day-old Hubbard broiler chicks were randomly ...
    • Exercise intervention on cardiorespiratory fitness in rheumatoid arthritis patients with high cardiovascular disease risk: a single-arm pilot study 

      Sobejana M., van den Hoek J., Metsios G.S., Kitas G.D., van der Leeden M., Verberne S., Jorstad H.T., Pijnappels M., Lems W.F., Nurmohamed M.T., van der Esch M. (2022)
      Objective: In patients with rheumatoid arthritis (RA) with cardiovascular disease risk, it is unknown whether exercises are safe, improve cardiorespiratory fitness and reduce disease-related symptoms and cardiovascular-disease ...
    • Expression of AGPAT2, an enzyme involved in the glycerophospholipid/triacylglycerol biosynthesis pathway, is directly regulated by HIF-1 and promotes survival and etoposide resistance of cancer cells under hypoxia 

      Triantafyllou E.-A., Georgatsou E., Mylonis I., Simos G., Paraskeva E. (2018)
      Hypoxia inducible factor-1 (HIF-1) supports survival of normal cells under low oxygen concentration and cancer cells in the hypoxic tumor microenvironment. This involves metabolic reprogramming via upregulation of glycolysis, ...
    • Fasting-mediated metabolic and toxicity reprogramming impacts circulating microRNA levels in humans 

      Ravanidis S., Grundler F., de Toledo F.W., Dimitriou E., Tekos F., Skaperda Z., Kouretas D., Doxakis E. (2021)
      It is well-established that long-term fasting improves metabolic health, enhances the total antioxidant capacity and increases well-being. MicroRNAs oversee energy homeostasis and metabolic processes and are widely used ...
    • Genetic sharing with cardiovascular disease risk factors and diabetes reveals novel bone mineral density loci 

      Reppe S., Wang Y., Thompson W.K., McEvoy L.K., Schork A.J., Zuber V., LeBlanc M., Bettella F., Mills I.G., Desikan R.S., Djurovic S., Gautvik K.M., Dale A.M., Andreassen O.A., Estrada K., Styrkarsdottir U., Evangelou E., Hsu Y.-H., Duncan E.L., Ntzani E.E., Oei L., Albagha O.M.E., Amin N., Kemp J.P., Koller D.L., Li G., Liu C.-T., Minster R.L., Moayyeri A., Vandenput L., Willner D., Xiao S.-M., Yerges-Armstrong L.M., Zheng H.-F., Alonso N., Eriksson J., Kammerer C.M., Kaptoge S.K., Leo P.J., Thorleifsson G., Wilson S.G., Wilson J.F., Aalto V., Alen M., Aragaki A.K., Aspelund T., Center J.R., Dailiana Z., Duggan D.J., Garcia M., Garcia-Giralt N., Giroux S., Hallmans G., Hocking L.J., Husted L.B., Jameson K.A., Khusainova R., Kim G.S., Kooperberg C., Koromila T., Kruk M., Laaksonen M., Lacroix A.Z., Lee S.H., Leung P.C., Lewis J.R., Masi L., Mencej-Bedrac S., Nguyen T.V., Nogues X., Patel M.S., Prezelj J., Rose L.M., Scollen S., Siggeirsdottir K., Smith A.V., Svensson O., Trompet S., Trummer O., Van Schoor N.M., Woo J., Zhu K., Balcells S., Brandi M.L., Buckley B.M., Cheng S., Christiansen C., Cooper C., Dedoussis G., Ford I., Frost M., Goltzman D., González-Macías J., Kähönen M., Karlsson M., Khusnutdinova E., Koh J.-M., Kollia P., Langdahl B.L., Leslie W.D., Lips P., Ljunggren Ö., Lorenc R.S., Marc J., Mellström D., Obermayer-Pietsch B., Olmos J.M., Pettersson-Kymmer U., Reid D.M., Riancho J.A., Ridker P.M., Rousseau F., Slagboom P.E., Tang N.L.S., Urreizti R., Van Hul W., Viikari J., Zarrabeitia M.T., Aulchenko Y.S., Castano-Betancourt M., Grundberg E., Herrera L., Ingvarsson T., Johannsdottir H., Kwan T., Li R., Luben R., Medina-Gómez C., Palsson S.Th., Rotter J.I., Sigurdsson G., Van Meurs J.B.J., Verlaan D., Williams F.M.K., Wood A.R., Zhou Y., Pastinen T., Raychaudhuri S., Cauley J.A., Chasman D.I., Clark G.R., Cummings S.R., Danoy P., Dennison E.M., Eastell R., Eisman J.A., Gudnason V., Hofman A., Jackson R.D., Jones G., Jukema J.W., Khaw K.-T., Lehtimäki T., Liu Y., Lorentzon M., McCloskey E., Mitchell B.D., Nandakumar K., Nicholson G.C., Oostra B.A., Peacock M., Pols H.A.P., Prince R.L., Raitakari O., Reid I.R., Robbins J., Sambrook P.N., Sham P.C., Shuldiner A.R., Tylavsky F.A., Van Duijn C.M., Wareham N.J., Cupples L.A., Econs M.J., Evans D.M., Harris T.B., Kung A.W.C., Psaty B.M., Reeve J., Spector T.D., Streeten E.A., Zillikens M.C., Thorsteinsdottir U., Ohlsson C., Karasik D., Richards J.B., Brown M.A., Stefansson K., Uitterlinden A.G., Ralston S.H., Ioannidis J.P.A., Kiel D.P., Rivadeneira F., GEFOS Consortium (2015)
      Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, ...
    • Hypoxia-inducible factors and the regulation of lipid metabolism 

      Mylonis I., Simos G., Paraskeva E. (2019)
      Oxygen deprivation or hypoxia characterizes a number of serious pathological conditions and elicits a number of adaptive changes that are mainly mediated at the transcriptional level by the family of hypoxia-inducible ...
    • Impact of Bariatric Surgery on Metabolic and Gut Microbiota Profile: a Systematic Review and Meta-analysis 

      Magouliotis D.E., Tasiopoulou V.S., Sioka E., Chatedaki C., Zacharoulis D. (2017)
      We aim to review the available literature on obese patients treated with bariatric procedures, in order to assess their effect on the metabolic and gut microbiota profiles. A systematic literature search was performed in ...
    • Impact of flavonols on cardiometabolic biomarkers: A meta-analysis of randomized controlled human trials to explore the role of inter-individual variability 

      Menezes R., Rodriguez-Mateos A., Kaltsatou A., González-Sarrías A., Greyling A., Giannaki C., Andres-Lacueva C., Milenkovic D., Gibney E.R., Dumont J., Schär M., Garcia-Aloy M., Palma-Duran S.A., Ruskovska T., Maksimova V., Combet E., Pinto P. (2017)
      Several epidemiological studies have linked flavonols with decreased risk of cardiovascular disease (CVD). However, some heterogeneity in the individual physiological responses to the consumption of these compounds has ...
    • Increased cholestatic enzymes in two patients with long-term history of ulcerative colitis: Consider primary biliary cholangitis not always primary sclerosing cholangitis 

      Polychronopoulou E., Lygoura V., Gatselis N.K., Dalekos G.N. (2017)
      Several hepatobiliary disorders have been reported in ulcerative colitis (UC) patients with primary sclerosing cholangitis (PSC) being the most specific. Primary biliary cholangitis (PBC), previously known as primary biliary ...
    • Increased risk of non-alcoholic fatty liver disease in women with gestational diabetes mellitus: A population-based cohort study, systematic review and meta-analysis 

      Lavrentaki A., Thomas T., Subramanian A., Valsamakis G., Thomas N., Toulis K.A., Wang J., Daly B., Saravanan P., Sumilo D., Mastorakos G., Tahrani A.A., Nirantharakumar K. (2019)
      Aims: Non-Alcoholic Fatty Liver Disease (NAFLD) is one of the leading causes of liver transplantation in the West. This study seeks to examine whether women with gestational diabetes mellitus (GDM) are at increased risk ...
    • Innovative Use of Olive, Winery and Cheese Waste By-Products as Functional Ingredients in Broiler Nutrition 

      Bonos E., Skoufos I., Petrotos K., Giavasis I., Mitsagga C., Fotou K., Vasilopoulou K., Giannenas I., Gouva E., Tsinas A., D’alessandro A.G., Cardinali A., Tzora A. (2022)
      The purpose of this study was to evaluate the dietary use of novel silage that was created by combining three agro-industrial wastes produced in bulk, i.e., olive mill wastewater, grape pomace, and deproteinized feta cheese ...
    • Insufficient weight loss after banded vs. non-banded primary gastric bypass surgery: insights from an observational 5 year follow-up study 

      Tsai C., Dimou M., Naef M., Steffen R., Zehetner J., Nakas C.T., Bally L. (2022)
      Background: While Roux-en-Y gastric bypass (RYGB) is effective in achieving weight loss and improving obesity-related co-morbidities, insufficient weight loss in the long-term can occur. The goal was to assess whether ...
    • Interplay between oxidative damage, the redox status, and metabolic biomarkers during long-term fasting 

      Grundler F., Mesnage R., Goutzourelas N., Tekos F., Makri S., Brack M., Kouretas D., Wilhelmi de Toledo F. (2020)
      Obesity and its related metabolic disorders, as well as infectious diseases like covid-19, are important health risks nowadays. It was recently documented that long-term fasting improves metabolic health and enhanced the ...
    • Ketogenic therapy for Parkinson's disease: A systematic review and synthesis without meta-analysis of animal and human trials 

      Grammatikopoulou M.G., Tousinas G., Balodimou C., Anastasilakis D.A., Gkiouras K., Dardiotis E., Evangeliou A.E., Bogdanos D.P., Goulis D.G. (2022)
      Objective: The aim of the present systematic review was to assess the efficacy of ketogenic therapy in Parkinson's disease (PD), using all available data from randomized controlled trials (RCTs) on humans and animal studies ...
    • The laboratory diagnostic approach to thoracic and abdominal effusions in the dog, cat, and horse 

      Athanasiou L.V., Spyropoulou M., Meichner K. (2019)
      Cases involving pleural and peritoneal effusions occur relatively frequently in clinical practice. Determining the underlying etiology in these cases relies mainly on fluid analysis. The technique used for obtaining the ...
    • Leptin and exercise: An update 

      Cicchella A., Carluccio M., Scoditti E., Kaltsatou A., Massaro M. (2020)
      Leptin is a multifunctional hormone (adipocytokine) involves in several biological processes. From brain metabolism, to signalling, in sexual development, inflammation, fat metabolism, as an ergogenic aid for sport and in ...
    • Lipids and atrial fibrillation: New insights into a paradox 

      Sagris D., Harrison S.L., Lip G.Y.H. (2022)
      [No abstract available]
    • A low-protein, high-carbohydrate diet increases browning in perirenal adipose tissue but not in inguinal adipose tissue 

      Pereira M.P., Ferreira L.A.A., da Silva F.H.S., Christoffolete M.A., Metsios G.S., Chaves V.E., de França S.A., Damazo A.S., Flouris A.D., Kawashita N.H. (2017)
      Objective The aim of this study was to evaluate the browning and origin of fatty acids (FAs) in the maintenance of triacylglycerol (TG) storage and/or as fuel for thermogenesis in perirenal adipose tissue (periWAT) and ...
    • Minimal invasive technique for gene delivery in porcine liver lobe segment 

      Katsimpoulas, M.; Zacharoulis, D.; Rountas, C.; Dimitriou, C.; Mantziaras, G.; Kostomitsopoulos, N.; Habib, N.; Kostakis, A. (2011)
      Introduction: The feasibility and outcome of large volume injection of gene solution in a segment of a liver lobe, without backflow, were studied in a porcine model, using a custom-designed balloon catheter. Method: Eight ...