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    • Adrenal glands of mice and rats: A comparative morphometric study 

      Siasios A., Delis G., Tsingotjidou A., Pourlis A., Grivas I. (2022)
      Mice and rats are among the most used laboratory animals. They share numerous similarities along with differences, some yet unexplored. One of them is the morphometry of their adrenal glands, whose characteristics may be ...

    • Adverse effects of androgen deprivation therapy in patients with prostate cancer: Focus on metabolic complications 

      Tzortzis V., Samarinas M., Zachos I., Oeconomou A., Pisters L.L., Bargiota A. (2017)
      Prostate cancer is the most common cancer among men and androgen deprivation therapy (ADT) is the most effective treatment for this disease. The cornerstone of the treatment of prostate cancer is inhibition of testosterone ...

    • Adverse effects of androgen deprivation therapy in patients with prostate cancer: Focus on muscle and bone health 

      Bargiota A., Oeconomou A., Zachos I., Samarinas M., Pisters L.L., Tzortzis V. (2020)
      Androgen deprivation therapy (ADT) is the most effective systemic treatment for prostate cancer and can be succeeded either surgically or pharmaceutically. Both approaches lead to hypogonadism with a large variety of adverse ...

    • Aerobic fitness as a parameter of importance for labour loss in the heat 

      Foster J., Smallcombe J.W., Hodder S.G., Jay O., Flouris A.D., Morris N.B., Nybo L., Havenith G. (2021)
      Objectives: To derive an empirical model for the impact of aerobic fitness (maximal oxygen consumption; V̇O2max in mL∙kg−1∙min−1) on physical work capacity (PWC) in the heat. Design: Prospective, repeated measures. Methods: ...

    • Aerobic, resistance and combined training and detraining on body composition, muscle strength, lipid profile and inflammation in coronary artery disease patients 

      Theodorou A.A., Panayiotou G., Volaklis K.A., Douda H.T., Paschalis V., Nikolaidis M.G., Smilios I., Toubekis A., Kyprianou D., Papadopoulos I., Tokmakidis S.P. (2016)
      Fifty-six elderly individuals diagnosed with coronary artery disease participated in the study and were divided into four groups: an aerobic exercise group, a resistance exercise group, a combined (aerobic + resistance) ...

    • Age dependence of brachial cuff-based ambulatory PWV in end-stage kidney disease patients undergoing long-term peritoneal dialysis 

      Vaios V., Georgianos P.I., Vareta G., Divanis D., Dounousi E., Eleftheriadis T., Papagianni A., Zebekakis P.E., Liakopoulos V. (2022)
      Background: The newly introduced device Mobil-O-Graph (IEM, Stolberg, Germany) combines brachial cuff oscillometry and pulse wave analysis, enabling the determination of pulse wave velocity (PWV) via complex mathematic ...

    • Age, Body Mass Index, and Daytime and Nocturnal Hypoxia as Predictors of Hypertension in Patients With Obstructive Sleep Apnea 

      Natsios G., Pastaka C., Vavougios G., Zarogiannis S.G., Tsolaki V., Dimoulis A., Seitanidis G., Gourgoulianis K.I. (2016)
      A growing body of evidence links obstructive sleep apnea (OSA) with hypertension. The authors performed a retrospective cohort study using the University Hospital of Larissa Sleep Apnea Database (1501 patients) to determine ...

    • Age, sex, adult and larval diet shape starvation resistance in the Mediterranean fruit fly: an ecological and gerontological perspective 

      Gerofotis C.D., Kouloussis N.A., Koukougiannidou C., Papadopoulos N.T., Damos P., Koveos D.S., Carey J.R. (2019)
      The ability of an animal to withstand periods of food deprivation is a key driver of invasion success (biodiversity), adaptation to new conditions, and a crucial determinant of senescence in populations. Starvation resistance ...

    • Age- A nd sex-specific analysis of patients with embolic stroke of undetermined source 

      Ntaios G., Lip G.Y.H., Vemmos K., Koroboki E., Manios E., Vemmou A., Rodríguez-Campello A., Cuadrado-Godia E., Roquer J., Arnao V., Caso V., Paciaroni M., DIez-Tejedor E., Fuentes B., Pérez Lucas J., Arauz A., Ameriso S.F., Pertierra L., Gómez-Schneider M., Hawkes M.A., Bandini F., Chavarria Cano B., Iglesias Mohedano A.M., Garciá Pastor A., Gil-Núñez A., Putaala J., Tatlisumak T., Barboza M.A., Athanasakis G., Gioulekas F., Makaritsis K., Papavasileiou V. (2017)
      Objective: To investigate whether the correlation of age and sex with the risk of recurrence and death seen in patients with previous ischemic stroke is also evident in patients with embolic stroke of undetermined source ...

    • Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study 

      Lipnicki D.M., Crawford J.D., Dutta R., Thalamuthu A., Kochan N.A., Andrews G., Lima-Costa M.F., Castro-Costa E., Brayne C., Matthews F.E., Stephan B.C.M., Lipton R.B., Katz M.J., Ritchie K., Scali J., Ancelin M.-L., Scarmeas N., Yannakoulia M., Dardiotis E., Lam L.C.W., Wong C.H.Y., Fung A.W.T., Guaita A., Vaccaro R., Davin A., Kim K.W., Han J.W., Kim T.H., Anstey K.J., Cherbuin N., Butterworth P., Scazufca M., Kumagai S., Chen S., Narazaki K., Ng T.P., Gao Q., Reppermund S., Brodaty H., Lobo A., Lopez-Anton R., Santabárbara J., Sachdev P.S., Cohort Studies of Memory in an International Consortium (COSMIC) (2017)
      Background: The prevalence of dementia varies around the world, potentially contributed to by international differences in rates of age-related cognitive decline. Our primary goal was to investigate how rates of age-related ...

    • Age-specific and lifetime behavior patterns in Drosophila melanogaster and the Mediterranean fruit fly, Ceratitis capitata 

      Carey, J. R.; Papadopoulos, N.; Kouloussis, N.; Katsoyannos, B.; Müller, H. G.; Wang, J. L.; Tseng, Y. K. (2006)
      Patterns of behavior were recorded every 10 min during a 2-h period each day from eclosion to death for individual Drosophila melanogaster (both sexes) and Ceratitis capitata (males-only) including walking, preening, ...

    • Alcoholic liver disease and autoimmune hepatitis: Sometimes a closer look under the surface is needed 

      Rigopoulou E.I., Gatselis N., Arvaniti P., Koukoulis G.K., Dalekos G.N. (2021)
      Aims: Differential diagnosis of autoimmune hepatitis (AIH) incorporates various liver diseases, including alcoholic liver disease (ALD). We report on clinical, laboratory and outcome characteristics of AIH patients who ...

    • Aldehyde dehydrogenase 1B1: Molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme 

      Stagos, D.; Chen, Y.; Brocker, C.; Donald, E.; Jackson, B. C.; Orlicky, D. J.; Thompson, D. C.; Vasiliou, V. (2010)
      Ethanol-induced damage is largely attributed to its toxic metabolite, acetaldehyde. Clearance of acetaldehyde is achieved by its oxidation, primarily catalyzed by the mitochondrial class II aldehyde dehydrogenase (ALDH2). ...

    • Alterations in hearing function of patients with glucose disorders 

      Vergou Z., Paschou S.A., Bargiota A., Koukoulis G.N. (2019)
      Objective: To study the prevalence of hearing impairment in patients with various glucose disorders. Patients and methods: A total of 499 individuals were studied, 51 patients with type 1 (TIDM), 188 patients with type 2 ...

    • Altered activity of xenobiotic detoxifying enzymes at menopause – A cross-sectional study 

      Tsiokou V., Kilindris T., Begas E., Kouvaras E., Kouretas D., Asprodini E.K. (2020)
      Xenobiotic metabolism at menopause is an under-investigated topic, albeit women spend one-third of their life in the postmenopausal period. The present study examined the effect of menopause on the in vivo activities of ...

    • Altitude-dependent prevalence of canine granulocytic anaplasmosis in Romania 

      Matei I.A., Ionicǎ A.M., D'amico G., Corduneanu A., Daskalaki A.A., Lefkaditis M., Mihalca A.D. (2017)
      Canine granulocytic anaplasmosis (CGA) is an important tick-borne disease with worldwide distribution. The importance of this disease resides in the ability of Anaplasma phagocytophilum to infect humans and several animal ...

    • aMAP risk score predicts hepatocellular carcinoma development in patients with chronic hepatitis 

      Fan R., Papatheodoridis G., Sun J., Innes H., Toyoda H., Xie Q., Mo S., Sypsa V., Guha I.N., Kumada T., Niu J., Dalekos G., Yasuda S., Barnes E., Lian J., Suri V., Idilman R., Barclay S.T., Dou X., Berg T., Hayes P.C., Flaherty J.F., Zhou Y., Zhang Z., Buti M., Hutchinson S.J., Guo Y., Calleja J.L., Lin L., Zhao L., Chen Y., Janssen H.L.A., Zhu C., Shi L., Tang X., Gaggar A., Wei L., Jia J., Irving W.L., Johnson P.J., Lampertico P., Hou J. (2020)
      Background & Aims: Hepatocellular carcinoma (HCC) is the leading cause of death in patients with chronic hepatitis. In this international collaboration, we sought to develop a global universal HCC risk score to predict the ...

    • Amiodarone plus Ranolazine for Conversion of Post-Cardiac Surgery Atrial Fibrillation: Enhanced Effectiveness in Reduced Versus Preserved Ejection Fraction Patients 

      Simopoulos V., Hevas A., Hatziefthimiou A., Dipla K., Skoularigis I., Tsilimingas N., Aidonidis I. (2018)
      Purpose: Ranolazine (RAN) added to amiodarone (AMIO) has been shown to accelerate termination of postoperative atrial fibrillation (POAF) following coronary artery bypass surgery in patients without heart failure (HF). ...

    • Ammonius Lithotomos (3rd Century BC), the Alexandrian Innovative Surgeon Who Introduced Lithoclastic Cystotomy 

      Tsoucalas G., Sgantzos M. (2017)
      Alexandrian surgeon Ammonius Lithotomos, was the first to introduce lithoclastic cystotomy during the 3rd century BC in order to relieve a bladder's stone blockage. He had used a metallic hook or crotchet to remove the ...

    • AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders 

      Salpietro V., Dixon C.L., Guo H., Bello O.D., Vandrovcova J., Efthymiou S., Maroofian R., Heimer G., Burglen L., Valence S., Torti E., Hacke M., Rankin J., Tariq H., Colin E., Procaccio V., Striano P., Mankad K., Lieb A., Chen S., Pisani L., Bettencourt C., Männikkö R., Manole A., Brusco A., Grosso E., Ferrero G.B., Armstrong-Moron J., Gueden S., Bar-Yosef O., Tzadok M., Monaghan K.G., Santiago-Sim T., Person R.E., Cho M.T., Willaert R., Yoo Y., Chae J.-H., Quan Y., Wu H., Wang T., Bernier R.A., Xia K., Blesson A., Jain M., Motazacker M.M., Jaeger B., Schneider A.L., Boysen K., Muir A.M., Myers C.T., Gavrilova R.H., Gunderson L., Schultz-Rogers L., Klee E.W., Dyment D., Osmond M., Parellada M., Llorente C., Gonzalez-Peñas J., Carracedo A., Van Haeringen A., Ruivenkamp C., Nava C., Heron D., Nardello R., Iacomino M., Minetti C., Skabar A., Fabretto A., Hanna M.G., Bugiardini E., Hostettler I., O’Callaghan B., Khan A., Cortese A., O’Connor E., Yau W.Y., Bourinaris T., Kaiyrzhanov R., Chelban V., Madej M., Diana M.C., Vari M.S., Pedemonte M., Bruno C., Balagura G., Scala M., Fiorillo C., Nobili L., Malintan N.T., Zanetti M.N., Krishnakumar S.S., Lignani G., Jepson J.E.C., Broda P., Baldassari S., Rossi P., Fruscione F., Madia F., Traverso M., De-Marco P., Pérez-Dueñas B., Munell F., Kriouile Y., El-Khorassani M., Karashova B., Avdjieva D., Kathom H., Tincheva R., Van-Maldergem L., Nachbauer W., Boesch S., Gagliano A., Amadori E., Goraya J.S., Sultan T., Kirmani S., Ibrahim S., Jan F., Mine J., Banu S., Veggiotti P., Zuccotti G.V., Ferrari M.D., Van Den Maagdenberg A.M.J., Verrotti A., Marseglia G.L., Savasta S., Soler M.A., Scuderi C., Borgione E., Chimenz R., Gitto E., Dipasquale V., Sallemi A., Fusco M., Cuppari C., Cutrupi M.C., Ruggieri M., Cama A., Capra V., Mencacci N.E., Boles R., Gupta N., Kabra M., Papacostas S., Zamba-Papanicolaou E., Dardiotis E., Maqbool S., Rana N., Atawneh O., Lim S.Y., Shaikh F., Koutsis G., Breza M., Coviello D.A., Dauvilliers Y.A., AlKhawaja I., AlKhawaja M., Al-Mutairi F., Stojkovic T., Ferrucci V., Zollo M., Alkuraya F.S., Kinali M., Sherifa H., Benrhouma H., Turki I.B.Y., Tazir M., Obeid M., Bakhtadze S., Saadi N.W., Zaki M.S., Triki C.C., Benfenati F., Gustincich S., Kara M., Belcastro V., Specchio N., Capovilla G., Karimiani E.G., Salih A.M., Okubadejo N.U., Ojo O.O., Oshinaike O.O., Oguntunde O., Wahab K., Bello A.H., Abubakar S., Obiabo Y., Nwazor E., Ekenze O., Williams U., Iyagba A., Taiwo L., Komolafe M., Senkevich K., Shashkin C., Zharkynbekova N., Koneyev K., Manizha G., Isrofilov M., Guliyeva U., Salayev K., Khachatryan S., Rossi S., Silvestri G., Haridy N., Ramenghi L.A., Xiromerisiou G., David E., Aguennouz M., Fidani L., Spanaki C., Tucci A., Raspall-Chaure M., Chez M., Tsai A., Fassi E., Shinawi M., Constantino J.N., De Zorzi R., Fortuna S., Kok F., Keren B., Bonneau D., Choi M., Benzeev B., Zara F., Mefford H.C., Scheffer I.E., Clayton-Smith J., Macaya A., Rothman J.E., Eichler E.E., Kullmann D.M., Houlden H., SYNAPS Study Group (2019)
      AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at ...