Πλοήγηση ανά Θέμα "Chemistry, Medicinal"
Αποτελέσματα 21-40 από 58
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Ethnopharmacological approach to the herbal medicines of the "Antidotes" in Nikolaos Myrepsos' Dynameron
(2015)Ethnopharmacological relevance:This paper focuses on the plants quoted in the recipes of the first chapter entitled "About the Antidotes" belonging to the first and largest section "Element Alpha" of Nikolaos Myrepsos' ... -
Exhaled Nitric Oxide in Asthma in Adults: The End is the Beginning?
(2011)Approximately 20 years after the initial report of the measurement of exhaled nitric oxide (NO) in the exhaled air of humans, numerous publications have evaluated the possible applications of the fraction of exhaled NO ... -
Exomethylene pyranonucleosides: Efficient synthesis and biological evaluation of 1-(2,3,4-trideoxy-2-methylene-beta-D-glycero-hex-3-enopyranosyl)thymine
(2007)A new series of unsaturated pyranonucleosides with an exocyclic methylene group and thymine as heterocyclic base have been designed and synthesized. D-Galactose (1) was readily transformed in three steps into the corresponding ... -
Fluoro-ketopyranosyl nucleosides: Synthesis and biological evaluation of 3-fluoro-2-keto-beta-D-glucopyranosyl derivatives of N-4-benzoyl cytosine
(2007)1,2:5,6-Di-O-isopropylidene-ot-D-glucofuranose on mild oxidation, reduction, fluorination, and deisopropylidenation followed by acetylation gave peracetylated 3-deoxy-3-fluoro-D-glueopyranose. This was coupled with silylated ... -
Glycogen Phosphorylase as a Target for Type 2 Diabetes: Synthetic, Biochemical, Structural and Computational Evaluation of Novel N-acyl-N '-(beta-D-glucopyranosyl) Urea Inhibitors
(2015)Glycogen phosphorylase (GP), a validated target for the development of anti-hyperglycaemic agents, has been targeted for the design of novel glycopyranosylamine inhibitors. Exploiting the two most potent inhibitors from ... -
Glycosaminoglycans as Key Molecules in Atherosclerosis: The Role of Versican and Hyaluronan
(2010)Cardiovascular disease is the largest cause of death in Western societies and it primarily results from atherosclerosis of large and medium-sized vessels. Atherosclerosis leads to myocardial infarction, when it occurs in ... -
Halogen-substituted (C-beta-D-glucopyranosyl)-hydroquinone regioisomers: Synthesis, enzymatic evaluation and their binding to glycogen phosphorylase
(2011)Electrophilic halogenation of C-(2,3,4,6-tetra-O-acetyl-b-D-glucopyranosyl) 1,4-dimethoxybenzene (1) afforded regioselectively products halogenated at the para position to the D-glucosyl moiety (8, 9) that were deacetylated ... -
Influence of Potent Antioxidant Leguminosae Family Plant Extracts on Growth and Antioxidant Defense System of Hep2 Cancer Cell Line
(2010)Legumes are considered to be a very good source of polyphenolic compounds that may act as chemopreventive agents, especially by their antioxidant properties. However, many of the chemopreventive properties may depend on ... -
Inhibition of human poly(A)-specific ribonuclease (PARN) by purine nucleotides: kinetic analysis
(2009)Poly(A)-specific ribonuclease (PARN) is a cap-interacting and poly(A)-specific 3'-exoribonuclease that efficiently degrades mRNA poly(A) tails. Based on the enzyme's preference for its natural substrates, we examined the ... -
Iterative Conversion of Cyclin Binding Groove Peptides into Drug like CDK Inhibitors with Antitumor Activity
(2015)The cyclin groove is an important recognition site for substrates of the cell cycle cyclin dependent kinases and provides an opportunity for highly selective inhibition of kinase activity through a non-ATP competitive ... -
Keto and Exomethylene Pyranonucleosides as Antitumor Agents
(2012)Nucleosides and their analogues take an important place in medicinal chemistry as the structural basis for the development of therapeutic agents. Recently, there has been a renewed interest in the synthesis of keto and ... -
Matrix Metalloproteinases in Respiratory Diseases: From Pathogenesis to Potential Clinical Implications
(2009)Matrix metalloproteinases (MMPs) are zinc-endopeptidases responsible for degradation of the extracellular matrix (ECM) components including basement membrane collagen, interstitial collagen, fibronectin, and various ... -
Modulation of catalytic RNA biological activity by small molecule effectors
(2006)Catalytic RNAs, known as ribozymes, act as true enzymes and are implicated in important biological processes, such as protein synthesis, mRNA splicing, transcriptional regulation and retroviral replication. Ribozymes are ... -
Modulation of Poly(A)-specific Ribonuclease (PARN): Current Knowledge and Perspectives
(2012)Deadenylation is the exoribonucleolytic shortening of eukaryotic poly(A) tails. It is often the first and rate-limiting step for mRNA decay and translational silencing. The process is catalysed by a diversity of deadenylases, ... -
N-substituted Pyrrole-based Scaffolds as Potential Anticancer and Antiviral Lead Structures
(2015)Undoubtedly, efficient cancer treatment has been a significant challenge for the scientific community over the last decades. Despite tremendous progress made towards this direction, there are still efforts needed to discover ... -
Optimization of Non-ATP Competitive CDK/Cyclin Groove Inhibitors through REPLACE-Mediated Fragment Assembly
(2013)A major challenge in drug discovery is to develop and improve methods for targeting protein-protein interactions. Further exemplification of the REPLACE (REplacement with Partial Ligand Alternatives through Computational ... -
Quantification of the Effects of Ionic Strength, Viscosity, and Hydrophobicity on Protein-Ligand Binding Affinity
(2014)In order to quantify the interactions between molecules of biological interest, the determination of the dissociation constant (K-d) is essential. Estimation of the binding affinity in this way is routinely performed in ...