Listar por autor "Stathopoulos, C."
Mostrando ítems 21-38 de 38
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Mitochondrial tRNA mutations: Clinical and functional perturbations
Zifa, E.; Giannouli, S.; Theotokis, P.; Stamatis, C.; Mamuris, Z.; Stathopoulos, C. (2007)During the last decade, there has been a progressive accumulation of reports that connect the identification of specific mitochondrial tRNA gene mutations to severe disorders in human. As a result, mitochondrial tRNA genes ... -
Modulation of catalytic RNA biological activity by small molecule effectors
Vourekas, A.; Kalavrizioti, D.; Stathopoulos, C.; Drainas, D. (2006)Catalytic RNAs, known as ribozymes, act as true enzymes and are implicated in important biological processes, such as protein synthesis, mRNA splicing, transcriptional regulation and retroviral replication. Ribozymes are ... -
Modulation of Poly(A)-specific Ribonuclease (PARN): Current Knowledge and Perspectives
Balatsos, N. A. A.; Maragozidis, P.; Anastasakis, D.; Stathopoulos, C. (2012)Deadenylation is the exoribonucleolytic shortening of eukaryotic poly(A) tails. It is often the first and rate-limiting step for mRNA decay and translational silencing. The process is catalysed by a diversity of deadenylases, ... -
Molecular cloning and biochemical characterization of VIM-12, a novel hybrid VIM-1/VIM-2 metallo-beta-lactamase from a Klebsiella pneumoniae clinical isolate, reveal atypical substrate specificity
Kontou, M.; Pournaras, S.; Kristo, I.; Ikonomidis, A.; Maniatis, A. N.; Stathopoulos, C. (2007)Metallo-beta-lactamases (MBLs) are considered an emerging family of Zn2+-dependent enzymes that significantly contribute to the resistance of many nosocomial pathogens against beta-lactam antimicrobials. Since these ... -
Molecular cloning and biochemical characterization of VIM-12, a novel hybrid VIM-1/VIM-2 metallo-beta-lactamase from a Klebsiella pneumoniae clinical isolate, reveals atypical substrate specificity
Kontou, M.; Pournaras, S.; Kristo, I.; Ikonomidis, A.; Maniatis, A. N.; Stathopoulos, C. (2008) -
Molecular phylogeny of VP1, 2A, and 2B genes of echovirus isolates: epidemiological linkage and observations on genetic variation
Kottaridi, C.; Bolanaki, E.; Mamuris, Z.; Stathopoulos, C.; Markoulatos, P. (2006)Phylogenetic relationships between 37 echovirus clinical isolates, most of them originating from an aseptic meningitis outbreak during 2001 in Greece, were investigated by RT-PCR and sequencing. The generic primers 292 and ... -
A novel G3337A mitochondrial ND1 mutation related to cardiomyopathy co-segregates with tRNA(Leu(CUN)) A12308G and tRNA(Thr) C15946T mutations
Zifa, E.; Theotokis, P.; Kaminari, A.; Maridaki, H.; Leze, H.; Petsiava, E.; Mamuris, Z.; Stathopoulos, C. (2008)We describe a novel Mutation in human mitochondrial NADH dehydrogenase 1 gene (ND1), a G to A transition at nucleotide position 3337,which is co-segregated with two known mutations in tRNA(Leu(CUN)) A12308G and tRNA(Thr) ... -
On the role of an unusual tRNA(Gly) isoacceptor in Staphylococcus aureus
Giannouli, S.; Kyritsis, A.; Malissovas, N.; Becker, H. D.; Stathopoulos, C. (2009)In the available Staphylococcus aureus genomes, four different genes have been annotated to encode tRNA(Gly) isoacceptors. Besides their prominent role in protein synthesis, some of them also participate in the formation ... -
Recruitment of mitochondrial tRNA genes as auxiliary variability markers for both intra- and inter-species analysis: The paradigm of brown hare (Lepus europaeus)
Stamatis, C.; Giannouli, S.; Suchentrunk, F.; Sert, H.; Stathopoulos, C.; Mamuris, Z. (2008)We sequenced and analyzed the mitochondrial tRNA(Thr) and tRNA(Pro) genes from brown hare (Lepus europaeus) individuals of different geographic distribution and we investigated the role of various nucleotide substitutions ... -
The RNA component of ribonuclease P from Dictyostelium discoideum
Vourekas, A.; Stamatopoulou, V.; Stathopoulos, C.; Drainas, D. (2008) -
RNA-Mediated therapeutics: From gene inactivation to clinical application
Kalavrizioti, D.; Vourekas, A.; Stamatopoulou, V.; Toumpeki, C.; Giannouli, S.; Stathopoulos, C.; Drainas, D. (2006)The specific targeting and inactivation of gene expression represents nowdays the goal of the mainstream basic and applied biomedical research. Both researchers and pharmaceutical companies, taking advantage of the vast ... -
RNase P: A promising molecular target for the development of new drugs
Tekos, A.; Stathopoulos, C.; Tsambaos, D.; Drainas, D. (2004)RNase P is an ubiquitous and essential endonuclease in tRNA biogenesis, which generates the mature 5′-termini of tRNAs. RNase P activities have been identified in all three kingdoms of life (Bacteria, Archaea, Eukarya). ... -
A single tRNA base pair mediates bacterial tRNA-dependent biosynthesis of asparagine
Bailly, M.; Giannouli, S.; Blaise, M.; Stathopoulos, C.; Kern, D.; Becker, H. D. (2006)In many prokaryotes and in organelles asparagine and glutamine are formed by a tRNA-dependent amidotransferase (AdT) that catalyzes amidation of aspartate and glutamate, respectively, mischarged on tRNA(Asn) and tRNA(Gln). ... -
Studies on the Essential Intramolecular Interaction Between the A1 and A2 Domains of von Willebrand Factor
Karoulia, Z.; Papadopoulos, G.; Nomikos, M.; Thanassoulas, A.; Papadopoulou, T. C.; Nounesis, G.; Kontou, M.; Stathopoulos, C.; Leonidas, D. D. (2013)Haemostasis depends on the balanced participation of von Willebrand factor (vWF), a large multimeric and multidomain glycoprotein with essential role during the initial steps of blood clotting. Mature vWF circulates in ... -
Studies on the role of a pseudogene encoding an atypical tRNA(Gly) in Staphylococcus aureus
Giannouli, S.; Kyritsis, A.; Stathopoulos, C. (2008) -
Transosseous application of low-intensity ultrasound at the tendon-bone interface affects the healing rate and up-regulates simultaneously the expression of collagen type i and tRNAGly
Papatheodorou, L. K.; Grafanaki, K.; Giannouli, S.; Fotiadis, D. I.; Stathopoulos, C.; Malizos, K. N. (2008)The present study investigates the effect of transosseous low-intensity pulsed ultrasound (LiUS) during lingamentization process on the healing at tendon graft-bone interface in rabbits. Analysis of the RT-PCR products ... -
A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition, among threonyl-tRNA synthetases
Ruan, B.; Bovee, M. L.; Sacher, M.; Stathopoulos, C.; Poralla, K.; Francklyn, C. S.; Söll, D. (2005)Borrelidin, a compound with anti-microbial and anti-angiogenic properties, is a known inhibitor of bacterial and eukaryal threonyl-tRNA synthetase (ThrRS). The inhibition mechanism of borrelidin is not well understood. ... -
Wide dissemination of linezolid-resistant Staphylococcus epidermidis in Greece is associated with a linezolid-dependent ST22 clone
Karavasilis, V.; Zarkotou, O.; Panopoulou, M.; Kachrimanidou, M.; Themeli-Digalaki, K.; Stylianakis, A.; Gennimata, V.; Ntokou, E.; Stathopoulos, C.; Tsakris, A.; Pournaras, S.; Greek Study Grp Staphylococcal, Lin (2015)Objectives: Dependence on linezolid was recently described as significant growth acceleration of linezolid-resistant Staphylococcus epidermidis (LRSE) isolates upon linezolid exposure. We investigated the possible contribution ...