Πλοήγηση ανά Συγγραφέα "Hadjigeorgiou, G. M."
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Current trends in the management of uremic restless legs syndrome: A systematic review on aspects related to quality of life, cardiovascular mortality and survival
Sakkas, G. K.; Giannaki, C. D.; Karatzaferi, C.; Maridaki, M.; Koutedakis, Y.; Hadjigeorgiou, G. M.; Stefanidis, I. (2015)Restless legs syndrome (RLS) affects almost one out of three end-stage renal disease patients. This review assesses the current treatment options for uremic RLS and the potential benefits of those treatments on quality of ... -
Depressive symptoms in Alzheimer's disease: Natural course and temporal relation to function and cognitive status
Holtzer, R.; Scarmeas, N.; Wegesin, D. J.; Albert, M.; Brandt, J.; Dubois, B.; Hadjigeorgiou, G. M.; Stern, Y. (2005)OBJECTIVES: To examine the natural course of depressive symptoms in patients with probable Alzheimer's disease (AD), specifically, the temporal relationship between depressive symptoms, function, and cognitive status. ... -
Effect of angiotensin-converting enzyme tag single nucleotide polymorphisms on the outcome of patients with traumatic brain injury
Dardiotis, E.; Paterakis, K.; Siokas, V.; Tsivgoulis, G.; Dardioti, M.; Grigoriadis, S.; Simeonidou, C.; Komnos, A.; Kapsalaki, E.; Fountas, K.; Hadjigeorgiou, G. M. (2015)Background Genetic variants appear to influence, at least to some degree, the extent of brain injury and the clinical outcome of patients who have sustained a traumatic brain injury (TBI). Angiotensin-converting enzyme ... -
The Effect of Disease Modifying Therapies on Brain Atrophy in Patients with Relapsing-Remitting Multiple Sclerosis: A Systematic Review and Meta-Analysis
Tsivgoulis, G.; Katsanos, A. H.; Grigoriadis, N.; Hadjigeorgiou, G. M.; Heliopoulos, I.; Kilidireas, C.; Voumvourakis, K. (2015)Background The aim of the present meta-analysis was to evaluate the effect of disease-modifying drugs (DMD) on brain atrophy in patients with relapsing-remitting multiple sclerosis (RRMS) using available randomized-controlled ... -
Effect of exercise training and dopamine agonists in patients with uremic restless legs syndrome: a six-month randomized, partially double-blind, placebo-controlled comparative study
Giannaki, C. D.; Sakkas, G. K.; Karatzaferi, C.; Hadjigeorgiou, G. M.; Lavdas, E.; Kyriakides, T.; Koutedakis, Y.; Stefanidis, I. (2013)Background: Restless Legs Syndrome is very common in hemodialysis patients however there are no comparative studies assessing the effectiveness of a non-pharmacological treatment to a classical treatment on parameters ... -
Epidemiology, impact, and treatment options of restless legs syndrome in end-stage renal disease patients: An evidence-based review
Giannaki, C. D.; Hadjigeorgiou, G. M.; Karatzaferi, C.; Pantzaris, M. C.; Stefanidis, I.; Sakkas, G. K. (2014)Restless legs syndrome (RLS) (or Willis-Ekbom disease) is a neurological disorder with high prevalence among the end-stage renal disease population. This is one of the most predominant types of secondary RLS, and it is ... -
Evaluation of MMP1 and MMP3 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma
Tsironi, E. E.; Pefkianaki, M.; Tsezou, A.; Kotoula, M. G.; Dardiotis, E.; Almpanidou, P.; Papathanasiou, A. A.; Rodopoulou, P.; Chatzoulis, D. Z.; Hadjigeorgiou, G. M. (2009)Purpose: To investigate possible genetic associations of matrix metalloproteinase-1 (MMP1) and MMP3 gene polymorphisms with exfoliation syndrome (XFS) with (XFS/+G) and without (XFS/-G) glaucoma in a cohort of Greek patients. ... -
Evidence of an association between the scavenger receptor class B member 2 gene and Parkinson's disease
Michelakakis, H.; Xiromerisiou, G.; Dardiotis, E.; Bozi, M.; Vassilatis, D.; Kountra, P. M.; Patramani, G.; Moraitou, M.; Papadimitriou, D.; Stamboulis, E.; Stefanis, L.; Zintzaras, E.; Hadjigeorgiou, G. M. (2012)Lysosomal protein 2 (LIMP2), the product of the scavenger receptor class B member 2 (SCARB2) gene, is a ubiquitously expressed transmembrane protein that is the mannose-6-phosphateindependent receptor for glucocerebrosidase ... -
Evidence of Increased Muscle Atrophy and Impaired Quality of Life Parameters in Patients with Uremic Restless Legs Syndrome
Giannaki, C. D.; Sakkas, G. K.; Karatzaferi, C.; Hadjigeorgiou, G. M.; Lavdas, E.; Liakopoulos, V.; Tsianas, N.; Koukoulis, G. N.; Koutedakis, Y.; Stefanidis, I. (2011)Background: Restless Legs Syndrome is a very common disorder in hemodialysis patients. Restless Legs Syndrome negatively affects quality of life; however it is not clear whether this is due to mental or physical parameters ... -
Family-based association study of the loci 2 and 3 in a European restless legs syndrome population
Kemlink, D.; Polo, O.; Montagna, P.; Provini, F.; Stiasny-Kolster, K.; Oertel, W.; de Weerd, A.; Nevsimalova, S.; Sonka, K.; Hogl, B.; Frauscher, B.; Poewe, W.; Trenkwalder, C.; Pramstaller, P. P.; Ferini-Strambi, L.; Zucconi, M.; Konofal, E.; Arnulf, I.; Hadjigeorgiou, G. M.; Happe, S.; Klein, C.; Hiller, A.; Lichtner, P.; Meitinger, T.; Muller-Myshok, B.; Winkelmann, J. (2007)Three loci for the restless legs syndrome (RLS) on chromosomes 12q, 14q, and 9p (RLS 1, RLS2, and RLS3) have been mapped, but no gene has been identified as yet. RLS1 has been confirmed in families from three different ... -
Gain-of-function variant in GLUD2 glutamate dehydrogenase modifies Parkinson's disease onset
Plaitakis, A.; Latsoudis, H.; Kanavouras, K.; Ritz, B.; Bronstein, J. M.; Skoula, I.; Mastorodemos, V.; Papapetropoulos, S.; Borompokas, N.; Zaganas, I.; Xiromerisiou, G.; Hadjigeorgiou, G. M.; Spanaki, C. (2010)Parkinson's disease (PD), a common neurodegenerative disorder characterized by progressive loss of dopaminergic neurons and their terminations in the basal ganglia, is thought to be related to genetic and environmental ... -
Genetic and molecular pathogenesis of Parkinson's disease
Agorogiannis, E. I.; Agorogiannis, G. I.; Papadimitriou, A.; Hadjigeorgiou, G. M. (2006)Parkinson's disease (PD), a common progressive degenerative disease of the central nervous system, affects about 1% of adults aged older than 60 years. PD is characterized by rigidity, tremor, postural instability and ... -
Genetic assessment of familial and early-onset Parkinson's disease in a Greek population
Bozi, M.; Papadimitriou, D.; Antonellou, R.; Moraitou, M.; Maniati, M.; Vassilatis, D. K.; Papageorgiou, S. G.; Leonardos, A.; Tagaris, G.; Malamis, G.; Theofilopoulos, D.; Kamakari, S.; Stamboulis, E.; Hadjigeorgiou, G. M.; Athanassiadou, A.; Michelakakis, H.; Papadimitriou, A.; Gasser, T.; Stefanis, L. (2014)Background and purpose Although the first mutation associated with Parkinson's disease (PD) was identified several years ago in the alpha-synuclein (SNCA) gene in families of Greek and Italian ancestry, a more systematic ... -
Genetic association studies in patients with traumatic brain injury
Dardiotis, E.; Fountas, K. N.; Dardioti, M.; Xiromerisiou, G.; Kapsalaki, E.; Tasiou, A.; Hadjigeorgiou, G. M. (2010)Traumatic brain injury (TBI) constitutes a major cause of mortality and disability worldwide, especially among young individuals. It is estimated that despite all the recent advances in the management of TBI, approximately ... -
Genetic basis of Parkinson disease
Xiromerisiou, G.; Dardiotis, E.; Tsimourtou, V.; Kountra, P. M.; Paterakis, K. N.; Kapsalaki, E. Z.; Fountas, K. N.; Hadjigeorgiou, G. M. (2010)Over the past few years, considerable progress has been made in understanding the molecular mechanisms of Parkinson disease (PD). Mutations in certain genes are found to cause monogenic forms of the disorder, with autosomal ... -
Genetic factors influencing outcome from neurotrauma
Dardiotis, E.; Grigoriadis, S.; Hadjigeorgiou, G. M. (2012)Purpose of review Clinical outcome after neurotrauma is considerably variable and can only partly be explained by known prognostic factors. There is converging evidence from genetic research that a number of genetic variants ... -
Genetic susceptibility to primary intracerebral haemorrhage
Dardiotis, E.; Dardioti, M.; Xiromerisiou, G.; Paterakis, K.; Fountas, K.; Hadjigeorgiou, G. M. (2009)Primary intracerebral haemorrhage (PICH) originates from the spontaneous rupture of cerebral arteries as a result of chronic degenerative alterations. Although the aetiology of PICH has not been fully elucidated, it may ... -
Genetics of restless legs syndrome (RLS): State-of-the-art and future directions
Winkelmann, J.; Polo, O.; Provini, F.; Nevsimalova, S.; Kemlink, D.; Sonka, K.; Hogl, B.; Poewe, W.; Stiasny-Kolster, K.; Oertel, W.; de Weerd, A.; Strambi, L. F.; Zucconi, M.; Pramstaller, P. P.; Arnulf, I.; Trenkwalder, C.; Klein, C.; Hadjigeorgiou, G. M.; Happe, S.; Rye, D.; Montagna, P. (2007)Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no ... -
Haemodialysis patients with sleep apnoea syndrome experience increased central adiposity and altered muscular composition and functionality
Sakkas, G. K.; Gourgoulianis, K. I.; Karatzaferi, C.; Liakopoulos, V.; Maridaki, M. D.; Pastaka, C.; Lavdas, E.; Soher, B. J.; Dovas, S.; Fezoulidis, I.; Hadjigeorgiou, G. M.; Stefanidis, I. (2008)Background. Sleep apnoea frequently affects patients with end-stage renal disease. However, it is still unclear whether or to what extent sleep disorders may affect functional capacity and quality of life in haemodialysis ... -
The Hellenic Longitudinal Investigation of Aging and Diet (HELIAD): Rationale, Study Design, and Cohort Description
Dardiotis, E.; Kosmidis, M. H.; Yannakoulia, M.; Hadjigeorgiou, G. M.; Scarmeas, N. (2014)Background: Accumulating epidemiological evidence from several populations supports the important role of the Mediterranean-type diet (MeDi) in reducing the risk for age-related diseases such as Alzheimer's disease (AD). ...