Πλοήγηση ανά Θέμα "sequence analysis"

An Activating Janus kinase-3 mutation is associated with cytotoxic T lymphocyte antigen-4-dependent Immune dysregulation syndrome

Sic H., Speletas M., Cornacchione V., Seidl M., Beibel M., Linghu B., Yang F., Sevdali E., Germenis A.E., Oakeley E.J., Vangrevelinghe E., Sailer A.W., Traggiai E., Gram H., Eibel H. (2017)

Heterozygous mutations in the cytotoxic T lymphocyte antigen-4 (CTLA-4) are associated with lymphadenopathy, autoimmunity, immune dysregulation, and hypogammaglobulinemia in about 70% of the carriers. So far, the incomplete ...

Activation of FADD-Dependent neuronal death pathways as a predictor of pathogenicity for LRRK2 mutations

Melachroinou K., Leandrou E., Valkimadi P.-E., Memou A., Hadjigeorgiou G., Stefanis L., Rideout H.J. (2016)

Background Despite the plethora of sequence variants in LRRK2, only a few clearly segregate with PD. Even within this group of pathogenic mutations, the phenotypic profile can differ widely. Objective We examined multiple ...

AGAMEMNON: an Accurate metaGenomics And MEtatranscriptoMics quaNtificatiON analysis suite

Skoufos G., Almodaresi F., Zakeri M., Paulson J.N., Patro R., Hatzigeorgiou A.G., Vlachos I.S. (2022)

We introduce AGAMEMNON (https://github.com/ivlachos/agamemnon) for the acquisition of microbial abundances from shotgun metagenomics and metatranscriptomic samples, single-microbe sequencing experiments, or sequenced host ...

Ancestral Absence of Electron Transport Chains in Patescibacteria and DPANN

Beam J.P., Becraft E.D., Brown J.M., Schulz F., Jarett J.K., Bezuidt O., Poulton N.J., Clark K., Dunfield P.F., Ravin N.V., Spear J.R., Hedlund B.P., Kormas K.A., Sievert S.M., Elshahed M.S., Barton H.A., Stott M.B., Eisen J.A., Moser D.P., Onstott T.C., Woyke T., Stepanauskas R. (2020)

Recent discoveries suggest that the candidate superphyla Patescibacteria and DPANN constitute a large fraction of the phylogenetic diversity of Bacteria and Archaea. Their small genomes and limited coding potential have ...

Antimicrobial Agent Susceptibility and Typing of Staphylococcal Isolates from Subclinical Mastitis in Ewes

Vasileiou N.G.C., Sarrou S., Papagiannitsis C., Chatzopoulos D.C., Malli E., Mavrogianni V.S., Petinaki E., Fthenakis G.C. (2019)

Objective was to study susceptibility to antimicrobial agents of 142 staphylococcal isolates from subclinical mastitis in ewes. In total, 41.5% of these were resistant and 5.6% multidrug resistant. More coagulase-negative ...

Assessment of the effects of oxamyl on the bacterial community of an agricultural soil exhibiting enhanced biodegradation

Gallego S., Devers-Lamrani M., Rousidou K., Karpouzas D.G., Martin-Laurent F. (2019)

Modern agricultural practices largely rely on pesticides to protect crops against various pests and to ensure high yields. Following their application to crops a large amount of pesticides ends up in soil where they may ...

Association of codon 72 polymorphism of p53 with the severity of cervical dysplasia, E6-T350G and HPV16 variant lineages in HPV16-infected women

Moschonas G.D., Tsakogiannis D., Lamprou K.A., Mastora E., Dimitriou T.G., Kyriakopoulou Z., Kottaridi C., Karakitsos P., Markoulatos P. (2017)

Purpose. Polymorphic variability in the tumour-suppressor protein p53 at codon 72 has a considerable impact on cervical cancer development. The present study clarified the association between p53 codon 72 genotypes and the ...

Association of maternal Toll-like receptor-4 alleles with susceptibility to early-onset preeclampsia in central Greece

Vamvakopoulou D.N., Satra M., Fegga A., Kourti M., Sidiropoulos A., Daponte A., Gounaris A., Syrogianopoulos G., Vamvakopoulos N.C., Sotiriou S. (2019)

Introduction: Altered maternal inflammatory responses may play a role in the development of hypertensive disorders of pregnancy like preeclampsia, its more severe early-onset form and intrauterine growth restriction. We ...

Characterisation of a ST100 Staphylococcus epidermidis producing an LnuB nucleotidyltransferase: Evidence for interspecies spread of an lnuB-carrying transposon

Papagiannitsis C.C., Sarrou S., Tsilipounidaki K., Malli E., Medvecky M., Hrabak J., Fthenakis G.C., Petinaki E. (2018)

[No abstract available]

Deep Intronic SERPING1 Gene Variants: Ending One Odyssey and Starting Another?

Germenis A.E., Vatsiou S., Csuka D., Zamanakou M., Farkas H. (2021)

[No abstract available]

Detection and molecular characterization of a new genotype of infectious bursal disease virus in Portugal

Legnardi M., Franzo G., Tucciarone C.M., Koutoulis K., Duarte I., Silva M., Le Tallec B., Cecchinato M. (2022)

Infectious bursal disease virus (IBDV) is an immunosuppressive pathogen with a bi-segmented, double-stranded RNA genome. Two serotypes, named 1 and 2, are recognized, and serotype 1 is traditionally divided into classical, ...

Detection of mitochondrial transfer RNA (mt-tRNA) gene mutations in patients with idiopathic pulmonary fibrosis and sarcoidosis

Daniil Z., Kotsiou O.S., Grammatikopoulos A., Peletidou S., Gkika H., Malli F., Antoniou K., Vasarmidi E., Mamuris Z., Gourgoulianis K., Zifa E. (2018)

Mitochondrial reactive oxygen species production may lead to tissue injury associated with two respiratory disorders of unknown origin which are shared by common tissue fibrosis, IPF and sarcoidosis. Sequence analysis of ...

DIANA-LncBase v2: Indexing microRNA targets on non-coding transcripts

Paraskevopoulou M.D., Vlachos I.S., Karagkouni D., Georgakilas G., Kanellos I., Vergoulis T., Zagganas K., Tsanakas P., Floros E., Dalamagas T., Hatzigeorgiou A.G. (2016)

MicroRNAs (miRNAs) are short non-coding RNAs (ncRNAs) that act as post-transcriptional regulators of coding gene expression. Long non-coding RNAs (lncRNAs) have been recently reported to interact with miRNAs. The sponge-like ...

DIANA-LncBase v3: Indexing experimentally supported miRNA targets on non-coding transcripts

Karagkouni D., Paraskevopoulou M.D., Tastsoglou S., Skoufos G., Karavangeli A., Pierros V., Zacharopoulou E., Hatzigeorgiou A.G. (2020)

DIANA-LncBase v3.0 (www.microrna.gr/LncBase) is a reference repository with experimentally supported miRNA targets on non-coding transcripts. Its third version provides approximately half a million entries, corresponding ...

Diana-map: Analyzing mirna from raw ngs data to quantification

Alexiou A., Zisis D., Kavakiotis I., Miliotis M., Koussounadis A., Karagkouni D., Hatzigeorgiou A.G. (2021)

microRNAs (miRNAs) are small non-coding RNAs (~22 nts) that are considered central post-transcriptional regulators of gene expression and key components in many pathological conditions. Next-Generation Sequencing (NGS) ...

DIANA-mirExTra v2.0: Uncovering microRNAs and transcription factors with crucial roles in NGS expression data

Vlachos I.S., Vergoulis T., Paraskevopoulou M.D., Lykokanellos F., Georgakilas G., Georgiou P., Chatzopoulos S., Karagkouni D., Christodoulou F., Dalamagas T., Hatzigeorgiou A.G. (2016)

Differential expression analysis (DEA) is one of the main instruments utilized for revealing molecular mechanisms in pathological and physiological conditions. DIANA-mirExTra v2.0 (http://www.microrna. gr/mirextrav2) ...

DIANA-TarBase v8: A decade-long collection of experimentally supported miRNA-gene interactions

Karagkouni D., Paraskevopoulou M.D., Chatzopoulos S., Vlachos I.S., Tastsoglou S., Kanellos I., Papadimitriou D., Kavakiotis I., Maniou S., Skoufos G., Vergoulis T., Dalamagas T., Hatzigeorgiou A.G. (2018)

DIANA-TarBase v8 (http://www.microrna.gr/tarbase) is a reference database devoted to the indexing of experimentally supported microRNA (miRNA) targets. Its eighth version is the first database indexing >1 million entries, ...

Emergence of sequence type 11 Klebsiella pneumoniae coproducing NDM-1 and VIM-1 metallo-β-lactamases in a Greek hospital

Papagiannitsis C.C., Malli E., Florou Z., Sarrou S., Hrabak J., Mantzarlis K., Zakynthinos E., Petinaki E. (2017)

Sequence type 11 Klebsiella pneumoniae, coproducing NDM-1 and VIM-1 metallo-β-lactamases, were isolated in a Greek hospital. blaNDM-1 was part of a Tn125 derivative, located on an ~90-kb plasmid similar to the NDM-1-encoding ...

Emm Types and clusters and macrolide resistance of pediatric group A streptococcal isolates in Central Greece during 2011-2017

Grivea I.N., Syrogiannopoulos G.A., Michoula A.N., Gazeti G., Malli E., Tsilipounidaki K., Fouzas S., Anthracopoulos M.B., Petinaki E. (2020)

Background The surveillance of emm types and macrolide susceptibility of group A streptococcus (GAS) in various areas and time periods enhances the understanding of the epidemiology of GAS infections and may guide treatment ...

ESBL-Producing Moellerella wisconsensis—The Contribution of Wild Birds in the Dissemination of a Zoonotic Pathogen

Athanasakopoulou Z., Sofia M., Giannakopoulos A., Papageorgiou K., Chatzopoulos D.C., Spyrou V., Petridou E., Petinaki E., Billinis C. (2022)

Moellerella wisconsensis is an Enterobacteriaceae with unclarified dispersion and pathogenic-ity. During an ongoing investigation about antimicrobial resistance in Greece, the occurrence of M. wisconsensis was evaluated ...