Πλοήγηση ανά Θέμα "nucleotide sequence"

4-Arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects

Kryštof, V.; Cankař, P.; Fryšová, I.; Slouka, J.; Kontopidis, G.; Džubák, P.; Hajdúch, M.; Srovnal, J.; De Azevedo Jr, W. F.; Orság, M.; Paprskářová, M.; Rolčík, J.; Látr, A.; Fischer, P. M.; Strnad, M. (2006)

In a routine screening of our small-molecule compound collection we recently identified 4-arylazo-3,5-diamino-1H-pyrazoles as a novel group of ATP antagonists with moderate potency against CDK2-cyclin E. A preliminary SAR ...

The 5′ regulatory region of the human fetal globin genes is a gene conversion hotspot

Kalamaras, A.; Chassanidis, C.; Samara, M.; Chiotoglou, I.; Vamvakopoulos, N. K.; Papadakis, M. N.; Kollia, P.; Patrinos, G. P. (2008)

The human fetal globin genes consist of the first mammalian genomic loci for which gene conversion was reported. To date, 14 gene conversions have been described in the human Gγ- and Aγ-globin genes, the vast majority of ...

Aldehyde dehydrogenase 1B1: Molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme

Stagos, D.; Chen, Y.; Brocker, C.; Donald, E.; Jackson, B. C.; Orlicky, D. J.; Thompson, D. C.; Vasiliou, V. (2010)

Ethanol-induced damage is largely attributed to its toxic metabolite, acetaldehyde. Clearance of acetaldehyde is achieved by its oxidation, primarily catalyzed by the mitochondrial class II aldehyde dehydrogenase (ALDH2). ...

Anguillicola (Anguillicoides) crassus: Morphometric characteristics and pathogenicity in eels (Anguilla anguilla) in Greece

Kantzoura V., Sapounidis A., Kouam M.K., Kolygas M.Ν., Krey G., Koutrakis E. (2021)

Anguillicola (Anguillicoides) crassus is a swimbladder nematode parasite of Anguilla anguilla (Linnaeus, 1758). The present study investigates the morphology and pathogenicity of A. crassus in European eel, as well as, the ...

Antimicrobial Agent Susceptibility and Typing of Staphylococcal Isolates from Subclinical Mastitis in Ewes

Vasileiou N.G.C., Sarrou S., Papagiannitsis C., Chatzopoulos D.C., Malli E., Mavrogianni V.S., Petinaki E., Fthenakis G.C. (2019)

Objective was to study susceptibility to antimicrobial agents of 142 staphylococcal isolates from subclinical mastitis in ewes. In total, 41.5% of these were resistant and 5.6% multidrug resistant. More coagulase-negative ...

Association of α-synuclein Rep1 polymorphism and Parkinson's disease: Influence of Rep1 on age at onset

Hadjigeorgiou, G. H.; Xiromerisiou, G.; Gourbali, V.; Aggelakis, K.; Scarmeas, N.; Papadimitriou, A.; Singleton, A. (2006)

The α-synuclein Rep1 polymorphism was studied in patients and controls in an ethnic Greek population. There was an association of allele 2 with risk of Parkinson's disease (PD; adjusted odd ratio = 3.25; 95% CI = 1.80-5.87). ...

Biochemical and genetic evidence for the presence of multiple phosphatidylinositol- and phosphatidylinositol 4,5-bisphosphate-specific phospholipases C in Tetrahymena

Leondaritis, G.; Sarri, T.; Dafnis, I.; Efstathiou, A.; Galanopoulou, D. (2011)

Eukaryotic phosphoinositide-specific phospholipases C (PI-PLC) specifically hydrolyze phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2], produce the Ca2+-mobilizing agent inositol 1,4,5-trisphosphate, and regulate ...

Biochemical and in silico identification of the active site and the catalytic mechanism of the circadian deadenylase HESPERIN

Beta R.A.A., Kyritsis A., Douka V., Papanastasi E., Rizouli M., Leonidas D.D., Vlachakis D., Balatsos N.A.A. (2022)

The 24-h molecular clock is based on the stability of rhythmically expressed transcripts. The shortening of the poly(A) tail of mRNAs is often the first and rate-limiting step that determines the lifespan of a mRNA and is ...

Challenges in microbially and chelate-assisted phytoextraction of cadmium and lead – A review

Gul I., Manzoor M., Hashim N., Shah G.M., Waani S.P.T., Shahid M., Antoniadis V., Rinklebe J., Arshad M. (2021)

Cadmium (Cd) and lead (Pb) are ubiquitously present in surface soils, due to anthropogenic activities, causing threat to ecological and human health because of their carcinogenic nature. They accumulate in large quantities ...

Characterization of a novel lsa(E)- and lnu(B)-carrying structure located in the chromosome of a Staphylococcus aureus sequence type 398 strain

Sarrou S., Liakopoulos A., Tsoumani K., Sagri E., Mathiopoulos K.D., Tzouvelekis L.S., Miriagou V., Petinaki E. (2016)

[No abstract available]

Clinical immunology quiz-Case 6

Speletas, M.; Boukas, K.; Louies, G.; Germenis, A. E. (2009)

Colistin resistant mcr genes prevalence in livestock animals (Swine, bovine, poultry) from a multinational perspective. a systematic review

Valiakos G., Kapna I. (2021)

The objective of this review is to collect and present the results of relevant studies on an international level, on the subject of colistin resistance due to mcr genes prevalence in livestock animals. After a literature ...

Comparative Analysis of SARS-CoV-2 Variants of Concern, Including Omicron, Highlights Their Common and Distinctive Amino Acid Substitution Patterns, Especially at the Spike ORF

Nikolaidis M., Papakyriakou A., Chlichlia K., Markoulatos P., Oliver S.G., Amoutzias G.D. (2022)

In order to gain a deeper understanding of the recently emerged and highly divergent Omicron variant of concern (VoC), a study of amino acid substitution (AAS) patterns was performed and compared with those of the other ...

Complete exon 2 sequence of the HLA-DPA1*03:01 allele by sequence-based typing

Sarri C.A., Markantoni M., Hadjichristodoulou C., Mamuris Z. (2016)

Contribution of the CFTR gene, the pancreatic secretory trypsin inhibitor gene (SPINK1) and the cationic trypsinogen gene (PRSS1) to the etiology of recurrent pancreatitis

Tzetis, M.; Kaliakatsos, M.; Fotoulaki, B.; Papatheodorou, A.; Doudounakis, S.; Tsezou, A.; Makrythanasis, P.; Kanavakis, E.; Nousia-arvanitakis, S. (2007)

Acute recurrent/chronic pancreatitis (CP) is a complex multigenic disease. This is a case-control study consisting of 25 Greek patients with CP and a control population of 236 healthy Greek subjects. The whole coding area ...

Cytological and other aspects of pathogenesis-related gene expression in tomato plants grown on a suppressive compost

Kavroulakis, N.; Papadopoulou, K. K.; Ntougias, S.; Zervakis, G. I.; Ehaliotis, C. (2006)

• Background and Aims: Recent studies have shown that certain composts may trigger indirect defence mechanisms by sensitizing the plant to create an increased state of resistance, similar to systemic acquired resistance. ...

Detection of negative and positive RNA strand of poliovirus Sabin 1 and echovirus E19 by a stem-loop reverse transcription PCR

Fikatas A., Dimitriou T.G., Kyriakopoulou Z., Moschonas G.D., Amoutzias G.D., Mossialos D., Gartzonika C., Levidiotou-Stefanou S., Markoulatos P. (2017)

In this report a strand specific RT-PCR was established for the detection of the replicative negative RNA strand of poliovirus sabin 1 (Sabin1) and Echovirus 19 (E19) strains. The key for the successful conduction of the ...

Detection of unusual mutation within the VP1 region of different re-isolates of poliovirus Sabin vaccine

Dedepsidis, E.; Karakasiliotis, I.; Paximadi, E.; Kyriakopoulou, Z.; Komiotis, D.; Markoulatos, P. (2006)

In the present study, a genomic analysis of full VP1 sequence region of 15 clinical re-isolates (14 healthy vaccinees and one bone marrow tumor patient) was conducted, aiming to the identification of mutations and to the ...

DIANA-miRGen v4: Indexing promoters and regulators for more than 1500 microRNAs

Perdikopanis N., Georgakilas G.K., Grigoriadis D., Pierros V., Kavakiotis I., Alexiou P., Hatzigeorgiou A. (2021)

Deregulation of microRNA (miRNA) expression plays a critical role in the transition from a physiological to a pathological state. The accurate miRNA promoter identification in multiple cell types is a fundamental endeavor ...

Direct detection of Cardiobacterium hominis in serum from a patient with infective endocarditis by broad-range bacterial PCR

Gatselis, N.; Malli, E.; Papadamou, G.; Petinaki, E.; Dalekos, G. N. (2006)

Bacterial DNA was detected directly to the serum of a patient with endocarditis by broad-range 16S rRNA PCR followed by sequencing and analysis of the results by the BLAST search. Using these methods, Cardiobacterium hominis ...