Πλοήγηση ανά Θέμα "RNA"

4-Arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects

Kryštof, V.; Cankař, P.; Fryšová, I.; Slouka, J.; Kontopidis, G.; Džubák, P.; Hajdúch, M.; Srovnal, J.; De Azevedo Jr, W. F.; Orság, M.; Paprskářová, M.; Rolčík, J.; Látr, A.; Fischer, P. M.; Strnad, M. (2006)

In a routine screening of our small-molecule compound collection we recently identified 4-arylazo-3,5-diamino-1H-pyrazoles as a novel group of ATP antagonists with moderate potency against CDK2-cyclin E. A preliminary SAR ...

Acinetobacter baumannii antibiotic resistance mechanisms

Kyriakidis I., Vasileiou E., Pana Z.D., Tragiannidis A. (2021)

Acinetobacter baumannii is a Gram-negative ESKAPE microorganism that poses a threat to public health by causing severe and invasive (mostly nosocomial) infections linked with high mortality rates. During the last years, ...

Advanced intrahepatic cholangiocarcinoma in hepatitis C virus-related decompensated cirrhosis: case report and review of the literature

Polizos, A.; Kelekis, N.; Sinani, C.; Patsiaoura, K.; Papadamou, G.; Dalekos, G. N. (2003)

A 75-year-old man with no known previous liver disease was admitted to our institution because of right pleural effusion, backache, and pain in the upper right quadrant. Physical and laboratory work-up revealed decompensated ...

Anti-HDV immunoglobulin M testing in hepatitis delta revisited: correlations with disease activity and response to pegylated interferon-alpha 2a treatment

Mederacke, I.; Yurdaydin, C.; Dalekos, G. N.; Bremer, B.; Erhardt, A.; Cakaloglu, Y.; Yalcin, K.; Gurel, S.; Zeuzem, S.; Zachou, K.; Bozkaya, H.; Dienes, H. P.; Manns, M. P.; Wedemeyer, H.; Hep-Net Int Delta Hepatitis, Study (2012)

Background: The role of anti-HDV immunoglobulin M (IgM) testing in patients receiving pegylated interferon-alpha therapy for hepatitis delta is unknown. We performed anti-HDV IgM testing in a well defined cohort of HDVinfected ...

Assessment of the effects of oxamyl on the bacterial community of an agricultural soil exhibiting enhanced biodegradation

Gallego S., Devers-Lamrani M., Rousidou K., Karpouzas D.G., Martin-Laurent F. (2019)

Modern agricultural practices largely rely on pesticides to protect crops against various pests and to ensure high yields. Following their application to crops a large amount of pesticides ends up in soil where they may ...

Biomedical Data Ensemble Classification using Random Projections

Tasoulis S.K., Vrahatis A.G., Georgakopoulos S.V., Plagianakos V.P. (2019)

Biomedicine is undergoing a revolution driven by the explosion of biomedical data, which are generated by emerged medical imaging, sensor technologies and high-throughput technologies. An indicative example is the single ...

BUFET: Boosting the unbiased miRNA functional enrichment analysis using bitsets

Zagganas K., Vergoulis T., Paraskevopoulou M.D., Vlachos I.S., Skiadopoulos S., Dalamagas T. (2017)

Background: A group of miRNAs can regulate a biological process by targeting genes involved in the process. The unbiased miRNA functional enrichment analysis is the most precise in silico approach to predict the biological ...

Cancer's smart bombs: Tumor-derived exosomes target lung epithelial cells triggering pre-metastatic niche formation

Antonopoulos D., Balatsos N.A.A., Gourgoulianis K.I. (2017)

[No abstract available]

Changes in heterotrophic Picoplankton community structure after induction of a phytoplankton bloom under different light regimes

Karayanni H., Kormas K.A., Moustaka-Gouni M., Sommer U. (2019)

Bacterial and archaeal diversity and succession were studied during a mesocosm experiment that investigated whether changing light regimes could affect the onset of phytoplankton blooms. For this, 454-pyrosequencing of the ...

Changes in the level of poly(Phe) synthesis in Escherichia coli ribosomes containing mutants of L4 ribosomal protein from Thermus thermophilus can be explained by structural changes in the peptidyltransferase center: a molecular dynamics simulation analysis

Papadopoulos, G.; Grudinin, S.; Kalpaxis, D. L.; Choli-Papadopoulou, T. (2006)

Data from polyphenylalanine [poly(Phe)] synthesis determination in the presence and in the absence of erythromycin have been used in conjunction with Molecular Dynamics Simulation analysis, in order to localize the functional ...

Circulating biomarkers for cardiovascular diseases: The beats never stop editorial

Xi L., Kouvelos G., Paolocci N. (2018)

[No abstract available]

Correlation between intermediary metabolism, Hsp gene expression, and oxidative stress-related proteins in long-term thermal-stressed Mytilus galloprovincialis

Feidantsis K., Giantsis I.A., Vratsistas A., Makri S., Pappa A.-Z., Drosopoulou E., Anestis A., Mavridou E., Exadactylos A., Vafidis D., Michaelidis B. (2020)

Long-term exposure of Mytilus galloprovincialis to temperatures beyond 26°C triggers mussel mortality. The present study aimed to integratively illustrate the correlation between intermediary metabolism, hsp gene expression, ...

Correlation between recombination junctions and RNA secondary structure elements in poliovirus Sabin strains

Dedepsidis, E.; Kyriakopoulou, Z.; Pliaka, V.; Markoulatos, P. (2010)

In order to test the hypothesis that RNA structural elements promote the distribution of certain types of recombination junctions in each one of the 2C and 3D poliovirus genomic regions (Sabin 3/Sabin 2 or Sabin 1 in 2C ...

Decreased Expression of the CD3ζ Chain in T Cells Infiltrating the Synovial Membrane of Patients with Osteoarthritis

Sakkas, L. I.; Koussidis, G.; Avgerinos, E.; Gaughan, J.; Platsoucas, C. D. (2004)

Osteoarthritis (OA) is a heterogeneous disease which rheumatologists consider to be noninflammatory. However, recent studies suggest that, at least in certain patients, OA is an inflammatory disease and that patients often ...

Detection of negative and positive RNA strand of poliovirus Sabin 1 and echovirus E19 by a stem-loop reverse transcription PCR

Fikatas A., Dimitriou T.G., Kyriakopoulou Z., Moschonas G.D., Amoutzias G.D., Mossialos D., Gartzonika C., Levidiotou-Stefanou S., Markoulatos P. (2017)

In this report a strand specific RT-PCR was established for the detection of the replicative negative RNA strand of poliovirus sabin 1 (Sabin1) and Echovirus 19 (E19) strains. The key for the successful conduction of the ...