Πλοήγηση ανά Θέμα "Leporidae"

Adhesion Prevention to Polypropylene Meshes Using Combined Icodextrin Four Percent and Dimetindene Maleate

Bouliaris K., Asprodini E., Liakos P., Diamantis A., Koukoulis G., Befani C., Tzika S., Tepetes K. (2019)

Background: The use of surgical meshes in ventral hernia repair has significantly reduced hernia recurrence rates. However, when placed intraperitoneally prosthetic materials can trigger the development of peritoneal ...

Affinity Crystallography Reveals Binding of Pomegranate Juice Anthocyanins at the Inhibitor Site of Glycogen Phosphorylase: The Contribution of a Sugar Moiety to Potency and Its Implications to the Binding Mode

Drakou C.E., Gardeli C., Tsialtas I., Alexopoulos S., Mallouchos A., Koulas S.M., Tsagkarakou A.S., Asimakopoulos D., Leonidas D.D., Psarra A.-M.G., Skamnaki V.T. (2020)

Anthocyanins (ACNs) are dietary phytochemicals with an acknowledged therapeutic significance. Pomegranate juice (PJ) is a rich source of ACNs with potential applications in nutraceutical development. Glycogen phosphorylase ...

Contrast-induced nephropathy in an animal model: Evaluation of novel biomarkers in blood and tissue samples

Mamoulakis C., Fragkiadoulaki I., Karkala P., Georgiadis G., Zisis I.-E., Stivaktakis P., Kalogeraki A., Tsiaoussis I., Burykina T., Lazopoulos G., Tsarouhas K., Kouretas D., Tsatsakis A. (2019)

Identification of novel biomarkers of contrast-induced nephropathy (CIN)that may more accurately detect renal function changes; reflect kidney damage; assist monitoring; and elucidate pathophysiology attract considerable ...

The contribution of a collagen patch coated with fibrin glue in sealing upper gastrointestinal defects: An experimental study

CHRISTODOULIDIS G., SAMARA A.A., FLOROS T., KARAKANTAS K.-S., ZOTOS P.-A., KOUTRAS A., TEPETES K. (2021)

Background/Aim: We aimed to evaluate the safety and efficacy of sealing primary upper gastrointestinal (GI) perforations with a collagen patch coated with fibrin glue (Tachosil®). Materials and Methods: Thirty New Zealand ...

Do trabecular metal and cancellous titanium implants reduce the risk of late haematogenous infection? An experimental study in rabbits

Komnos G., Banios K., Kolonia K., Poultsides L.A., Petinaki E., Sarrou S., Zintzaras E., Karachalios T. (2021)

Aim: This study evaluated the late resistance to haematogenous contamination by microbial pathogens of implants and bone-implant interface and the development of late clinical infection when cementless components with ...

Dose-Dependent Effects of Ranolazine on Reentrant Ventricular Arrhythmias Induced After Subacute Myocardial Infarction in Rabbits

Moschovidis V., Simopoulos V., Stravela S., Dipla K., Hatziefthimiou A., Stamatiou R., Aidonidis I. (2020)

Ranolazine has been found to prevent ventricular arrhythmias (VAs) during acute myocardial infarction (AMI). This study aimed to investigate its efficacy on VAs induced several days post-MI. For this purpose, 13 anesthetized ...

Elevated PaCO2 levels increase pulmonary artery pressure

Triantaris A., Aidonidis I., Hatziefthimiou A., Gourgoulianis K., Zakynthinos G., Makris D. (2022)

Permissive hypercapnia is commonly used in mechanically ventilated patients to avoid lung injury but its effect on pulmonary artery pressure (PAP) is still unclear, particularly in combination with tidal volume (Vt). ...

Evidence of blood and muscle redox status imbalance in experimentally induced renal insufficiency in a rabbit model

Poulianiti K.P., Karioti A., Kaltsatou A., Mitrou G.I., Koutedakis Y., Tepetes K., Christodoulidis G., Giakas G., Maridaki M.D., Stefanidis I., Jamurtas A.Z., Sakkas G.K., Karatzaferi C. (2019)

Chronic kidney disease (CKD) is accompanied by a disturbed redox homeostasis, especially in end-stage patients, which is associated with pathological complications such as anemia, atherosclerosis, and muscle atrophy. ...

Evidence of functional deficits at the single muscle fiber level in experimentally-induced renal insufficiency

Mitrou G.I., Sakkas G.K., Poulianiti K.P., Karioti A., Tepetes K., Christodoulidis G., Giakas G., Stefanidis I., Geeves M.A., Koutedakis Y., Karatzaferi C. (2019)

Chronic kidney disease patients present with metabolic and functional muscle abnormalities, called uremic myopathy, whose mechanisms have not yet been fully elucidated. We investigated whether chronic renal insufficiency ...

An Experimental Model on the Biomechanical Behaviour of the Flexor Tendons in New Zealand Rabbits

Skouteris D., Magnissalis E., Papalois A., Varitimidis S., Papagelopoulos P.J., Zoubos A.B. (2017)

BACKGROUND: In order to introduce new pharmacological agents with the intent to inhibit the adhesion formation, it is important to test such products on laboratory animals under a protocol that can evaluate the quantitative ...

Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography

Szabó K.E., Kyriakis E., Psarra A.-M.G., Karra A.G., Sipos Á., Docsa T., Stravodimos G.A., Katsidou E., Skamnaki V.T., Liggri P.G.V., Zographos S.E., Mándi A., Király S.B., Kurtán T., Leonidas D.D., Somsák L. (2019)

Epimeric series of aryl-substituted glucopyranosylidene-spiro-imidazolinones, an unprecedented new ring system, were synthesized from the corresponding Schiff bases of O-perbenzoylated (gluculopyranosylamine)onamides by ...

Glycogen phosphorylase revisited: Extending the resolution of the R- And T-state structures of the free enzyme and in complex with allosteric activators

Leonidas D.D., Zographos S.E., Tsitsanou K.E., Skamnaki V.T., Stravodimos G., Kyriakis E. (2021)

The crystal structures of free T-state and R-state glycogen phosphorylase (GP) and of R-state GP in complex with the allosteric activators IMP and AMP are reported at improved resolution. GP is a validated pharmaceutical ...

Histopathological evaluation and redox assessment in blood and kidney tissues in a rabbit contrast-induced nephrotoxicity model

Tsamouri M.-M., Rapti M., Kouka P., Nepka C., Tsarouhas K., Soumelidis A., Koukoulis G., Tsatsakis A., Kouretas D., Tsitsimpikou C. (2017)

Contrast-induced nephropathy (CIN) is a leading cause of hospital-acquired acute kidney injury as a result of iodinated contrast-media use for diagnostic purposes. Pathophysiology remains unclear. In the present study ...

Histopathological evaluation of a retinoic acid eluting stent in a rabbit iliac artery model

Samara I., Katsouras C.S., Semertzioglou A., Vratimos A., Moula A.I., Dimitriou C.A., Theofanis M., Papadimitropoulou T., Bouratzis V., Karanasiou G., Fotiadis D., Michalis L.K., Moulas A.N. (2022)

This study aimed to evaluate the safety and efficacy of innovative retinoic acid (RA) eluting stents with bioabsorbable polymer. Sixty stents divided in ten groups were implanted in the iliac arteries of 30 rabbits. Two ...

In Vivo Estimation of the Biological Effects of Endocrine Disruptors in Rabbits after Combined and Long-Term Exposure: Study Protocol

Karzi V., Tzatzarakis M.N., Alegakis A., Vakonaki E., Fragkiadoulaki I., Kaloudis K., Chalkiadaki C., Apalaki P., Panagiotopoulou M., Kalliantasi A., Kouretas D., Docea A.O., Calina D., Tsatsakis A. (2022)

Recently, an increasing number of chemical compounds are being characterized as endocrine disruptors since they have been proven to interact with the endocrine system, which plays a crucial role in the maintenance of ...

The metabolism of imidacloprid by aldehyde oxidase contributes to its clastogenic effect in New Zealand rabbits

Vardavas A.I., Ozcagli E., Fragkiadaki P., Stivaktakis P.D., Tzatzarakis M.N., Alegakis A.K., Vasilaki F., Kaloudis K., Tsiaoussis J., Kouretas D., Tsitsimpikou C., Carvalho F., Tsatsakis A.M. (2018)

Imidacloprid (IMI) is a systemic, chloro-nicotinyl insecticide classified in Regulation N° 1272/2008 of the European Commision as “harmful if swallowed and very toxic to aquatic life, with long-lasting effects”. IMI is ...

Modulators of actin-myosin dissociation: Basis for muscle type functional differences during fatigue

Karatzaferi C., Adamek N., Geeves M.A. (2017)

The muscle types present with variable fatigue tolerance, in part due to the myosin isoform expressed. However, the critical steps that define “fatigability” in vivo of fast vs. slow myosin isoforms, at the molecular level, ...

A multidisciplinary study of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors

Kun S., Begum J., Kyriakis E., Stamati E.C.V., Barkas T.A., Szennyes E., Bokor É., Szabó K.E., Stravodimos G.A., Sipos Á., Docsa T., Gergely P., Moffatt C., Patraskaki M.S., Kokolaki M.C., Gkerdi A., Skamnaki V.T., Leonidas D.D., Somsák L., Hayes J.M. (2018)

3-(β-D-Glucopyranosyl)-5-substituted-1,2,4-triazoles have been revealed as an effective scaffold for the development of potent glycogen phosphorylase (GP) inhibitors but with the potency very sensitive to the nature of the ...

The muscarinic antagonist gallamine induces proliferation of airway smooth muscle cells regardless of the cell phenotype

Stamatiou R., Paraskeva E., Vasilaki A., Hatziefthimiou A. (2019)

Background: Muscarinic receptor antagonists are a usual treatment for chronic airway diseases, with increased bronchoconstriction, like asthma and chronic obstructive pulmonary disease. These diseases are usually accompanied ...

Nanomolar Inhibitors of Glycogen Phosphorylase Based on β- D -Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study

Bokor E., Kyriakis E., Solovou T.G.A., Koppány C., Kantsadi A.L., Szabó K.E., Szakács A., Stravodimos G.A., Docsa T., Skamnaki V.T., Zographos S.E., Gergely P., Leonidas D.D., Somsák L. (2017)

Aryl substituted 1-(β-d-glucosaminyl)-1,2,3-triazoles as well as C-β-d-glucosaminyl 1,2,4-triazoles and imidazoles were synthesized and tested as inhibitors against muscle and liver isoforms of glycogen phosphorylase (GP). ...