Πλοήγηση ανά Θέμα "GENE"

Abnormal serum concentrations of proteins in Parkinson's disease

Goldknopf, I. L.; Bryson, J. K.; Strelets, I.; Quintero, S.; Sheta, E. A.; Mosqueda, M.; Park, H. R.; Appel, S. H.; Shill, H.; Sabbagh, M.; Chase, B.; Kaldjian, E.; Markopoulou, K. (2009)

Blood serum was used to identify protein biomarkers for diagnosis of Parkinson's disease (PD) using analytically validated quantitative 2D-gel electrophoresis, and single variable and multivariate statistics. Using banked ...

Angiotensin-converting enzyme insertion/deletion gene polymorphic variant as a marker of coronary artery disease - A meta-analysis

Zintzaras, E.; Raman, G.; Kitsios, G.; Lau, J. (2008)

Background: Many studies have investigated the association between the angiotensin-converting enzyme (ACE) gene insertion(I)/deletion (D) polymorphic variant and coronary artery disease (CAD). However, the evidence is ...

Angiotensin-converting enzyme tag single nucleotide polymorphisms in patients with intracerebral hemorrhage

Dardiotis, E.; Jagiella, J.; Xiromerisiou, G.; Dardioti, M.; Vogiatzi, C.; Urbanik, A.; Paterakis, K.; Komnos, A.; Fountas, K. N.; Slowik, A.; Hadjigeorgiou, G. M. (2011)

Objectives Studies investigating the association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the risk of intracerebral hemorrhage (ICH) have provided conflicting results. Moreover, ...

Apolipoprotein E polymorphism is not associated with spinal bone mineral density in peri- and postmenopausal Greek women

Efstathiadou, Z.; Koukoulis, G.; Stakias, N.; Challa, A.; Tsatsoulis, A. (2004)

Objectives: A number of studies have shown a positive relation between ApoE gene and osteoporosis or fracture risk but this finding has not been uniform in all populations studied. The aim of the present study was to ...

Association of a BMP5 microsatellite with knee osteoarthritis: case-control study

Rodriguez-Fontenla, C.; Carr, A.; Gomez-Reino, J. J.; Tsezou, A.; Loughlin, J.; Gonzalez, A. (2012)

Introduction: We aimed to explore the involvement of a multiallelic functional polymorphism in knee osteoarthritis (OA) susceptibility as a prototype of possible genetic factors escaping GWAS detection. Methods: OA patients ...

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study

Ross, O. A.; Soto-Ortolaza, A. I.; Heckman, M. G.; Aasly, J. O.; Abahuni, N.; Annesi, G.; Bacon, J. A.; Bardien, S.; Bozi, M.; Brice, A.; Brighina, L.; Van Broeckhoven, C.; Carr, J.; Chartier-Harlin, M. C.; Dardiotis, E.; Dickson, D. W.; Diehl, N. N.; Elbaz, A.; Ferrarese, C.; Ferraris, A.; Fiske, B.; Gibson, J. M.; Gibson, R.; Hadjigeorgiou, G. M.; Hattori, N.; Ioannidis, J. P. A.; Jasinska-Myga, B.; Jeon, B. S.; Kim, Y. J.; Klein, C.; Kruger, R.; Kyratzi, E.; Lesage, S.; Lin, C. H.; Lynch, T.; Maraganore, D. M.; Mellick, G. D.; Mutez, E.; Nilsson, C.; Opala, G.; Park, S. S.; Puschmann, A.; Quattrone, A.; Sharma, M.; Silburn, P. A.; Sohn, Y. H.; Stefanis, L.; Tadic, V.; Theuns, J.; Tomiyama, H.; Uitti, R. J.; Valente, E. M.; van de Loo, S.; Vassilatis, D. K.; Vilarino-Guell, C.; White, L. R.; Wirdefeldt, K.; Wszolek, Z. K.; Wu, R. M.; Farrer, M. J.; Genetic Epidemiology Parkinson's, D. (2011)

Background The leucine-rich repeat kinase 2 gene (LRRK2) harbours highly penetrant mutations that are linked to familial parkinsonism. However, the extent of its polymorphic variability in relation to risk of Parkinson's ...

An Association Study between Hypoxia Inducible Factor-1alpha (HIF-1 alpha) Polymorphisms and Osteonecrosis

Chachami, G.; Kalousi, A.; Papatheodorou, L.; Lyberopoulou, A.; Nasikas, V.; Tanimoto, K.; Simos, G.; Malizos, K. N.; Georgatsou, E. (2013)

Bone hypoxia resulting from impaired blood flow is the final pathway for the development of osteonecrosis (ON). The aim of this study was to evaluate if HIF-1 alpha, the major transcription factor triggered by hypoxia, is ...

Basal cell carcinoma in a dog with chronic solar dermatitis

Saridomichelakis, M. N.; Day, M. J.; Apostolidis, K. N.; Tsioli, V.; Athanasiou, L. V.; Koutinas, A. F. (2013)

A seven-year-old, entire male, American Staffordshire bull terrier was diagnosed with chronic solar dermatitis and basal cell carcinoma, based on physical examination, cutaneous cytology and histopathology. Immunohistochemistry ...

Bax protein expression in colorectal cancer: Association with p53, bcl-2 and patterns of relapse

Giatromanolaki, A.; Sivridis, E.; Stathopoulos, G. P.; Fountzilas, G.; Kalofonos, H. P.; Tsamandas, A.; Vrettou, E.; Scopa, C.; Polychronidis, A.; Simopoulos, K.; Koukourakis, M. I. (2001)

This study evaluated the frequency and the prognostic significance of bax, bcl-2 and p53 proteins in stage B and C adenocarcinomas of the colon and rectum. Paraffin-embedded specimens from 268 patients with colorectal ...

Bone morphogenetic proteins (BMPs) expression in the femoral heads of patients with avascular necrosis

Samara, S.; Dailiana, Z.; Varitimidis, S.; Chassanidis, C.; Koromila, T.; Malizos, K. N.; Kollia, P. (2013)

Avascular necrosis (AVN) is a disorder of the bone repair process which usually results in femoral head (FH) destruction. Bone morphogenetic proteins (BMPs) are the key proteins regulating bone remodelling and healing. ...

Central Role of SREBP-2 in the Pathogenesis of Osteoarthritis

Kostopoulou, F.; Gkretsi, V.; Malizos, K. N.; Iliopoulos, D.; Oikonomou, P.; Poultsides, L.; Tsezou, A. (2012)

Background: Recent studies have implied that osteoarthritis (OA) is a metabolic disease linked to deregulation of genes involved in lipid metabolism and cholesterol efflux. Sterol Regulatory Element Binding Proteins (SREBPs) ...

Characterization of Metallo-beta-Lactamase VIM-27, an A57S Mutant of VIM-1 Associated with Klebsiella pneumoniae ST147

Papagiannitsis, C. C.; Kotsakis, S. D.; Petinaki, E.; Vatopoulos, A. C.; Tzelepi, E.; Miriagou, V.; Tzouvelekis, L. S. (2011)

VIM-27 metallo-beta-lactamase, an Ala(57) -> Ser variant of VIM-1, was identified in three Klebsiella pneumoniae isolates belonging to sequence type 147. bla(VIM-27) was part of a class 1 integron carried by non-self-transferable ...

Clinical, neuropathological and genotypic variability in SNCA A53T familial Parkinson's disease

Markopoulou, K.; Dickson, D. W.; McComb, R. D.; Wszolek, Z. K.; Katechalidou, L.; Avery, L.; Stansbury, M. S.; Chase, B. A. (2008)

Individuals with familial Parkinson's disease (PD) due to a monogenic defect can show considerable clinical and neuropathological variability. To identify factors underlying this variability, histopathological analysis was ...

Clusters of imipenem-resistant Acinetobacter baumannii clones producing different carbapenemases in an intensive care unit

Tsakris, A.; Ikonomidis, A.; Poulou, A.; Spanakis, N.; Vrizas, D.; Diomidous, M.; Pournaras, S.; Markou, F. (2008)

During a 2-year period (April 2005-March 2007), 31 intensive care unit (ICU) patients in a Greek hospital were infected or colonised with imipenem-resistant isolates of Acinetobacter baumannii. Twelve patients died, with ...

Comparative effects of hypoxia on normal and immortalized human diploid fibroblasts

Poulios, E.; Trougakos, I. P.; Gonos, E. S. (2006)

Hypoxia, a condition of reduced oxygen concentration, is observed in many physiological and pathophysiological states. However, there is rather limited information regarding hypoxic effects in the processes of immortalization ...

Complete nucleotide sequence analysis of the VP1 genomic region of Echoviruses 6 isolated from sewage in Greece revealed 98% similarity with Echoviruses 6 that were characterized from an aseptic meningitis outbreak 1 year later

Kyriakopoulou, Z.; Dedepsidis, E.; Pliaka, V.; Tsakogiannis, D.; Ruether, I. G. A.; Krikelis, A.; Markoulatos, P. (2011)

The molecular characterization of two enterovirus strains (LR51A5 and LR61G3) isolated from the sewage treatment plant unit in Larissa, Greece, in May and June 2006 and the investigation of their relationship with enteroviruses ...

Compound heterozygosity of non-deletional hereditary persistence of fetal hemoglobin and delta beta-thalassemia

Kalamaras, A.; Chassanidis, C.; Samara, M.; Papadakis, M. N.; Vagena, A.; Aleporou-Marinou, V.; Patrinos, G. P.; Kollia, P. (2008)

Correlation between radiation-induced telomerase activity and human telomerase reverse transcriptase mRNA expression in HeLa cells

Satra, M.; Tsougos, I.; Papanikolaou, V.; Theodorou, K.; Kappas, C.; Tsezou, A. (2006)

Purpose: To quantify and correlate human telomerase reverse transcriptase (hTERT) mRNA expression with telomerase activity (TA) after ionizing irradiation of HeLa cells. Materials and methods: TA and hTERT mRNA expression ...

Deletion 2q31.2-q31.3 in a 4-Year-Old Girl With Microcephaly and Severe Mental Retardation

Manolakos, E.; Vetro, A.; Kefalas, K.; Thomaidis, L.; Aperis, G.; Sotiriou, S.; Kitsos, G.; Merkas, M.; Sifakis, S.; Papoulidis, I.; Liehr, T.; Zuffardi, O.; Petersen, M. B. (2011)

Detection of a phylogenetically distinct IMP-type metallo-beta-lactamase, IMP-35, in a CC235 Pseudomonas aeruginosa from the Dutch-German border region (Euregio)

Pournaras, S.; Kock, R.; Mossialos, D.; Mellmann, A.; Sakellaris, V.; Stathopoulos, C.; Friedrich, A. W.; Tsakris, A. (2013)

To characterize a highly divergent IMP-type metallo--lactamase (MBL) variant detected in a multidrug-resistant Pseudomonas aeruginosa clinical isolate. P. aeruginosa isolate 1876 was recovered from an anal swab of an ...