Πλοήγηση ανά Συγγραφέα "Xiromerisiou, G."

A1-antichymotrypsin gene polymorphism and cerebral hemorrhagic events in patients with traumatic brain injury

Dardioti, M.; Dardiotis, E.; Aggelakis, K.; Tasiou, A.; Paterakis, K.; Komnos, A.; Karantanas, A.; Xiromerisiou, G.; Papadimitriou, A.; Hadjigeorgiou, G. (2005)

Absence of aprataxin gene mutations in a Greek cohort with sporadic early onset ataxia and normal GAA triplets in frataxin gene

Daiou, C.; Christodoulou, K.; Xiromerisiou, G.; Panas, M.; Dardiotis, E.; Kladi, A.; Speletas, M.; Ntaios, G.; Papadimitriou, A.; Germenis, A.; Hadjigeorgiou, G. M. (2010)

Phenotype of patients with the aprataxin gene mutation varies and according to previous studies, screening of aprataxin gene could be useful, once frataxin gene mutation is excluded in patients with normal GAA expansion ...

Alpha-1 antichymotrypsin gene signal peptide A/T polymorphism and primary intracerebral hemorrhage

Dardiotis, E.; Hadjigeorgiou, G. M.; Dardioti, M.; Scarmeas, N.; Paterakis, K.; Aggelakis, K.; Komnos, A.; Tasiou, A.; Xiromerisiou, G.; Gabranis, I.; Zintzaras, E.; Papadimitriou, A.; Karantanas, A. (2008)

Background/Aims: Alpha-1 antichymotrypsin (ACT), a serine proteinase inhibitor, has been implicated in vascular pathology. The TT genotype of the ACT signal peptide A/T polymorphism has been reported to confer susceptibility ...

Angiotensin-converting enzyme tag single nucleotide polymorphisms in patients with intracerebral hemorrhage

Dardiotis, E.; Jagiella, J.; Xiromerisiou, G.; Dardioti, M.; Vogiatzi, C.; Urbanik, A.; Paterakis, K.; Komnos, A.; Fountas, K. N.; Slowik, A.; Hadjigeorgiou, G. M. (2011)

Objectives Studies investigating the association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the risk of intracerebral hemorrhage (ICH) have provided conflicting results. Moreover, ...

Assessment of Parkinson's disease risk loci in Greece

Kara, E.; Xiromerisiou, G.; Spanaki, C.; Bozi, M.; Koutsis, G.; Panas, M.; Dardiotis, E.; Ralli, S.; Bras, J.; Letson, C.; Edsall, C.; Pliner, H.; Arepalli, S.; Kalinderi, K.; Fidani, L.; Bostantjopoulou, S.; Keller, M. F.; Wood, N. W.; Hardy, J.; Houlden, H.; Stefanis, L.; Plaitakis, A.; Hernandez, D.; Hadjigeorgiou, G. M.; Nalls, M. A.; Singleton, A. B. (2014)

Genome-wide association studies (GWAS) have been shown to be a powerful approach to identify risk loci for neurodegenerative diseases. Recent GWAS in Parkinson's disease (PD) have been successful in identifying numerous ...

Association between AKT1 gene and Parkinson's disease: A protective haplotype

Xiromerisiou, G.; Hadjigeorgiou, G. M.; Papadimitriou, A.; Katsarogiannis, E.; Gourbali, V.; Singleton, A. B. (2008)

Variation in AKT1 has been associated with schizophrenia, bipolar disease and type 11 diabetes. The aim of the present study was to investigate the potential role of variability within AKT1 as a risk factor for Parkinson's ...

Association between PIK3C2B gene and Parkinson's disease: evidence for involvement of the PI3K/AKT pathway

Xiromerisiou, G.; Dardiotis, E.; Kountra, P.; Patramani, I.; Vogiatzi, C.; Katsavaki, M.; Tsimourtou, V.; Ralli, S.; Markou, K.; Papadimitriou, A.; Hadjigeorgiou, G. (2010)

Association of alpha-synuclein Rep1 polymorphism with risk for Parkinson's disease and influence on age at onset of Parkinson's disease

Xiromerisiou, G.; Gourbali, V.; Aggelakis, K.; Dardiotis, E.; Tsimourtou, V.; Papadimitriou, A.; Papakonstantinou, I.; Scarmeas, N.; Singleton, A.; Hadjigeorgiou, G. (2005)

Association of tau haplotype-tagging polymorphisms with Parkinson's disease in diverse ethnic Parkinson's disease cohorts

Fung, H. C.; Xiromerisiou, G.; Gibbs, J. R.; Wu, Y. R.; Eerola, J.; Gourbali, V.; Hellstrom, O.; Chen, C. M.; Duckworth, J.; Papadimitriou, A.; Tienari, P. J.; Hadjigeorgiou, G. M.; Hardy, J.; Singleton, A. B. (2006)

Background: The overlap in the clinical and pathological features of tauopathies and synucleinopathies raises the possibility that the tau protein may be important in Parkinson's disease (PD) pathogenesis. Several MAPT ...

Association of α-synuclein Rep1 polymorphism and Parkinson's disease: Influence of Rep1 on age at onset

Hadjigeorgiou, G. H.; Xiromerisiou, G.; Gourbali, V.; Aggelakis, K.; Scarmeas, N.; Papadimitriou, A.; Singleton, A. (2006)

The α-synuclein Rep1 polymorphism was studied in patients and controls in an ethnic Greek population. There was an association of allele 2 with risk of Parkinson's disease (PD; adjusted odd ratio = 3.25; 95% CI = 1.80-5.87). ...

Association study of (VNTR) 1L-1RN and (-511) IL-1B gene polymorphisms and cerebral haemorrhagic events in patients with traumatic brain injury

Hadjigeorgiou, G.; Dardiotis, E.; Paterakis, K.; Dardioti, M.; Aggelakis, K.; Tasiou, A.; Xiromerisiou, G.; Karantanas, A.; Komnos, A.; Zintzaras, E.; Scarmeas, N.; Papadimitriou, A. (2005)

Autoantibodies to alpha-synuclein in inherited Parkinson's disease

Papachroni, K. K.; Ninkina, N.; Papapanagiotou, A.; Hadjigeorgiou, G. M.; Xiromerisiou, G.; Papadimitriou, A.; Kalofoutis, A.; Buchman, V. L. (2007)

Neurodegeneration in Parkinson's disease (PD) is accompanied by a local immune reaction in the affected brain regions. It is well established that alpha-synuclein is directly implicated in the pathogenesis of PD. Development ...

BDNF haplotype tagging SNPs in Greek sporadic PD patients and patterns of linkage disequilibrium

Xiromerisiou, G.; Tsimourtou, V.; Gourbali, V.; Aggelakis, K.; Dardiotis, E.; Dardioti, M.; Noulas, G.; Papadimitriou, A.; Singleton, A.; Hadjigeorgiou, G. (2006)

BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson's disease in diverse ethnic groups

Xiromerisiou, G.; Hadjigeorgiou, G. M.; Eerola, J.; Fernandez, H. H.; Tsimourtou, V.; Mandel, R.; Hellstrom, O.; Gwinn-Hardy, K.; Okun, M. S.; Tienari, P. J.; Singleton, A. B. (2007)

Experimental and clinical data suggest that genetic variations in brain-derived neurotrophic factor (BDNF) gene may affect risk for Parkinson's disease (PD). We performed a case-control association analysis of BDNF in three ...

beta-Glucocerebrosidase gene mutations in two cohorts of Greek patients with sporadic Parkinson's disease

Moraitou, M.; Hadjigeorgiou, G.; Monopolis, I.; Dardiotis, E.; Bozi, M.; Vassilatis, D.; Vilageliu, L.; Grinberg, D.; Xiromerisiou, G.; Stefanis, L.; Michelakakis, H. (2011)

An increasing number of clinical, neuropathological and experimental evidence linking Gaucher disease and a spectrum of synucleinopathies, including Parkinson's disease (PD) has emerged over the last decade. In particular, ...

Evidence of an association between the scavenger receptor class B member 2 gene and Parkinson's disease

Michelakakis, H.; Xiromerisiou, G.; Dardiotis, E.; Bozi, M.; Vassilatis, D.; Kountra, P. M.; Patramani, G.; Moraitou, M.; Papadimitriou, D.; Stamboulis, E.; Stefanis, L.; Zintzaras, E.; Hadjigeorgiou, G. M. (2012)

Lysosomal protein 2 (LIMP2), the product of the scavenger receptor class B member 2 (SCARB2) gene, is a ubiquitously expressed transmembrane protein that is the mannose-6-phosphateindependent receptor for glucocerebrosidase ...

Gain-of-function variant in GLUD2 glutamate dehydrogenase modifies Parkinson's disease onset

Plaitakis, A.; Latsoudis, H.; Kanavouras, K.; Ritz, B.; Bronstein, J. M.; Skoula, I.; Mastorodemos, V.; Papapetropoulos, S.; Borompokas, N.; Zaganas, I.; Xiromerisiou, G.; Hadjigeorgiou, G. M.; Spanaki, C. (2010)

Parkinson's disease (PD), a common neurodegenerative disorder characterized by progressive loss of dopaminergic neurons and their terminations in the basal ganglia, is thought to be related to genetic and environmental ...

Genetic association studies in patients with traumatic brain injury

Dardiotis, E.; Fountas, K. N.; Dardioti, M.; Xiromerisiou, G.; Kapsalaki, E.; Tasiou, A.; Hadjigeorgiou, G. M. (2010)

Traumatic brain injury (TBI) constitutes a major cause of mortality and disability worldwide, especially among young individuals. It is estimated that despite all the recent advances in the management of TBI, approximately ...

Genetic basis of Parkinson disease

Xiromerisiou, G.; Dardiotis, E.; Tsimourtou, V.; Kountra, P. M.; Paterakis, K. N.; Kapsalaki, E. Z.; Fountas, K. N.; Hadjigeorgiou, G. M. (2010)

Over the past few years, considerable progress has been made in understanding the molecular mechanisms of Parkinson disease (PD). Mutations in certain genes are found to cause monogenic forms of the disorder, with autosomal ...

Genetic susceptibility to primary intracerebral haemorrhage

Dardiotis, E.; Dardioti, M.; Xiromerisiou, G.; Paterakis, K.; Fountas, K.; Hadjigeorgiou, G. M. (2009)

Primary intracerebral haemorrhage (PICH) originates from the spontaneous rupture of cerebral arteries as a result of chronic degenerative alterations. Although the aetiology of PICH has not been fully elucidated, it may ...