Sfoglia per Soggetto "kidney proximal tubule"

Preconditioning of primary human renal proximal tubular epithelial cells without tryptophan increases survival under hypoxia by inducing autophagy

Eleftheriadis T., Pissas G., Sounidaki M., Antoniadis N., Antoniadi G., Liakopoulos V., Stefanidis I. (2017)

Purpose: Hypoxia plays a significant role in the pathogenesis of acute kidney injury (AKI). Autophagy protects from AKI. Amino acid deprivation induces autophagy. The effect of l-tryptophan depletion on survival and autophagy ...

Reoxygenation induces reactive oxygen species production and ferroptosis in renal tubular epithelial cells by activating aryl hydrocarbon receptor

Eleftheriadis T., Pissas G., Filippidis G., Liakopoulos V., Stefanidis I. (2021)

During the reperfusion phase of ischemia‑reper‑ fusion injury, reactive oxygen species (ROS) production aggravates the course of many diseases, including acute kidney injury. Among the various enzymes implicated in ROS ...

A role for human renal tubular epithelial cells in direct allo-recognition by CD4+ T-cells and the effect of ischemia-reperfusion

Eleftheriadis T., Pissas G., Crespo M., Nikolaou E., Liakopoulos V., Stefanidis I. (2021)

Direct allorecognition is the earliest and most potent immune response against a kidney allograft. Currently, it is thought that passenger donor professional antigen-presenting cells (APCs) are responsible. Further, many ...

Role of indoleamine 2,3-dioxygenase in ischemia-reperfusion injury of renal tubular epithelial cells

Eleftheriadis T., Pissas G., Golfinopoulos S., Liakopoulos V., Stefanidis I. (2021)

The present study evaluated indoleamine 2,3-dioxy- genase 1 (IDO) kinetics and how it affects cell survival during the two distinct phases of ischemia-reperfusion (I-R) injury. Primary renal proximal tubular epithelial ...

The role of indoleamine 2,3-dioxygenase in renal tubular epithelial cells senescence under anoxia or reoxygenation

Eleftheriadis T., Pissas G., Filippidis G., Liakopoulos V., Stefanidis I. (2021)

Ischemia-reperfusion injury is the commonest form of acute kidney injury (AKI). Tubular epithelial cell senescence contributes to incomplete recovery from AKI and predisposes to subsequent chronic kidney disease. In cultures ...

A unifying model of glucotoxicity in human renal proximal tubular epithelial cells and the effect of the SGLT2 inhibitor dapagliflozin

Eleftheriadis T., Pissas G., Tsogka K., Nikolaou E., Liakopoulos V., Stefanidis I. (2020)

Background: Glucotoxicity in renal tubular epithelial cells (RPTECs) contributes to the pathogenesis of diabetic nephropathy. Sodium-glucose cotransporter 2 (SGLT2) inhibitors may exert their renoprotective effect by ...