Sfoglia per Soggetto "enzyme activity"

17-β estradiol attenuates the pro-oxidant activity of corticotropin-releasing hormone in macroendothelial cells

Filiponi M., Gougoura S.G., Befani C., Bargiota Α., Liakos P., Koukoulis G.N. (2019)

Corticotropin-releasing hormone, which is the predominant regulator of neuroendocrine responses to stress, attenuates inflammation through stimulation of glucocorticoid release. Enhanced corticotropin-releasing hormone ...

3rd European Biobed Workshop

de Wilde, T.; Capri, E.; Husby, J.; Del Castillo, M. P.; Karpouzas, D.; Nilsson, E.; Spliid, N. H. (2011)

Administration of exercise-conditioned plasma alters muscle catalase kinetics in rat: An argument for in vivo-like Km instead of in vitro-like Vmax

Veskoukis A.S., Paschalis V., Kyparos A., Nikolaidis M.G. (2018)

Maximal velocity (Vmax) is a well established biomarker for the assessment of tissue redox status. There is scarce evidence, though, that it does not probably reflect sufficiently in vivo tissue redox profile. Instead, the ...

Affinity crystallography reveals the bioactive compounds of industrial juicing byproducts of Punica granatum for glycogen phosphorylase

Stravodimos G.A., Kantsadi A.L., Apostolou A., Kyriakis E., Kafaski-Kanelli V.-N., Solovou T., Gatzona P., Liggri P.G.V., Theofanous S., Gorgogietas V.A., Kissa A., Psachoula C., Lemonakis A., Chatzileontiadou D.S.M., Psarra A.-M.G., Skamnaki V.T., Haroutounian S.A., Leonidas D.E. (2018)

Background: Glycogen phosphorylase (GP) is a pharmaceutical target for the discovery of new antihyperglycaemic agents. Punica granatum is a well-known plant for its potent antioxidant and antimicrobial activities but so ...

Allopurinol protects human glomerular endothelial cells from high glucose-induced reactive oxygen species generation, p53 overexpression and endothelial dysfunction

Eleftheriadis T., Pissas G., Antoniadi G., Liakopoulos V., Stefanidis I. (2018)

Purpose: Mitochondrial reactive oxygen species (ROS) overproduction in capillary endothelial cells is a prerequisite for the development of diabetic nephropathy. Inhibition of xanthine oxidase, another ROS generator, ...

Alterations in xenobiotic-metabolizing enzyme activities across menstrual cycle in healthy volunteers

Asprodini E., Tsiokou V., Begas E., Kilindris T., Kouvaras E., Samara M., Messinis I. (2019)

The purpose of the study was to determine whether the in vivo activities of drug-metabolizing enzymes CYP1A2 and CYP2A6, xanthine oxidase (XO), and N-acetyltransferase-2 (NAT2) vary across the menstrual cycle. Forty-two ...

Altered activity of xenobiotic detoxifying enzymes at menopause – A cross-sectional study

Tsiokou V., Kilindris T., Begas E., Kouvaras E., Kouretas D., Asprodini E.K. (2020)

Xenobiotic metabolism at menopause is an under-investigated topic, albeit women spend one-third of their life in the postmenopausal period. The present study examined the effect of menopause on the in vivo activities of ...

The ammonium sulfate inhibition of human angiogenin

Chatzileontiadou D.S.M., Tsirkone V.G., Dossi K., Kassouni A.G., Liggri P.G.V., Kantsadi A.L., Stravodimos G.A., Balatsos N.A.A., Skamnaki V.T., Leonidas D.D. (2016)

In this study, we investigate the inhibition of human angiogenin by ammonium sulfate. The inhibitory potency of ammonium sulfate for human angiogenin (IC50 = 123.5 ± 14.9 mm) is comparable to that previously reported for ...

Antimicrobial activity of bee-collected pollen and beebread: State of the art and future perspectives

Didaras N.A., Karatasou K., Dimitriou T.G., Amoutzias G.D., Mossialos D. (2020)

Bee-collected pollen (BCP) is a well-known functional food. Honey bees process the collected pollen and store it in the hive, inside the comb cells. The processed pollen is called beebread or ambrosia and it is the main ...

Antioxidant responses following active and passive smoking of tobacco and electronic cigarettes

Poulianiti K., Karatzaferi C., Flouris A.D., Fatouros I.G., Koutedakis Y., Jamurtas A.Z. (2016)

Context: It has been indicated that acute active and passive tobacco cigarette smoking may cause changes on redox status balance that may result in significant pathologies. However, no study has evaluated the effects of ...

The architecture of hydrogen and sulfur σ-hole interactions explain differences in the inhibitory potency of C-β-D-glucopyranosyl thiazoles, imidazoles and an N-β-D glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design

Kyriakis E., Karra A.G., Papaioannou O., Solovou T., Skamnaki V.T., Liggri P.G.V., Zographos S.E., Szennyes E., Bokor É., Kun S., Psarra A.-M.G., Somsák L., Leonidas D.D. (2020)

C-Glucopyranosyl imidazoles, thiazoles, and an N-glucopyranosyl tetrazole were assessed in vitro and ex vivo for their inhibitory efficiency against isoforms of glycogen phosphorylase (GP; a validated pharmacological target ...

Assessment of the impact of three pesticides on microbial dynamics and functions in a lab-to-field experimental approach

Karas P.A., Baguelin C., Pertile G., Papadopoulou E.S., Nikolaki S., Storck V., Ferrari F., Trevisan M., Ferrarini A., Fornasier F., Vasileiadis S., Tsiamis G., Martin-Laurent F., Karpouzas D.G. (2018)

The toxicity of pesticides on soil microorganisms is as an emerging area of concern. Novel and well-standardized tools could be now used to provide a robust assessment of the ecotoxicity of pesticides on soil microorganisms. ...

Assessment of the redox status in patients with metabolic syndrome and type 2 diabetes reveals great variations

Spanidis Y., Mpesios A., Stagos D., Goutzourelas N., Bar-Or D., Karapetsa M., Zakynthinos E., Spandidos D.A., Tsatsakis A.M., Leon G., Kouretas D. (2016)

The aim of the present study was to examine the effectiveness of a new redox status marker, the static oxidation reduction potential (sORP), for assessing oxidative stress in 75 patients with metabolic syndrome (MetS) and ...

The associations between dairy product consumption and biomarkers of inflammation, adipocytokines, and oxidative stress in children: A cross-sectional study

Aslam H., Jacka F.N., Marx W., Karatzi K., Mavrogianni C., Karaglani E., Mohebbi M., Pasco J.A., O’neil A., Berk M., Nomikos T., Kanellakis S., Androutsos O., Manios Y., Moschonis G. (2020)

The association between dairy product consumption and biomarkers of inflammation, adipocytokines, and oxidative stress is poorly studied in children. Therefore, these associations were examined in a representative subsample ...

Asymmetric behavior of archaeal prolyl-tRNA synthetase

Ambrogelly, A.; Kamtekar, S.; Stathopoulos, C.; Kennedy, D.; Söll, D. (2005)

Archaeal prolyl-tRNA synthetases differ from their bacterial counterparts: they contain an additional domain (about 70 amino acids) appended to the carboxy-terminus and lack an editing domain inserted into the class II ...

Biochemical and in silico identification of the active site and the catalytic mechanism of the circadian deadenylase HESPERIN

Beta R.A.A., Kyritsis A., Douka V., Papanastasi E., Rizouli M., Leonidas D.D., Vlachakis D., Balatsos N.A.A. (2022)

The 24-h molecular clock is based on the stability of rhythmically expressed transcripts. The shortening of the poly(A) tail of mRNAs is often the first and rate-limiting step that determines the lifespan of a mRNA and is ...

Biofunctional Feed Supplemented with By-products of Olive Oil Production Improves Tissue Antioxidant Profile of Lambs

Makri S., Raftopoulou S., Kafantaris I., Kotsampasi B., Christodoulou V., Nepka C., Veskoukis A.S., Kouretas D. (2020)

Background/Aim: Olive mill wastewater (OMW) is a byproduct of olive oil production. The aim of the study was to estimate the redox profile of lambs' vital organs after consumption of an OMW-supplemented feed. Materials and ...

Biogenic amines in food as a public health concern an outline of histamine food poisoning

Chaidoutis E.A., Migdanis A., Keramydas D., Papalexis P. (2019)

Food-borne diseases have an important impact on public health. In recent years, epidemiological recording of diseases is ongoing, but more data are required for the assessment of food poisoning from biogenic amines. This ...

Biostimulants application: A low input cropping management tool for sustainable farming of vegetables

Shahrajabian M.H., Chaski C., Polyzos N., Petropoulos S.A. (2021)

Biostimulants, are a diverse class of compounds including substances or microorganism which have positive impacts on plant growth, yield and chemical composition as well as boosting effects to biotic and abiotic stress ...

Blame it on the metabolite: 3,5-dichloroaniline rather than the parent compound is responsible for the decreasing diversity and function of soil microorganisms

Vasileiadis S., Puglisi E., Papadopoulou E.S., Pertile G., Suciu N., Pappolla R.A., Tourna M., Karas P.A., Papadimitriou F., Kasiotakis A., Ipsilanti N., Ferrarini A., Sulowicz S., Fornasier F., Menkissoglu-Spiroudi U., Nicol G.W., Trevisan M., Karpouzas D.G. (2018)

Pesticides are key stressors of soil microorganisms with reciprocal effects on ecosystem functioning. These effects have been mainly attributed to the parent compounds, while the impact of their transformation products ...