Sfoglia per Soggetto "RNA"
Items 1-20 di 80
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4-Arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects
(2006)In a routine screening of our small-molecule compound collection we recently identified 4-arylazo-3,5-diamino-1H-pyrazoles as a novel group of ATP antagonists with moderate potency against CDK2-cyclin E. A preliminary SAR ... -
Acinetobacter baumannii antibiotic resistance mechanisms
(2021)Acinetobacter baumannii is a Gram-negative ESKAPE microorganism that poses a threat to public health by causing severe and invasive (mostly nosocomial) infections linked with high mortality rates. During the last years, ... -
Advanced intrahepatic cholangiocarcinoma in hepatitis C virus-related decompensated cirrhosis: case report and review of the literature
(2003)A 75-year-old man with no known previous liver disease was admitted to our institution because of right pleural effusion, backache, and pain in the upper right quadrant. Physical and laboratory work-up revealed decompensated ... -
Anti-HDV immunoglobulin M testing in hepatitis delta revisited: correlations with disease activity and response to pegylated interferon-alpha 2a treatment
(2012)Background: The role of anti-HDV immunoglobulin M (IgM) testing in patients receiving pegylated interferon-alpha therapy for hepatitis delta is unknown. We performed anti-HDV IgM testing in a well defined cohort of HDVinfected ... -
Assessment of the effects of oxamyl on the bacterial community of an agricultural soil exhibiting enhanced biodegradation
(2019)Modern agricultural practices largely rely on pesticides to protect crops against various pests and to ensure high yields. Following their application to crops a large amount of pesticides ends up in soil where they may ... -
Biomedical Data Ensemble Classification using Random Projections
(2019)Biomedicine is undergoing a revolution driven by the explosion of biomedical data, which are generated by emerged medical imaging, sensor technologies and high-throughput technologies. An indicative example is the single ... -
BUFET: Boosting the unbiased miRNA functional enrichment analysis using bitsets
(2017)Background: A group of miRNAs can regulate a biological process by targeting genes involved in the process. The unbiased miRNA functional enrichment analysis is the most precise in silico approach to predict the biological ... -
Cancer's smart bombs: Tumor-derived exosomes target lung epithelial cells triggering pre-metastatic niche formation
(2017)[No abstract available] -
Changes in heterotrophic Picoplankton community structure after induction of a phytoplankton bloom under different light regimes
(2019)Bacterial and archaeal diversity and succession were studied during a mesocosm experiment that investigated whether changing light regimes could affect the onset of phytoplankton blooms. For this, 454-pyrosequencing of the ... -
Changes in the level of poly(Phe) synthesis in Escherichia coli ribosomes containing mutants of L4 ribosomal protein from Thermus thermophilus can be explained by structural changes in the peptidyltransferase center: a molecular dynamics simulation analysis
(2006)Data from polyphenylalanine [poly(Phe)] synthesis determination in the presence and in the absence of erythromycin have been used in conjunction with Molecular Dynamics Simulation analysis, in order to localize the functional ... -
Circulating biomarkers for cardiovascular diseases: The beats never stop editorial
(2018)[No abstract available] -
Correlation between intermediary metabolism, Hsp gene expression, and oxidative stress-related proteins in long-term thermal-stressed Mytilus galloprovincialis
(2020)Long-term exposure of Mytilus galloprovincialis to temperatures beyond 26°C triggers mussel mortality. The present study aimed to integratively illustrate the correlation between intermediary metabolism, hsp gene expression, ... -
Correlation between recombination junctions and RNA secondary structure elements in poliovirus Sabin strains
(2010)In order to test the hypothesis that RNA structural elements promote the distribution of certain types of recombination junctions in each one of the 2C and 3D poliovirus genomic regions (Sabin 3/Sabin 2 or Sabin 1 in 2C ... -
Decreased Expression of the CD3ζ Chain in T Cells Infiltrating the Synovial Membrane of Patients with Osteoarthritis
(2004)Osteoarthritis (OA) is a heterogeneous disease which rheumatologists consider to be noninflammatory. However, recent studies suggest that, at least in certain patients, OA is an inflammatory disease and that patients often ... -
Detection of negative and positive RNA strand of poliovirus Sabin 1 and echovirus E19 by a stem-loop reverse transcription PCR
(2017)In this report a strand specific RT-PCR was established for the detection of the replicative negative RNA strand of poliovirus sabin 1 (Sabin1) and Echovirus 19 (E19) strains. The key for the successful conduction of the ... -
Diana-map: Analyzing mirna from raw ngs data to quantification
(2021)microRNAs (miRNAs) are small non-coding RNAs (~22 nts) that are considered central post-transcriptional regulators of gene expression and key components in many pathological conditions. Next-Generation Sequencing (NGS) ... -
DIANA-mirExTra v2.0: Uncovering microRNAs and transcription factors with crucial roles in NGS expression data
(2016)Differential expression analysis (DEA) is one of the main instruments utilized for revealing molecular mechanisms in pathological and physiological conditions. DIANA-mirExTra v2.0 (http://www.microrna. gr/mirextrav2) ... -
DIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions
(2015)microRNAs (miRNAs) are short non-coding RNA species, which act as potent gene expression regulators. Accurate identification of miRNA targets is crucial to understanding their function. Currently, hundreds of thousands of ... -
DiS-TSS: An Annotation Agnostic Algorithm for TSS Identification
(2020)The spread, distribution and utilization of transcription start sites (TSS) experimental evidence within promoters are poorly understood. Cap Analysis of Gene Expression (CAGE) has emerged as a popular gene expression ... -
Enhancing Clustering of Single-Cell RNA-Seq Data by Proximity Learning on Random Projected Spaces
(2019)We are in the era of single-cell RNA sequencing technology, which offers a great potential for uncovering cellular differences with a higher resolution, shedding light in various complex biological processes and complex ...