Sfoglia per Soggetto "MALIGNANT GLIOMA"
Items 1-4 di 4
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High intratumoural accumulation of stealth (R) liposomal doxorubicin (Caelyx (R)) in glioblastomas and in metastatic brain tumours
(2000)The blood-brain barrier is a major obstacle for the chemotherapeutic drugs to effectively reach primary or secondary brain tumours. Stealth(R) liposomal drugs are highly accumulated in tumoural tissues. In the present study ... -
MGMT repletion after treatment of glioblastoma cells with temozolomide and O6-benzylguanine implicates NF kappa B and mutant p53
(2013)The DNA repair enzyme O6-methylguanine methyltransferase (MGMT) is a major determinant of glioma resistance to alkylating agents. Several strategies have been used to induce sensitization to alkylator-based treatments, ... -
Prognostic Value of MRS Metabolites in Postoperative Irradiated High Grade Gliomas
(2015)Purpose. We studied the prognostic significance of Magnetic Resonance Spectroscopy (MRS) in operated high grade gliomas. Materials and Methods. Twelve patients were treated with radiotherapy and Temozolomide. The MRS data ... -
The role of ubiquitin-proteasome system in glioma survival and growth
(2013)High-grade gliomas represent a group of aggressive brain tumors with poor prognosis due to an inherent capacity of persistent cell growth and survival. The ubiquitin-proteasome system (UPS) is an intracellular machinery ...