Sfoglia per Soggetto "LINES"
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Additive enhancement of apoptosis by TRAIL and fenretinide in metastatic breast cancer cells in vitro
(2014)Successful management of metastatic breast cancer still needs better chemotherapeutic approaches. The combination of fenretinide (4-HPR), a synthetic retinoid inducing apoptosis by ROS generation, and TRAIL, a cell death ... -
MGMT repletion after treatment of glioblastoma cells with temozolomide and O6-benzylguanine implicates NF kappa B and mutant p53
(2013)The DNA repair enzyme O6-methylguanine methyltransferase (MGMT) is a major determinant of glioma resistance to alkylating agents. Several strategies have been used to induce sensitization to alkylator-based treatments, ... -
Neuroblastoma cells negative for CD44 possess tumor-initiating properties
(2011)CD44 has been linked to favorable prognosis in neuroblastoma and in the present study we investigate if it can be used to prospectively isolate neuroblastoma-initiating cells. To define the cancer-initiating properties of ... -
Optimal Control of Noncollaborative Servers in Two-Stage Tandem Queueing Systems
(2014)We consider two-stage tandem queueing systems with dedicated servers in each station and a flexible server that is trained to serve both stations. We assume no arrivals, exponential service times, and linear holding costs ... -
Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells
(2007)Several food polyphenols act as chemopreventers by reducing the incidence of many types of cancer, especially in colon epithelia. In this study, we have investigated whether the flavonoid quercetin can modulate cell ...