Sfoglia per Soggetto "FACTOR-I"
Items 1-7 di 7
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2-Oxoglutarate-dependent oxygenases control hepcidin gene expression
(2008)Background/Aims: Hepcidin is a liver-produced hormone that regulates systemic iron homeostasis. Hepcidin expression is stimulated upon iron overload or inflammation while iron deficiency, anemia and tissue hypoxia are ... -
Bortezomib represses HIF-1 alpha protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells
(2012)Bortezomib represents the first proteasome inhibitor (PI) with demonstrated antitumor activity in the clinical setting, particularly for treatment of hematological malignancies. At the preclinical level, its action is shown ... -
Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells
(2013)Hypoxia-inducible factors (HIFs) are transcriptional regulators that mediate the cellular response to low oxygen. Although HIF-1 is usually considered as the principal mediator of hypoxic adaptation, several tissues and ... -
eIF2 alpha Kinase PKR Modulates the Hypoxic Response by Stat3-Dependent Transcriptional Suppression of HIF-1 alpha
(2010)Hypoxia within the tumor microenvironment promotes angiogenesis, metabolic reprogramming, and tumor progression. In addition to activating hypoxia-inducible factor-1 alpha (HIF-1 alpha), cells also respond to hypoxia by ... -
Flavonoids induce HIF-1 alpha but impair its nuclear accumulation and activity
(2008)Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is the regulatory subunit of the transcription factor HIF-1, which is highly involved in the pathology of diseases associated with tissue hypoxia. In this study we investigated ... -
High serum levels of HIF-1 alpha in psoriatic patients correlate with an over-expression of IL-6
(2013)Angiogenesis has been considered to be an important step in the initiation and progression of chronic diseases such as psoriasis. The hypoxia inducible factor 1 alpha (HIF-1 alpha), a critical hypoxia-induced factor that ... -
Validated analysis of HIF-1 alpha expression in cancer cells using a controlled and comparative immunoassay
(2010)The immunoreactivity of hypoxia inducible factor 1 alpha (HIF-1 alpha) has been considered a reliable indicator of the HIF-1 pathway activation in tissue hypoxia. However, HIF-1 alpha immunoreactivity has been evaluated ...