Sfoglia per Autore "Liakopoulos, T. D."
Items 1-8 di 8
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Combined prediction of Tat and Sec signal peptides with hidden Markov models
Bagos, P. G.; Nikolaou, E. P.; Liakopoulos, T. D.; Tsirigos, K. D. (2010)Motivation: Computational prediction of signal peptides is of great importance in computational biology. In addition to the general secretory pathway ( Sec), Bacteria, Archaea and chloroplasts possess another major pathway ... -
CW-PRED: A HMM-based method for the classification of cell wall-anchored proteins of Gram-positive bacteria
Fimereli, D. K.; Tsirigos, K. D.; Litou, Z. I.; Liakopoulos, T. D.; Bagos, P. G.; Hamodrakas, S. J. (2012)Gram-positive bacteria have surface proteins that are often implicated in virulence. A group of extracellular proteins attached to the cell wall contains an LPXTG-like motif that is target for cleavage and covalent coupling ... -
ExTopoDB: a database of experimentally derived topological models of transmembrane proteins
Tsaousis, G. N.; Tsirigos, K. D.; Andrianou, X. D.; Liakopoulos, T. D.; Bagos, P. G.; Hamodrakas, S. J. (2010)ExTopoDB is a publicly accessible database of experimentally derived topological models of transmembrane proteins. It contains information collected from studies in the literature that report the use of biochemical methods ... -
Meta-Analysis of Family-Based and Case-Control Genetic Association Studies that Use the Same Cases
Bagos, P. G.; Dimou, N. L.; Liakopoulos, T. D.; Nikolopoulos, G. K. (2011)In many cases in genetic epidemiology, the investigators in an effort to control for different sources of confounding and simultaneously to increase the power perform a family-based and a population-based case-control study ... -
A Multipoint Method for Meta-Analysis of Genetic Association Studies
Bagos, P. G.; Liakopoulos, T. D. (2010)Meta-analyses of genetic association studies are usually performed using a single polymorphism at a time, even though in many cases the individual studies report results from partially overlapping sets of polymorphisms. ... -
Prediction of cell wall sorting signals in gram-positive bacteria with a hidden markov model: Application to complete genomes
Litou, Z. I.; Bagos, P. G.; Tsirigos, K. D.; Liakopoulos, T. D.; Hamodrakas, S. J. (2008)Surface proteins in Gram-positive bacteria are frequently implicated in virulence. We have focused on a group of extracellular cell wall-attached proteins (CWPs), containing an LPXTG motif for cleavage and covalent coupling ... -
Prediction of Lipoprotein Signal Peptides in Gram-Positive Bacteria with a Hidden Markov Model
Bagos, P. G.; Tslrigos, K. D.; Liakopoulos, T. D.; Hamodrakas, S. J. (2008)We present a Hidden Markov Model method for the prediction of lipoprotein signal peptides of Gram-positive bacteria, trained on a set of 67 experimentally verified lipoproteins. The method outperforms LipoP and the methods ... -
Prediction of signal peptides in archaea
Bagos, P. G.; Tsirigos, K. D.; Plessas, S. K.; Liakopoulos, T. D.; Hamodrakas, S. J. (2009)Computational prediction of signal peptides (SPs) and their cleavage sites is of great importance in computational biology; however, currently there is no available method capable of predicting reliably the SPs of archaea, ...