Parcourir par sujet "systems biology"
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Bipartite graphs in systems biology and medicine: A survey of methods and applications
(2018)The latest advances in high-throughput techniques during the past decade allowed the systems biology field to expand significantly. Today, the focus of biologists has shifted from the study of individual biological components ... -
Drug genetic associations with COVID-19 manifestations: a data mining and network biology approach
(2022)Available drugs have been used as an urgent attempt through clinical trials to minimize severe cases of hospitalizations with Coronavirus disease (COVID-19), however, there are limited data on common pharmacogenomics ... -
Epigenetic regulation of apoptosis via the PARK7 interactome in peripheral blood mononuclear cells donated by tuberculosis patients vs. healthy controls and the response to treatment: A systems biology approach
(2020)Aims: The aims of our study were to determine for the first time differentially expressed genes (DEGs) and enriched molecular pathways involving the PARK7 interactome in PBMCs donated from tuberculosis patients. Methods: ... -
GOrevenge: A Novel Generic Reverse Engineering Method for the Identification of Critical Molecular Players, Through the Use of Ontologies
(2011)The ever-increasing use of ontologies in modern biological analysis and interpretation facilitates the understanding of the cellular procedures, their hierarchical organization, and their potential interactions at a system's ... -
Identification of neoplasm-specific signatures of miRNA interactions by employing a systems biology approach
(2022)MicroRNAs represent major regulatory components of the disease epigenome and they constitute powerful biomarkers for the accurate diagnosis and prognosis of various diseases, including cancers. The advent of high-throughput ... -
Network analysis of genes and their association with diseases
(2016)A plethora of network-based approaches within the Systems Biology universe have been applied, to date, to investigate the underlying molecular mechanisms of various human diseases. In the present study, we perform a ... -
Overlapping host pathways between SARS-CoV-2 and its potential copathogens: An in silico analysis
(2020)Background: SARS-CoV-2 coinfection with other viral and bacterial pathogens and their interactions are increasingly recognized in the literature as potential determinants of COVID-19 phenotypes. The aim of this study was ... -
Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration
(2011)Vitamin D has been shown to have anti-angiogenic properties and to play a protective role in several types of cancer, including breast, prostate and cutaneous melanoma. Similarly, vitamin D levels have been shown to be ...