Parcourir par sujet "protein folding"

Dual IRE1 RNase functions dictate glioblastoma development

Lhomond S., Avril T., Dejeans N., Voutetakis K., Doultsinos D., McMahon M., Pineau R., Obacz J., Papadodima O., Jouan F., Bourien H., Logotheti M., Jégou G., Pallares-Lupon N., Schmit K., Le Reste P.-J., Etcheverry A., Mosser J., Barroso K., Vauléon E., Maurel M., Samali A., Patterson J.B., Pluquet O., Hetz C., Quillien V., Chatziioannou A., Chevet E. (2018)

Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical ...

Low complexity regions in the proteins of prokaryotes perform important functional roles and are highly conserved

Ntountoumi C., Vlastaridis P., Mossialos D., Stathopoulos C., Iliopoulos I., Promponas V., Oliver S.G., Amoutzias G.D. (2019)

We provide the first high-throughput analysis of the properties and functional role of Low Complexity Regions (LCRs) in more than 1500 prokaryotic and phage proteomes. We observe that, contrary to a widespread belief based ...

Mitochondrial dynamics and proteins related to neurodegenerative diseases

Alexiou A., Nizami B., Khan F.I., Soursou G., Vairaktarakis C., Chatzichronis S., Tsiamis V., Manztavinos V., Yarla N.S., Md Ashraf G. (2018)

Disruptions in the regulation of mitochondrial dynamics and the occurrence of proteins misfolding lead to neuronal death, resulting in Age-related Dementia and Neurodegenerative diseases as well as Frailty. Functional, ...

Optimization of Recombinant Membrane Protein Production in the Engineered Escherichia coli Strains SuptoxD and SuptoxR

Michou M., Kapsalis C., Pliotas C., Skretas G. (2019)

Membrane proteins (MPs) execute a wide variety of critical biological functions in all living organisms and constitute approximately half of current targets for drug discovery. As in the case of soluble proteins, the ...

Role of Arc1p in the modulation of yeast glutamyl-tRNA synthetase activity

Graindorge, J. S.; Senger, B.; Tritch, D.; Simos, G.; Fasiolo, F. (2005)

Yeast methionyl-tRNA synthetase (MetRS) and glutamyl-tRNA synthetase (GluRS) possess N-terminal extensions that bind the cofactor Arc1p in trans. The strength of GluRS-Arc1p interaction is high enough to allow copurification ...

SuptoxD2.0: A second-generation engineered Escherichia coli strain achieving further enhanced levels of recombinant membrane protein production

Michou M., Stergios A., Skretas G. (2020)

The bacterium Escherichia coli is among the most popular hosts for recombinant protein production, including that of membrane proteins (MPs). We have recently generated the specialized MP-producing E. coli strain SuptoxD, ...

We are what we eat: Ubiquitin–proteasome system (UPS) modulation through dietary products

Panagiotidou E., Chondrogianni N. (2020)

During lifetime, the molecular mechanisms that are responsible for cellular defense against adverse conditions such as oxidative and heat stress tend to be less efficient, thus gradually leading to the natural phenomenon ...