Parcourir par sujet "TRANSCRIPTIONAL ACTIVITY"
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Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1 alpha by MAPK
(2008)Hypoxia-inducible factor 1 (HIF-1) is the key transcriptional activator of hypoxia-inducible genes and an important anti-cancer target. Its regulated subunit, HIF-1 alpha, is controlled by oxygen levels and major signaling ... -
Bortezomib represses HIF-1 alpha protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells
(2012)Bortezomib represents the first proteasome inhibitor (PI) with demonstrated antitumor activity in the clinical setting, particularly for treatment of hematological malignancies. At the preclinical level, its action is shown ... -
CK1 delta restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1 alpha/ARNT complex formation
(2015)Proliferation of cells under hypoxia is facilitated by metabolic adaptation, mediated by the transcriptional activator Hypoxia Inducible Factor-1 (HIF-1). HIF-1 alpha, the inducible subunit of HIF-1 is regulated by oxygen ... -
The flavonoid quercetin induces hypoxia-inducible factor-1 alpha (HIF-1 alpha) and inhibits cell proliferation by depleting intracellular iron
(2007)Quercetin, a flavonoid with anti- oxidant, metal chelating, kinase modulating and anti- proliferative properties, can induce hypoxia- inducible factor-1 alpha (HIF-1 alpha) in normoxia, but its mechanism of action has not ... -
Syncytins expression in cultured trophoblast cells according to differentiation status
(2011)Background: Data of syncytin 1 and 2 env gene expression in human placenta and participation in the syncytialisation phenomena has been reported. However, there are not many studies on simultaneous changes in expression ...