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Anesthetic Ketamine Impairs Rats' Recall of Previous Information The Nitric Oxide Synthase Inhibitor N-nitro-L-arginine Methylester Antagonizes This Ketamine-induced Recognition Memory Deficit
(2011)Background: There is poor experimental evidence concerning the effects of anesthetic doses of the noncompetitive N-methyl-D-aspartate receptor antagonist ketamine on rodents' memory abilities. The current study was designed ... -
Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo
(2011)Anti-cancer effects of a newly-synthesized palladium(II) complex, [Pd(sac)(terpy)](sac)center dot 4H(2)O (sac = saccharinate, and terpy = 2,2':6',2 ''-terpyridine), were tested against human breast cancer cell lines, MCF-7 ... -
Association of KLOTHO Gene Polymorphisms with Knee Osteoarthritis in Greek Population
(2008)Based on the fact that klotho-deficient mice exhibit multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints and on the recent observation that KLOTHO gene plays an important role in calcium/phosphate ... -
A comparison of tests for restricted orderings in the three-class case
(2009)A variety of methods for comparing three distributions have been proposed in the literature. These methods assess the same null hypothesis of equal distributions but differ in the alternative hypothesis they consider. The ... -
Correlation of estrogen receptor beta gene polymorphisms with spinal bone mineral density in peri- and post-menopausal Greek women
(2006)Estrogens play a significant role in bone physiology. Their action is mainly exerted through their receptors. Estrogen receptor alpha (ER alpha) plays a major role in bone homeostasis and there is evidence suggesting that ... -
Cytokine levels in the sera of patients with idiopathic pulmonary fibrosis
(2006)Background: Idiopathic pulmonary fibrosis (IPF) is a fibroprotiferative disorder. Cytokines contribute an important but yet undefined role to its pathogenesis. Objectives: The present study aims to compare serum levels of ... -
Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus
(2011)Objective: The common single nucleotide polymorphism (SNP) rs143383 in the 5' untranslated region (5'UTR) of growth and differentiation factor 5 (GDF5) is strongly associated with osteoarthritis (OA) and influences GDF5 ... -
Dose Escalation of Amifostine for Radioprotection During Pelvic Accelerated Radiotherapy
(2013)Objectives: Experimental data suggest a dose-dependent efficacy of amifostine so that the low overall doses used in clinical trials may have masked the full potential of the drug. In this study, we report our experience ... -
Effects of sub-anesthetic doses of ketamine on rats' spatial and non-spatial recognition memory
(2008)There are experimental evidences indicating that the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist ketamine impairs cognition and produces a series of schizophrenia-like symptoms in rodents (hyperactivity, ... -
Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety
(2008)Crocus sativus L. is a plant cultivated in various parts of the world. Crocins are among the active components of Crocus sativus L. The present study was designed to investigate in the rat whether or not crocins possess ... -
Effects of the active constituents of Crocus Sativus L., crocins, in an animal model of obsessive-compulsive disorder
(2012)Crocins are among the active components of the plant Crocus Sativus L C. Sativus L and its constituents were effective in different models of psychiatric disorders including anxiety and depression. Obsessive-compulsive ... -
Ferroportin in monocytes of hemodialysis patients and its associations with hepcidin, inflammation, markers of iron status and resistance to erythropoietin
(2014)Disturbed iron homeostasis contributes to resistance to recombinant human erythropoietin (rHuEpo) in hemodialysis (HD) patients. Increased hepcidin, which downregulates the iron exporter ferroportin, has been incriminated. ... -
A Foamy Virus Vector System for Stable and Efficient RNAi Expression in Mammalian Cells
(2011)The promise of the RNA interference (RNAi) technology is equally dependent on the efficiency and stability of gene silencing. The aim of the present study was the development of foamy virus (FV) vectors for stable RNAi, ... -
Grape pomace extract exerts antioxidant effects through an increase in GCS levels and GST activity in muscle and endothelial cells
(2015)In a previous study, we demonstrated that a grape pomace extract (GPE) exerted antioxidant activity in endothelial (EA. hy926) and muscle (C2C12) cells through an increase in glutathione (GSH) levels. In the present study, ... -
Heterozygous Alterations of TNFRSF13B/TACI in Tonsillar Hypertrophy and Sarcoidosis
(2013)TNFRSF13B/TACI defects have been associated with CVID pathogenesis and/or phenotype, especially the development of benign lymphoproliferation and autoimmunity. Our purpose was to investigate the role of TNFRSF13B/TACI ... -
High nitrate content in drinking water: Cytogenetic effects in exposed children
(1996)The potential genotoxicity of nitrates and nitrites-contaminants of drinking water that have been implicated in carcinogenesis-was investigated in this study. Sister chromatid exchanges and frequency of chromatid/chromosome ... -
Immunomodulatory effects of dietary protein during Nippostrongylus brasiliensis re-infection in lactating rats
(2009)Periparturient relaxation of immunity (PPRI) to secondary infection with nematodes is believed to have a nutritional basis due to differential partitioning of scarce nutrient resources, particularly protein, to reproductive ... -
The metabotropic glutamate 2/3 receptor antagonist LY341495 differentially affects recognition memory in rats
(2012)Experimental evidence suggests that metabotropic glutamate 2/3 (mGlu2/3) receptor antagonists affect cognitive function, although contradictory findings have been reported. To clarify the role of mGlu2/3 receptor antagonists ...