Parcourir par sujet "Fluorouracil"
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Haplotype structure defines effects of common DPYD variants c.85T > C (rs1801265) and c.496A > G (rs2297595) on dihydropyrimidine dehydrogenase activity: Implication for 5-fluorouracil toxicity
(2021)Aims: The aim of this study was to identify risk variants and haplotypes that impair dihydropyrimidine dehydrogenase (DPD) activity and are, therefore, candidate risk variants for severe toxicity to 5-fluorouracil (5-FU) ... -
New short route to unsaturated fluoroketonucleosides: Case of 5-fluoro-1-(6-0-acetyl-3,4-di-deoxy-3-fluoro-β-D-glycero-hex-3-eno-pyranos- 2-ulosyl) uracil
(2005)The proposed short synthesis involves two key steps: Oxidation of the isopropylidene derivative of the 3-fluoronucleoside possessing a free hydroxyl group in 2-position and acetylation of deprotected 3-fluoro-2-ketonucleoside ...