Parcourir par sujet "CARCINOMA"
Voici les éléments 1-20 de 40
-
Angiogenesis and apoptosis-related protein (p53, bcl-2, and bax) expression versus response of gastric adenocarcinomas to paclitaxel and carboplatin chemotherapy
(2001)The role of angiogenesis and apoptosis-related proteins in defining response to chemotherapy is poorly understood. We examined the microvessel density (MVD) and the expression of p53, bcl-2, and bax proteins in a series ... -
Angiogenesis, thymidine phosphorylase, and resistance of squamous cell head and neck cancer to cytotoxic and radiation therapy
(2000)Thymidine phosphorylase (TP), an enzyme involved in the thymidine synthesis and degradation, has been shown to promote tumor angiogenesis, Both TP expression and tumor vascularization are putative postoperative prognostic ... -
Angiogenic interactions of vascular endothelial growth factor, of thymidine phosphorylase, and of p53 protein expression in locally advanced gastric cancer
(2000)The assessment of the angiogenic profile of tumors may become an important tool as a guide for the inclusion of novel drugs and molecular therapies into the standard chemoradiotherapy policy. Several studies have shown the ... -
bcl-2 and c-erbB-2 proteins are involved in the regulation of VEGF and of thymidine phosphorylase angiogenic activity in non-small-cell lung cancer
(1999)Tumour angiogenesis has been recently recognised as one of the most important prognostic factors in lung cancer. Although a variety of angiogenic factors have been identified, the angiogenesis process remains poorly ... -
Changing pattern of cytokeratin 7 and 20 expression from normal epithelium to intestinal metaplasia of the gastric mucosa and gastroesophageal junction
(2002)It is currently unclear whether intestinal metaplasia at the esophagogastric junction and in the distal esophagus represent a continuum of the same underlying disease process, i.e., gastroesophageal reflux, or constitute ... -
CHARACTERIZATION OF THE PROTEIN PROTECTING RNA FROM ACID PRECIPITATION AND ITS EVALUATION AS TUMOR-MARKER IN GASTROINTESTINAL AND GYNECOLOGICAL CANCER
(1995)In a previous study, we observed increased protective activity against acid precipitation of poly (U) in the serum of tumor bearing mice and hepatoma patients. In the present study we purified and partially characterized ... -
Chromogenic in situ Hybridization Analysis of EGFR Gene Copies in Colon Adenocarcinoma Based on Intra-Operative Imprints and Tissue Microarrays
(2009)Background: Although Epidermal Growth Factor Receptor (EGFR) over expression is a frequent event in colon adenocarcinoma (CA), identification of EGFR gene deregulation mechanisms - combined to k-ras mutations - remains the ... -
Clinical and experimental evidence of bcl-2 involvement in the response to photodynamic therapy
(2001)Purpose: The role of apoptosis related proteins in the response of human malignancies to photodynamic therapy (PDT) is under investigation. The aim of the study was to examine the role of p53 and of bcl-2 protein expression ... -
Detection of microsatellite instability in sporadic cardiac myxomas
(1999)Objective: Microsatellite instability (MIN) is an early event in DNA repair-deficient associated diseases and reflects an elevated mutation rate in the genome of neoplastic cells. Sporadic cardiac myxomas are the most ... -
Determination of human papillomavirus 16 physical status through E1/E6 and E2/E6 ratio analysis
(2014)Human papillomavirus (HPV) 16 genome integration into the host chromosome is a crucial event during the life cycle of the virus and a major step towards carcinogenesis. The integration of HPV16 DNA promotes a constitutive ... -
Effects of melatonin on proliferation of cancer cell lines
(1998)The pineal hormone melatonin has been reported to have in vitro antiproliferative effects on estrogen receptor-positive human breast cancer cell lines at concentrations near to plasma physiological concentrations (1 x ... -
Enzyme-linked immunosorbent assay for pharmacological studies targeting hypoxia-inducible factor 1 alpha
(2005)Hypoxia-inducible factor 1 (HIF-1) activates the transcription of a wide range of genes related to oxygen delivery and metabolic adaptation under hypoxic (low-oxygen) conditions. HIF-1 is, in fact, a heterodimer of two ... -
Evaluation of Current Prognostic and Predictive Markers in Breast Cancer: A Validation Study of Tissue Microarrays
(2013)Background: Tissue microarrays (TMAs) are an attractive alternative to analysis of whole sections (WS). For breast carcinomas, the recent recommendations for cut-offs (i.e. Ki67, H-score) have necessitated the re-evaluation ... -
The Fat Content of Small Primary Breast Cancer Interferes with Radiofrequency-Induced Thermal Ablation
(2009)Background: Radiofrequency (RF) thermal ablation is a minimally invasive technique of local mass elimination with variable efficiency. Methods: Ten patients with small primary breast cancer diagnosed preoperatively by core ... -
FDG-PET for detecting local tumor recurrence of ablated liver metastases: a diagnostic meta-analysis
(2012)Context: Scanty reports have focused on FDG-PET after radiofrequency ablation (RFA), for recurrence of hepatic metastases. Objective: To assess FDG-PET diagnostic accuracy on detection of recurrent hepatic lesions. Methods: ... -
Feasibility and safety of radical cystectomy under combined spinal and epidural anesthesia in octogenarian patients with ASA score >= 3: A case series
(2015)Introduction: This study evaluated the feasibility and safety of open radical cystectomy (RC) under combined regional anesthesia (CRA) in high-risk octogenarian patients. Methods: We retrospectively evaluated the medical ... -
Foxp3 expression in human cancer cells
(2008)Objective: Transcription factor forkhead box protein 3 (Foxp3) specifically characterizes the thymically derived naturally occurring regulatory T cells (Tregs). Limited evidence indicates that it is also expressed, albeit ... -
Importance of high-performance liquid chromatographic analysis of serum N-acylneuraminic acids in evaluating surgical treatment in patients with early endometrial cancer
(1999)The objectives of this study were the quantification of the two major sialic acid (Sia) forms - N-acetylneuraminic (Neu5Ac) and N-glycolylneuraminic acids (Neu5Gc) - in serum before and after surgical treatment of early ... -
Intraoperative radiation therapy on pancreatic cancer patients: a review of the literature
(2011)Pancreatic cancer is rarely curable, and the overall survival rate at 5 years is under 4%. This study aimed to assess the efficacy, effectiveness and safety of intraoperative radiation therapy (IORT) as treatment in ... -
Intraperitoneal Dissemination of Endometrial Cancer Cells After Hysteroscopy A Systematic Review and Meta-Analysis
(2010)Introduction: Hysteroscopy is a diagnostic procedure with a high accuracy in diagnosing endometrial cancer. Because of the increase of intrauterine pressure during distention media inflation, several retrospective studies ...