Parcourir par sujet "B-Lymphocytes"
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Alpha-actinin: A multidisciplinary protein with important role in B-cell driven autoimmunity
(2011)Alpha-actinin (α-actinin) is a ubiquitous cytoskeletal protein, which belongs to the superfamily of filamentous actin (F-actin) crosslinking proteins. It is present in multiple subcellular regions of both muscle and ... -
B Cells and COVID-19: Lessons From Patients With Agammaglobulinemia and the Study of Functional B-Cell Polymorphisms
(2022)[No abstract available] -
BAFF receptor polymorphisms and deficiency in humans
(2021)The BAFF-receptor (BAFFR) is a member of the TNF-receptor family. It is expressed only by B cells and binds BAFF as single ligand, which activates key signaling pathways regulating essential cellular functions, including ... -
Crystalline silica activates the T-cell and the B-cell antigen receptor complexes and induces T-cell and B-cell proliferation
(2019)Silicosis is an occupational fibrotic lung disease, which is associated with an increased incidence of autoimmune diseases. The effect of crystalline silica on the immune system is thought to be mediated by the antigen ... -
The effect of hexanic extract of Serenoa repens on prostatic inflammation: results from a randomized biopsy study
(2019)Purpose: To evaluate the effect of hexanic extract of Serenoa repens (HESr) on prostatic inflammation in patients with diagnosed prostatic inflammation. Methods: Patients with prostatic inflammation histologically confirmed ... -
Interleukin 21 controls mRNAand MicroRNA expression in CD40-activated chronic lymphocytic leukemia cells
(2015)Several factors support CLL cell survival in the microenvironment. Under different experimental conditions, IL21 can either induce apoptosis or promote CLL cell survival. To investigate mechanisms involved in the effects ... -
Lymph Node Cellular Dynamics in Cancer and HIV: What Can We Learn for the Follicular CD4 (Tfh) Cells?
(2018)Lymph nodes (LNs) are central in the generation of adaptive immune responses. Follicular helper CD4 T (Tfh) cells, a highly differentiated CD4 population, provide critical help for the development of antigen-specific B ... -
A multicenter, open-label, comparative study of B-cell depletion therapy with Rituximab for systemic sclerosis-associated interstitial lung disease
(2017)Objectives Rituximab (RTX) may favorably affect lung function and skin fibrosis in patients with systemic sclerosis (SSc). We aimed to assess long-term efficacy and safety of RTX in SSc compared to standard treatment. ... -
Pathogenetic Aspects of Systemic Sclerosis: A View Through the Prism of B Cells
(2022)Systemic sclerosis (SSc) is a rare fibrotic rheumatic disease, associated with psychological distress and increased morbidity and mortality due to skin involvement and internal organ damage. The current understanding of ... -
The role of B cells in the pathogenesis of systemic sclerosis
(2016)Systemic sclerosis (SSc) is characterized by extensive collagen deposition, microvasculopathy and autoantibodies. All three features can be promoted by activation of T cells and B cells. T cells are of Th2 type producing ... -
The role of Dickkopf-1 in joint remodeling and fibrosis: A link connecting spondyloarthropathies and scleroderma?
(2017)Background Dickkopf-1 (Dkk-1) is a soluble inhibitor of the canonical Wnt pathway, which plays critical roles in embryonic development. Evidence suggests that this molecule regulates several aspects of both bone biology ... -
The role of invariant NKT in autoimmune liver disease: Can Vitamin D Act as an Immunomodulator?
(2018)Natural killer T (NKT) cells are a distinct lineage of T cells which express both the T cell receptor (TCR) and natural killer (NK) cell markers. Invariant NKT (iNKT) cells bear an invariant TCR and recognize a small variety ... -
The role of platelets in autoimmunity, vasculopathy, and fibrosis: Implications for systemic sclerosis
(2017)Introduction Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, autoimmunity, and widespread dermal and visceral fibrosis. This article summarizes the current knowledge about the potential ... -
Systemic sclerosis: New evidence re-enforces the role of B cells
(2016)Systemic sclerosis (SSc) is characterized by widespread fibrosis, microangiopathy (vasospasms and stenosis), and formation of autoantibodies. T cell activation has been shown to contribute to fibrosis and microvasculopathy ... -
Taci mutations in primary antibody deficiencies: A nationwide study in greece
(2021)Background and objectives: Monoallelic (heterozygous) or biallelic (homozygous or com-pound heterozygous) TACI mutations have been reported as the most common genetic defects in patients with common variable immunodeficiency ... -
TNFRSF13C/BAFFR P21R and H159Y polymorphisms in multiple sclerosis
(2020)Recent studies implicate B cells in multiple sclerosis (MS) pathogenesis, and consequently, several molecules participating in B cell survival and proliferation, including B-cell activating factor (BAFF), have recently ... -
Urate crystals trigger B-cell receptor signal transduction and induce B-cell proliferation
(2020)Urate in its crystal form is a known danger-associated molecular pattern, which after its internalization activates cells of the innate immune system. However, by inducing lipid raft sequestration and clustering of ...