Parcourir par auteur "Voutsadakis, I. A."
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Bortezomib reverses the proliferative and antiapoptotic effect of neuropeptides on prostate cancer cells
Tsapakidis, K.; Vlachostergios, P. J.; Voutsadakis, I. A.; Befani, C. D.; Patrikidou, A.; Hatzidaki, E.; Daliani, D. D.; Moutzouris, G.; Liakos, P.; Papandreou, C. N. (2012)Objectives: Neuropeptides are important signal initiators in advanced prostate cancer, partially acting through activation of nuclear factor kappa B. Central to nuclear factor kappa B regulation is the ubiquitin-proteasome ... -
CD10 Is Inversely Associated with Nuclear Factor-Kappa B and Predicts Biochemical Recurrence after Radical Prostatectomy
Voutsadakis, I. A.; Vlachostergios, P. J.; Daliani, D. D.; Karasavvidou, F.; Kakkas, G.; Moutzouris, G.; Melekos, M. D.; Papandreou, C. N. (2012)Introduction: The cell surface endopeptidase CD10 (neutral endopeptidase) and nuclear factor-kappa B (NF-kappa B) have been independently associated with prostate cancer (PC) progression. We investigated the correlations ... -
Mechanisms of proteasome inhibitor-induced cytotoxicity in malignant glioma
Vlachostergios, P. J.; Voutsadakis, I. A.; Papandreou, C. N. (2013)The 26S proteasome constitutes an essential degradation apparatus involved in the consistent recycling of misfolded and damaged proteins inside cells. The aberrant activation of the proteasome has been widely observed in ... -
NEUTRAL ENDOPEPTIDASE (NEP) AND ENDOTHELIN 1 (ET-1) ARE INVERSELY EXPRESSED IN HORMONE-NAIVE PROSTATE CANCER AND ARE PREDICTORS OF BIOCHEMICAL FAILURE FROM RADICAL PROSTATECTOMY
Vlachostergios, P. J.; Patrikidou, A.; Kakkas, G.; Moutzouris, G.; Voutsadakis, I. A.; Karasavvidou, F.; Daliani, D. D.; Koukoulis, G.; Melekos, M. D.; Papandreou, C. N. (2010) -
p53 and Cyclooxygenase-2 Expression are Directly Associated with Cyclin D1 Expression in Radical Prostatectomy Specimens of Patients with Hormone-Naive Prostate Cancer
Vlachostergios, P. J.; Karasavvidou, F.; Patrikidou, A.; Voutsadakis, I. A.; Kakkas, G.; Moutzouris, G.; Zintzaras, E.; Daliani, D. D.; Melekos, M. D.; Papandreou, C. N. (2012)Prostate cancer (PCa) is a potentially curable disease when diagnosed in early stages and subsequently treated with radical prostatectomy (RP). However, a significant proportion of patients tend to relapse early, with the ... -
The role of ubiquitin-proteasome system in glioma survival and growth
Vlachostergios, P. J.; Voutsadakis, I. A.; Papandreou, C. N. (2013)High-grade gliomas represent a group of aggressive brain tumors with poor prognosis due to an inherent capacity of persistent cell growth and survival. The ubiquitin-proteasome system (UPS) is an intracellular machinery ... -
The shaping of invasive glioma phenotype by the ubiquitin-proteasome system
Vlachostergios, P. J.; Voutsadakis, I. A.; Papandreou, C. N. (2013)Protein degradation is an indispensable process for cells which is often deregulated in various diseases, including malignant conditions. Depending on the specific cell type and functions of expressed proteins, this ... -
The ubiquitin-proteasome system in glioma cell cycle control
Vlachostergios, P. J.; Voutsadakis, I. A.; Papandreou, C. N. (2012)A major determinant of cell fate is regulation of cell cycle. Tight regulation of this process is lost during the course of development and progression of various tumors. The ubiquitin-proteasome system (UPS) constitutes ...