Parcourir par auteur "Tsirkone, V. G."
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1-(3-Deoxy-3-fluoro-beta-D-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies
Tsirkone, V. G.; Tsoukala, E.; Lamprakis, C.; Manta, S.; Hayes, J. M.; Skamnaki, V. T.; Drakou, C.; Zographos, S. E.; Komiotis, D.; Leonidas, D. D. (2010)Design of inhibitors of glycogen phosphorylase (GP) with pharmaceutical applications in improving glycaemic control in type 2 diabetes is a promising therapeutic strategy. The catalytic site of muscle glycogen phosphorylase ... -
Inhibitor design for ribonuclease A: the binding of two 5 '-phosphate uridine analogues
Tsirkone, V. G.; Dossi, K.; Drakou, C.; Zographos, S. E.; Kontou, M.; Leonidas, D. D. (2009)In the quest for the rational design of selective and potent inhibitors for members of the pancreatic ribonuclease A (RNase A) family of biomedical interest, the binding of uridine 5'-phosphate (U5P) and uridine 5'-diphosphate ... -
Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-beta-D-glucopyranosylamines
Parmenopoulou, V.; Kantsadi, A. L.; Tsirkone, V. G.; Chatzileontiadou, D. S. M.; Manta, S.; Zographos, S. E.; Molfeta, C.; Archontis, G.; Agius, L.; Hayes, J. M.; Leonidas, D. D.; Komiotis, D. (2014)Glycogen phosphorylase (GP) is a validated target for the development of new type 2 diabetes treatments. Exploiting the Zinc docking database, we report the in silico screening of 1888 N-acyl-beta-D-glucopyranosylamines ...