Parcourir par auteur "Tienari, P. J."
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Association of tau haplotype-tagging polymorphisms with Parkinson's disease in diverse ethnic Parkinson's disease cohorts
Fung, H. C.; Xiromerisiou, G.; Gibbs, J. R.; Wu, Y. R.; Eerola, J.; Gourbali, V.; Hellstrom, O.; Chen, C. M.; Duckworth, J.; Papadimitriou, A.; Tienari, P. J.; Hadjigeorgiou, G. M.; Hardy, J.; Singleton, A. B. (2006)Background: The overlap in the clinical and pathological features of tauopathies and synucleinopathies raises the possibility that the tau protein may be important in Parkinson's disease (PD) pathogenesis. Several MAPT ... -
BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson's disease in diverse ethnic groups
Xiromerisiou, G.; Hadjigeorgiou, G. M.; Eerola, J.; Fernandez, H. H.; Tsimourtou, V.; Mandel, R.; Hellstrom, O.; Gwinn-Hardy, K.; Okun, M. S.; Tienari, P. J.; Singleton, A. B. (2007)Experimental and clinical data suggest that genetic variations in brain-derived neurotrophic factor (BDNF) gene may affect risk for Parkinson's disease (PD). We performed a case-control association analysis of BDNF in three ... -
The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations
Scholz, S. W.; Xiromerisiou, G.; Fung, H. C.; Eerola, J.; Hellstrom, O.; Papadimitriou, A.; Hadjigeorgiou, G. M.; Tienari, P. J.; Fernandez, H. H.; Mandel, R.; Okun, M. S.; Gwinn-Hardy, K.; Singleton, A. B. (2006)Coexistence of prion disease and idiopathic Parkinson's disease (TPD) has been previously described. It remains unclear whether this relationship may reflect the high incidence of IPD or whether both prion and IPD share ... -
Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients
Clarimon, J.; Xiromerisiou, G.; Eerola, J.; Gourbali, V.; Hellstrom, O.; Dardiotis, E.; Peuralinna, T.; Papadimitriou, A.; Hadjigeorgiou, G. M.; Tienari, P. J.; Singleton, A. B. (2005)Background: Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic ... -
Testing association between LRRK2 and Parkinson's disease and investigating linkage disequilibrium
Paisan-Ruiz, C.; Evans, E. W.; Jain, S.; Xiromerisiou, G.; Gibbs, J. R.; Eerola, J.; Gourbali, V.; Hellstrom, O.; Duckworth, J.; Papadimitriou, A.; Tienari, P. J.; Hadjigeorgiou, G. M.; Singleton, A. B. (2006)Background: We and others recently identified the gene underlying PARK8 linked Parkinson's disease (PD). This gene, LRRK2, contains mutations that cause an autosomal dominant PD, including a mutation, G2019S, which is the ...