Parcourir par auteur "Stamatiou, R."
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Azithromycin has an antiproliferative and autophagic effect on airway smooth muscle cells
Stamatiou, R.; Paraskeva, E.; Boukas, K.; Gourgoulianis, K. I.; Molyvdas, P. A.; Hatziefthimiou, A. A. (2009)Azithromycin is used in long-term, low-dose treatment of airway diseases where airway wall remodelling is present. Since it improves total score symptom and respiratory function of such patients, we hypothesise that ... -
Azithromycin reduces the viability of human bronchial smooth muscle cells
Stamatiou, R.; Boukas, K.; Paraskeva, E.; Molyvdas, P. A.; Hatziefthimiou, A. (2010)The macrolide antibiotic azithromycin has an antiproliferative and autophagic effect on rabbit tracheal smooth muscle cells (SMCs). The purpose of this study is to investigate the effect of azithromycin on human bronchial ... -
Long-term exposure to muscarinic agonists decreases expression of contractile proteins and responsiveness of rabbit tracheal smooth muscle cells
Stamatiou, R.; Paraskeva, E.; Vasilaki, A.; Mylonis, I.; Molyvdas, P. A.; Gourgoulianis, K.; Hatziefthimiou, A. (2014)Background: Chronic airway diseases, like asthma or COPD, are characterized by excessive acetylcholine release and airway remodeling. The aim of this study was to investigate the long-term effect of muscarinic agonists on ... -
The mitogenic effect of testosterone and 17 beta-estradiol on airway smooth muscle cells
Stamatiou, R.; Paraskeva, E.; Papagianni, M.; Molyvdas, P. A.; Hatziefthimiou, A. (2011)Airway disease distribution and/or severity exhibit sex differences suggesting that sex hormones are involved in the respiratory system physiology and pathophysiology. The implication of airway smooth muscle cells (ASMCs) ... -
TNF alpha induces expression of HIF-1 mRNA and protein but inhibits hypoxic stimulation of HIF-1 alpha transcriptional activity in airway smooth muscle cells
Tsapournioti, S.; Mylonis, I.; Hatziefthimiou, A.; Ioannou, M. G.; Stamatiou, R.; Koukoulis, G. K.; Simos, G.; Molyvdas, P. A.; Paraskeva, E. (2013)Airway smooth muscle cells (ASMCs) participate in tissue remodeling characteristic of airway inflammatory diseases like asthma. Inflammation and hypoxia pathways are often interconnected and the regulatory subunit of the ...