Parcourir par auteur "Papavassiliou, A. G."
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Low levels of p27 in association with deregulated p53-pRb protein status enhance tumor proliferation and chromosomal instability in non-small cell lung carcinomas
Tsoli, E.; Gorgoulis, V. G.; Zacharatos, P.; Kotsinas, A.; Mariatos, G.; Kastrinakis, N. G.; Kokotas, S.; Kanavaros, P.; Asimacopoulos, P.; Bramis, J.; Kletsas, D.; Papavassiliou, A. G.; Kittas, C. (2001)Background: Down-regulation or overexpression of the cyclin-dependent kinase inhibitor p27 have been observed in a range of malignancies, including lung cancer. To further elucidate the role of the molecule in tumor growth ... -
Molecular Pathogenesis of Non Muscle-Invasive Bladder Cancer: Implications for Novel Targeted Therapies
Zachos, I.; Tzortzis, V.; Konstantinopoulos, P. A.; Karatzas, A.; Gravas, S.; Melekos, M.; Papavassiliou, A. G. (2011)Approximately 70% to 80% of patients with urothelial carcinomas of the bladder are initially diagnosed with non-muscle invasive disease. Superficial, non-muscle invasive bladder cancers (NMIBCs) are managed with cystoscopic ... -
Predictive value of telomerase reverse transcriptase expression in patients with high risk superficial bladder cancer treated with adjuvant BCG immunotherapy
Zachos, I.; Konstantinopoulos, P. A.; Vandoros, G. P.; Karamouzis, M. V.; Papatsoris, A. G.; Podimatas, T.; Papachristodoulou, A.; Chrisofos, M.; Deliveliotis, C.; Papavassiliou, A. G. (2009)We conducted a prospective study to determine whether expression of telomerase reverse transcriptase (hTERT) is associated with recurrence-free-survival (RFS) or development of invasive disease in patients with high risk ... -
Previous Bladder Cancer History in Patients with High-Risk, Non-muscle-invasive Bladder Cancer Correlates with Recurrence and Progression: Implications of Natural History
Mitrakas, L. P.; Zachos, I. V.; Tzortzis, V. P.; Gravas, S. A.; Rouka, E. C.; Dimitropoulos, K. I.; Vandoros, G. P.; Karatzas, A. D.; Melekos, M. D.; Papavassiliou, A. G. (2015)Purpose The purpose of this study was to assess the correlation of previous bladder cancer history with the recurrence and progression of patients with high-risk non-muscle-invasive bladder cancer treated with adjuvant ... -
Systemic therapy of metastatic bladder cancer in the molecular era: current status and future promise
Zachos, I.; Konstantinopoulos, P. A.; Tzortzis, V.; Gravas, S.; Karatzas, A.; Karamouzis, M. V.; Melekos, M.; Papavassiliou, A. G. (2010)Importance of the field: Platinum-based chemotherapy is considered the standard-of-care first-line therapy for metastatic bladder cancer. Despite the initial high response rate, the vast majority of patients eventually ... -
Tumor size and T stage correlate independently with recurrence and progression in high-risk non-muscle-invasive bladder cancer patients treated with adjuvant BCG
Zachos, I.; Tzortzis, V.; Mitrakas, L.; Samarinas, M.; Karatzas, A.; Gravas, S.; Vandoros, G. P.; Melekos, M. D.; Papavassiliou, A. G. (2014)We conducted a retrospective study to determine the prognostic significance of age, gender, associated carcinoma in situ, stage, number of tumors, and tumor size for patients with high-risk non-muscle-invasive bladder ...