Parcourir par auteur "Kossida, S."
Voici les éléments 1-5 de 5
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A Comprehensive Phylogenetic Analysis of Deadenylases
Pavlopoulou, A.; Vlachakis, D.; Balatsos, N. A. A.; Kossida, S. (2013)Deadenylases catalyze the shortening of the poly(A) tail at the messenger ribonucleic acid (mRNA) 3'-end in eukaryotes. Therefore, these enzymes influence mRNA decay, and constitute a major emerging group of promising ... -
An Integrated In Silico Approach to Design Specific Inhibitors Targeting Human Poly(A)-Specific Ribonuclease
Vlachakis, D.; Pavlopoulou, A.; Tsiliki, G.; Komiotis, D.; Stathopoulos, C.; Balatsos, N. A. A.; Kossida, S. (2012)Poly(A)-specific ribonuclease (PARN) is an exoribonuclease/deadenylase that degrades 3'-end poly(A) tails in almost all eukaryotic organisms. Much of the biochemical and structural information on PARN comes from the human ... -
A novel mutation of the hGR gene causing Chrousos syndrome
Nicolaides, N. C.; Geer, E. B.; Vlachakis, D.; Roberts, M. L.; Psarra, A. M. G.; Moutsatsou, P.; Sertedaki, A.; Kossida, S.; Charmandari, E. (2015)Background Natural mutations in the human glucocorticoid receptor (hGR, NR3C1) gene cause Chrousos syndrome, a rare condition characterized by generalized, partial, target-tissue insensitivity to glucocorticoids. Objective ... -
Using graph theory to analyze biological networks
Pavlopoulos, G. A.; Secrier, M.; Moschopoulos, C. N.; Soldatos, T. G.; Kossida, S.; Aerts, J.; Schneider, R.; Bagos, P. G. (2011)Understanding complex systems often requires a bottom-up analysis towards a systems biology approach. The need to investigate a system, not only as individual components but as a whole, emerges. This can be done by examining ... -
Which clustering algorithm is better for predicting protein complexes?
Moschopoulos, C. N.; Pavlopoulos, G. A.; Iacucci, E.; Aerts, J.; Likothanassis, S.; Schneider, R.; Kossida, S. (2011)Background: Protein-Protein interactions (PPI) play a key role in determining the outcome of most cellular processes. The correct identification and characterization of protein interactions and the networks, which they ...