Listar por tema "toll like receptor 9"
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Breg Cells Are Numerically Decreased and Functionally Impaired in Patients with Systemic Sclerosis
(2016)Objective Breg cells, a regulatory cell subset that produces interleukin-10 (IL-10), play a significant role in suppressing autoimmune responses and preventing autoimmunity. This study was undertaken to examine the number ... -
Cytochrome c as a potentially clinical useful marker of mitochondrial and cellular damage
(2016)Mitochondria are evolutionary endosymbionts derived from bacteria. Thus, they bear molecules, such as mitochondrial DNA (mtDNA) that contains CpG DNA repeats and N-formyl peptides (FPs), found in bacteria. Upon cell necrosis ... -
Effect of TNF-α inhibitors on transcriptional levels of pro-inflammatory interleukin-33 and Toll-like receptors-2 and -9 in psoriatic plaques
(2015)Tumor necrosis factor (TNF)-α inhibitors are considered to be effective in the treatment of psoriatic plaques, although the precise therapeutic pathway is not clear. Pro-inflammatory molecules, such as Toll-like receptor ... -
Spotlight on tocilizumab and its potential in the treatment of systemic sclerosis
(2016)Systemic sclerosis (SSc) is a multisystem disease characterized by extensive collagen deposition in skin and internal organs, fibrointimal microvasculopathy, and activation of the immune system. T cells and B cells can ... -
Systemic sclerosis: New evidence re-enforces the role of B cells
(2016)Systemic sclerosis (SSc) is characterized by widespread fibrosis, microangiopathy (vasospasms and stenosis), and formation of autoantibodies. T cell activation has been shown to contribute to fibrosis and microvasculopathy ... -
Toll-like receptor 2, 4 and 9 polymorphisms and their association with ICU-acquired infections in Central Greece
(2018)Purpose: To test the potential of four common Toll-like receptor (TLR) polymorphisms to predispose to specific intensive care unit (ICU)-acquired infections and affect outcomes in a Greek ICU. Materials and methods: The ... -
Toll-like receptors and their role in renal pathologies
(2012)Toll-like receptors (TLRs) are the first identified and best studied family of pattern recognition receptors. Expressed in immunocytes, TLRs initiate innate immune responses and concurrently shape the subsequent adaptive ...